Feasibility of Left Ventricle Ejection Fraction Calculation Using Electrocardiographically Gated SPECT Acquisition of 99mTc-HDP Bone Scintigraphy in Cardiac Amyloidosis

Abstract

We performed bone scintigraphy in 6 patients with suspected cardiac amyloidosis. To evaluate feasibility of left ventricle function analysis, we additionally performed electrocardiographically gated SPECT acquisition. The cardiac-gated SPECT data confirmed adequate tracer uptake for automatic myocardial contour determination. LVEF estimations ranged between 24% and 54%. Comparison with LVEF estimations from prior echocardiography generally showed only small differences. In one patient, the LVEF measurements from both methods seemed discordant, probably reflecting actual LVEF worsening, which was confirmed at follow-up echocardiography. Therefore, our results may suggest that cardiac-gated SPECT acquisition at bone scintigraphy can provide meaningful estimates of LVEF.

Divergent Findings in the Diagnosis of ATTR-CM Using Common Cardiac Diagnostics and 99mTc-DPD Scintigraphy

“…11,12 Furthermore, a recent study demonstrated that the acquisition of a supplementary ECG-gated SPECT can estimate LVEF and detect focal depositions. 13 Clinical Nuclear Medicine • Volume 48, Number 10, October 2023 99m…”

“…The implementation of an additional SPECT is crucial to distinguish blood pooling from myocardial retention; 3-dimensional image acquisition provides information about tracer distribution within the ventricle 11,12 . Furthermore, a recent study demonstrated that the acquisition of a supplementary ECG-gated SPECT can estimate LVEF and detect focal depositions 13 …”