Feasibility of measuring pericoronary fat from precontrast scans: Effect of iodinated contrast on pericoronary fat attenuation

Almeida, Simone Gonçalves de; Pelter, Megan; Shaikh, Kashif; Cherukuri, Lavanya; Birudaraju, Divya; Kim, Kyle; Modi, Jenil; Shekar, Chandana; Sheikh, Mohammad Amin; Kinninger, April; Hill, Elizabeth; Mutchler, Christy; Tabb, Laura; Falk, Robert; Dey, Damini; Gonzalez, Jorge; Karlsberg, Ronald P.; Wesbey, George E.; Budoff, Matthew J.

doi:10.1016/j.jcct.2020.04.004

Cited by 21 publications

(20 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Assessing the impact of factors extraneous to disease pathophysiology on PCAT attenuation has formed the basis of a number of recent studies, which have explicated the role played by the use of contrast on PCAT attenuation. Almeida et al [ 95 ] studied patients with CAD who underwent pre- and post-contrast scans, which were used as points of comparison for attenuation and volume differences owed to the impact of contrast enhancement. Pre-contrast scans had significantly lower PCAT attenuation of approximately 3–4 HU, as well as lower PCAT volume, compared to post-contrast scans.…”

Section: Coronary Computed Tomography Angiography (Cta) Assessment Of Eat and Pericoronary Adipose Tissue (Pcat) As A Marker Of Coronary mentioning

confidence: 99%

The Emerging Role of CT-Based Imaging in Adipose Tissue and Coronary Inflammation

Yuvaraj

Cheng

Lin

et al. 2021

Cells

View full text Add to dashboard Cite

A large body of evidence arising from recent randomized clinical trials demonstrate the association of vascular inflammatory mediators with coronary artery disease (CAD). Vascular inflammation localized in the coronary arteries leads to an increased risk of CAD-related events, and produces unique biological alterations to local cardiac adipose tissue depots. Coronary computed tomography angiography (CTA) provides a means of mapping inflammatory changes to both epicardial adipose tissue (EAT) and pericoronary adipose tissue (PCAT) as independent markers of coronary risk. Radiodensity or attenuation of PCAT on coronary CTA, notably, provides indirect quantification of coronary inflammation and is emerging as a promising non-invasive imaging implement. An increasing number of observational studies have shown robust associations between PCAT attenuation and major coronary events, including acute coronary syndrome, and ‘vulnerable’ atherosclerotic plaque phenotypes that are associated with an increased risk of the said events. This review outlines the biological characteristics of both EAT and PCAT and provides an overview of the current literature on PCAT attenuation as a surrogate marker of coronary inflammation.

show abstract

Section: Coronary Computed Tomography Angiography (Cta) Assessment Of Eat and Pericoronary Adipose Tissue (Pcat) As A Marker Of Coronary mentioning

confidence: 99%

The Emerging Role of CT-Based Imaging in Adipose Tissue and Coronary Inflammation

Yuvaraj

Cheng

Lin

et al. 2021

Cells

View full text Add to dashboard Cite

show abstract

“…To our knowledge, ours is the first study to report such PCAT attenuation measurement and its clinical results. The absolute value of fat attenuation in Hounsfield units might potentially differ between an ideal ECG-triggered and contrast computed tomography angiogram and a non-contrast, non-ECG triggered HRCT as available in the current study, although a good correlation of between PCAT measurement is now documented between precontrast and postcontrast scans (22). However, since all patients underwent the same modality of HRCT scans, the relative comparison between alive and dead patients in our study should be unbiased by this limitation, even more considering there was no difference in the number of patients with an increased heart rate (>100 beats per minute, table 1) which in theory could lead to partial volume effect of coronary artery lumen and its surroundings.…”

Section: Discussionmentioning

confidence: 82%

Lung disease severity, Coronary Artery Calcium, Coronary inflammation and Mortality in Coronavirus Disease 2019

Gaibazzi¹,

Martini²,

Mattioli³

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…Given the high spatial resolution of CT and that adipose tissue has distinct attenuation values, EFV is readily identified allowing for accurate volumetric measurement [6]. Fat attenuation and volume can also be reliably measured from pre-contrast calcium scans, with volume quantification showing particularly strong correlation [26]. It is one of the more reliable and reproducible methods for estimating the extent of epicardial fat volume with high spatial resolution [27].…”

Section: Discussionmentioning

confidence: 99%

Excess epicardial fat volume in post- menopausal women is associated with increased cardiovascular structural and functional abnormalities

Shahawy¹,

Mohan²,

Sabatini³

2021

J Integr Cardiol

View full text Add to dashboard Cite

Epicardial fat volume (EFV) has been associated with an increase in cardiovascular structural and functional abnormalities (CVSFA). The purpose of the study is to assess whether a stepwise excess increase in EFV is associated with a proportional increase in CVSFA. We screened 276 asymptomatic individuals, ages 50 to 89, for cardiovascular disease (CVD) risk using the Rasmussen Risk Score (RRS) and a CT scan for the coronary artery calcium score (CACS) and EFV determination. The RRS scoring system consists of 10 tests; 7 of which are vascular and 3 are cardiac. Additional tests included fasting blood sugar, fasting lipid profile, CRP, Pro-BNP, waist circumference, and BMI. Of the 276 total subjects that were asymptomatic of cardiac symptoms, 144 were post-menopausal women (52.2%). These 144 female subjects were further divided into 5 groups based on their EFV: Group 1 (31 subjects) with an EFV <69 cm 3 , Group 2 (45 subjects) with an EFV between 70 cm 3 and 94 cm 3 , Group 3 (21 subjects) with an EFV between 95 cm 3 and 119 cm 3 , Group 4 (33 subjects) with an EFV between 120 cm 3 and 144 cm 3 , and Group 5 (14 subjects) with an EFV of 145 cm 3 and greater. The statistical analysis used to determine statistical significance of the study results included ANOVA, T-Test and Chi-Square analysis. Based on our data, excess epicardial fat volume is associated with earlier structural and functional abnormalities in comparison to normal epicardial fat volume levels.

show abstract

Feasibility of measuring pericoronary fat from precontrast scans: Effect of iodinated contrast on pericoronary fat attenuation

Cited by 21 publications

References 6 publications

The Emerging Role of CT-Based Imaging in Adipose Tissue and Coronary Inflammation

The Emerging Role of CT-Based Imaging in Adipose Tissue and Coronary Inflammation

Lung disease severity, Coronary Artery Calcium, Coronary inflammation and Mortality in Coronavirus Disease 2019

Excess epicardial fat volume in post- menopausal women is associated with increased cardiovascular structural and functional abnormalities

Contact Info

Product

Resources

About