Feasibility of large-scale screening using N-ERC/mesothelin levels in the blood for the early diagnosis of malignant mesothelioma

Imashimizu, Kohta; Shiomi, Kazu; Maeda, Manabu; Aoki, Naoko; Igarashi, Kiyoko; Suzuki, Fumio; Koizumi, Mitsuru; Suzuki, Kenji; Hino, Okio

doi:10.3892/etm.2011.225

Cited by 9 publications

(8 citation statements)

References 7 publications

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“…As previously reported (12), we initially defined the participants as high-risk if they exhibited abnormal levels (>8.0 ng/ml) of N-ERC/mesothelin. However, it was considered that this criterion was not sufficient for a screening and that more optimal criteria were required.…”

Section: Methodsmentioning

confidence: 99%

Retrospective analysis of large-scale research screening of construction workers for the early diagnosis of mesothelioma

Hirohashi

Igarashi²,

Abe

et al. 2013

Molecular and Clinical Oncology

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The early diagnosis of mesothelioma, an aggressive malignant tumor, is considered to be important for prognosis. X-ray is commonly used for the assessment of a mass in a population exhibiting a risk factor. However, there are currently no available studies indicating that such an assessment may be used to achieve early diagnosis and improve the patient's outcome. We previously reported that N-ERC/mesothelin may be a useful blood tumor marker for mesothelioma. In order to investigate whether this tumor marker is useful for early diagnosis in a mass examination, in 2007 we initiated a 5-year large-scale screening of construction workers with a risk of asbestos exposure in Japan. Blood samples were collected annually and N-ERC/mesothelin levels were determined. Based on the results of those findings, along with medical history and related data, we screened the participants to identify a high-risk population. As a result, 62 subjects were identified among ~40,000 participants as the high-risk population. Two of these 62 participants subsequently developed mesothelioma, although the remaining participants have not yet developed mesothelioma. In conclusion, N-ERC/mesothelin may be useful as a blood tumor marker in the early diagnosis of mesothelioma in a mass examination. A future prospective study to confirm the findings of this research screening is currently under planning.

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Section: Methodsmentioning

confidence: 99%

Retrospective analysis of large-scale research screening of construction workers for the early diagnosis of mesothelioma

Hirohashi

Igarashi²,

Abe

et al. 2013

Molecular and Clinical Oncology

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“…It has been suggested that mesothelin plays a role in tumor adhesion and metastasis based on evidence that it can bind to MUC16 (also known as CA 125), which is highly glycosylated, to mediate heterotypic cell adhesion (Imashimizu et al 2011).…”

Section: Discussionmentioning

confidence: 99%

Mesothelin as a biomarker for ovarian carcinoma: a meta-analysis

Madeira

Dondossola

Farias

et al. 2016

An. Acad. Bras. Ciênc.

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The objective of this work was to estimate the accuracy of mesothelin as a biomarker for ovarian cancer. A quantitative systematic review was performed. A comprehensive search of the Medline, LILACS, SCOPUS, Embase, Cochrane Central Register of Controlled Trials, Biomed Central, and ISI Web of Science databases was conducted from January 1990 to June 2015. For inclusion in this systematic review, the papers must have measured mesothelin levels in at least two histological diagnoses; ovarian cancer (borderline or ovarian tumor) vs. benign or normal ovarian tissue. For each study, 2 x 2 contingency tables were constructed. We calculated the sensitivity, specificity and diagnostic odds ratio. The verification bias was performed according to QUADAS-2. Statistical analysis was performed with the software Stata 11, Meta-DiSc® and RevMan 5.2. Twelve studies were analyzed, which included 1,561 women. The pooled sensitivity was 0.62 (CI 95% 0.58 -0.66) and specificity was 0.94 (CI 95% 0.92 -0.95). The DOR was 38.92 ). Our systematic review shows that mesothelin cannot serve alone as a biomarker for the detection of ovarian cancer.

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“…The MPM diagnosis was performed in 1 of 80 subjects with a marker value higher than a predefined cut-off [39]. …”

Section: Discussionmentioning

confidence: 99%

Is Soluble Mesothelin-Related Protein an Upfront Predictive Marker of Pleural Mesothelioma? A Prospective Study on Italian Workers Exposed to Asbestos

et al. 2013

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Objective: Soluble mesothelin-related peptide (SMRP) may be useful in the diagnosis and detection of early stage mesothelioma. We investigated the SMRP upfront predictive role for mesothelioma in asbestos-exposed workers. Methods: A total of 1,715 subjects underwent a first visit and were invited for a follow-up after 1 and 2 years, with a clinical examination and blood sampling. SMRP was measured by an ELISA assay. Results: Median SMRP at the first visit was 0.45 [interquartile range (IQR) i.e. 25th-75th percentile: 0.30-0.67 nmol/l]. In all, 1,676 subjects (97.8%) were followed up for a median period of 47.1 months. SMRP was measured at the first visit and at both follow-up visits in 1,536 subjects. At follow-up, 3 subjects were diagnosed with an epithelioid mesothelioma. In these cases, SMRP at the first visit ranged from 0.17 to 0.52 nmol/l. Malignant pleural mesothelioma was diagnosed 9-17 months after the last SMRP evaluation. No SMRP variation was observed during the follow-up. Other 61 miscellaneous cancers were diagnosed (median SMRP at first visit: 0.50 nmol/l, IQR: 0.34-0.71 nmol/l). Conclusions: Our results did not support the usefulness of SMRP as an early marker for the detection of the disease for a time interval of 1 year.

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Feasibility of large-scale screening using N-ERC/mesothelin levels in the blood for the early diagnosis of malignant mesothelioma

Cited by 9 publications

References 7 publications

Retrospective analysis of large-scale research screening of construction workers for the early diagnosis of mesothelioma

Retrospective analysis of large-scale research screening of construction workers for the early diagnosis of mesothelioma

Mesothelin as a biomarker for ovarian carcinoma: a meta-analysis

Is Soluble Mesothelin-Related Protein an Upfront Predictive Marker of Pleural Mesothelioma? A Prospective Study on Italian Workers Exposed to Asbestos

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