Feasibility of microneedles for percutaneous absorption of insulin

Ito, Yoshiaki; Hagiwara, Eiji; Saeki, Atsushi; Sugioka, Nobuyuki; Takada, Kanji

doi:10.1016/j.ejps.2006.05.011

Cited by 199 publications

(111 citation statements)

References 24 publications

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“…taking tablets). However, many drugs such as insulin are severely degraded by digestion processes and as such cannot be administered in an oral formulation (Ito et al, 2006). Drugs administered through TDD avoid gut and first pass liver metabolism, improving drug bioavailability (Xie et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Transdermal drug delivery by coated microneedles: Geometry effects on effective skin thickness and drug permeability

Davidson

Al-Qallaf

Das

2008

Chemical Engineering Research and Design

140

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can potentially allow the transdermal delivery of many medicaments including large macromolecules that typically cannot diffuse through the skin. This paper addresses the use of microneedles coated with a drug solution film. In particular, we identify how the geometries of various microneedles affect the drug permeability in skin. Effective skin permeability is calculated for a range of microneedle shapes and dimensions in order to identify the most 20 efficient geometry. To calculate effective permeability (P eff ), the effective skin thickness (H eff ) is calculated. These are then plotted for insulin as a model drug to see how various microneedle parameters affect the profiles of both H eff and P eff . It is found that the depth of penetration from the microneedle array is the most important factor in determining P eff , followed by the microneedle spacings. Other parameters such as microneedle diameter and 25 coating depth are less significant.

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Section: Introductionmentioning

confidence: 99%

Transdermal drug delivery by coated microneedles: Geometry effects on effective skin thickness and drug permeability

Davidson

Al-Qallaf

Das

2008

Chemical Engineering Research and Design

140

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“…(Henry et al, 1998;Park et al, 2005;Gupta et al, 2009;Swain et al, 2011;Kommareddy et al, 2013;Mansoor et al, 2013;Torrisi et al, 2013;Pierre & Rossetti, 2014). There has been a lot of research conducted on MNs for the delivery and monitoring of various drugs such as glucose control for diabetics (Ito et al, 2006;Nordquist et al, 2007;Ainslie & Desai, 2008;El-Laboudi et al, 2013;Taylor & Sahota, 2013;Ita, 2014), Alzheimer's disease (Wei-Ze et al, 2010), anticancer (Fang et al, 2008) and other conditions (Ezan, 2013). Vaccines have also been a prominent research field with numerous studies developed to allow dose sparing effects (Edens et al, 2013;Norman et al, 2014;van der Maaden et al, 2014).…”

Section: Trends In Mn Dd Methodsmentioning

confidence: 99%

“…There are numerous journal papers that have reviewed different types of DD technologies (Wu et al, 2012;Chandrasekhar et al, 2013;Fazil et al, 2013;Kamboj et al, 2013;Tuan-Mahmood et al, 2013;Ita, 2014;Nalwa, 2014;Wolff, 2014) and specific drug deliveries, such as insulin (Martanto et al, 2004;Zahn et al, 2005;Ito et al, 2006;Khanna et al, 2008;Taylor & Sahota, 2013;Bronger, 2014;Natayan, 2014). A number of review papers have also discussed specific technologies, e.g.…”

Section: Dd Routesmentioning

confidence: 99%

“…The biodegradable MNs were fabricated using a lithographic approach. Dissolving MNs were fabricated by Ito et al (2006) in which insulin was mixed at room temperature to dextrin and deionized water and dried in a desiccator after thread was attached. Three different mixtures of insulin were made and tested on rats, which illustrated the uses of dissolving MNs to successfully deliver the drug precutaneously.…”

Section: Solid Mnsmentioning

confidence: 99%

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Microneedles for drug delivery: trends and progress

2014

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In recent years, there has been a surge in the research and development of microneedles (MNs), a transdermal delivery system that combines the technology of transdermal patches and hypodermic needles. The needles are in the hundreds of micron length range and therefore allow relatively little or no pain. For example, biodegradable MNs have been researched in the literature and have several advantages compared with solid or hollow MNs, as they produce non-sharp waste and can be designed to allow rapid or slow release of drugs. However, they also pose a disadvantage as successful insertion into the stratum corneum layer of the skin relies on sufficient mechanical strength of the biodegradable material. This review looks at the various technologies developed in MN research and shows the rapidly growing numbers of research papers and patent publications since the first invention of MNs (using time series statistical analysis). This provides the research and industry communities a valuable synopsis of the trends and progress being made in this field.

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“…It can alert patients and provide the guidance when the dose of the drug to be delivered should be accurately controlled 47, 48, 49, 50. Currently, several wearable sensors for health monitoring have been explored, including devices that measure hydration,51 strain,52 glycaemia,53, 54, 55 metabolic acid,56 and cardiorespiratory signals 53.…”

mentioning

confidence: 99%

Toward Self‐Powered Wearable Adhesive Skin Patch with Bendable Microneedle Array for Transdermal Drug Delivery

2016

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A wearable adhesive skin patch for transdermal drug delivery is developed with bendable microneedles, dry adhesive and triboelectric energy harvester (TEH). The bendable microneedle array can overcome the needle breakage issue. The dry adhesive can realize a conformal attachment. The TEH can generate power when attached on flat skin or joint to power active components to be integrated in the future.

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Feasibility of microneedles for percutaneous absorption of insulin

Cited by 199 publications

References 24 publications

Transdermal drug delivery by coated microneedles: Geometry effects on effective skin thickness and drug permeability

Transdermal drug delivery by coated microneedles: Geometry effects on effective skin thickness and drug permeability

Microneedles for drug delivery: trends and progress

Toward Self‐Powered Wearable Adhesive Skin Patch with Bendable Microneedle Array for Transdermal Drug Delivery

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