Feasibility of Left Atrial Appendage Occlusion for Left Atrial Appendage Thrombus in Patients With Persistent Atrial Fibrillation

Stroke Prevention in Atrial Fibrillation: Focus on Asian Patients

“…During the mean 23.2±17.5-month follow-up, 7 major adverse cardiac events occurred (1 cardiovascular death, 6 ischemic strokes). 76) Another multicenter study in Korea (n=96) demonstrated that during 21.9-month follow-up after LAAO, the incidence of death, stroke, and major bleeding was 5.2%, 4.2%, and 1.0%, respectively. 77) On transesophageal echocardiography of 93 patients within 6 months after the procedure, 24 residual leaks were observed (25.8%; 2 mild, 18 moderate, and 4 major).…”

Rationale for cerebral protection in patients with left atrial appendage thrombus during percutaneous left atrial appendage closure: a single-center initial experience

“…Lee et al published the results of the multicenter registry of LAAC procedures, in which they compared the results of the use of Amplatzer or Watchman occluders; in 10 patients undergoing these treatments, they found a clot in the LAA, whereas in 132 patients, no thrombus was found. The study showed no significant differences concerning the safety of the procedures and the effectiveness of protection against stroke in distant observation [4].…”

Left atrial appendage device closure in an adult patient with univentricular heart: First reported case

“…Nevertheless, few reports have demonstrated the safety and feasibility of percutaneous device closure in patients with persistent LAA thrombus despite appropriate anticoagulation therapy or in patients with contraindication to anticoagulation. 11 , 12 If percutaneous LAA closure is considered in cases with known or suspected LAA thrombus, every effort should be made to avoid contrast injection in the LAA. In our case, given the complexity of the underlying congenital heart disease and particularly unusual orientation of the LAA in relation to the common atrium, it was felt that the benefit of minimal contrast injection outweighs the risk of thrombus dislodgment with directing of the tip of the angiographic catheter away from the location of the thrombus and with injection of minimal amount of contrast.…”