Feasibility of home-based exercise training in men with metastatic castration-resistant prostate cancer

Hanson, Erik D.; Alzer, Mohamdod; Carver, Jackson; Stopforth, Cameron K.; Lucas, Alexander R.; Whang, Young E.; Milowsky, Matthew I.; Bartlett, David B.; Harrison, Michael R.; Bitting, Rhonda L.; Deal, Allison M.; Stoner, Lee; Hackney, Anthony C.; Battaglini, Cláudio L.

doi:10.1038/s41391-022-00523-8

Cited by 8 publications

(4 citation statements)

References 51 publications

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“…The current study shows that benefits can be achieved through a clinical intervention carried out in non-clinical environment in a completely safe and supervised manner, conducted through online meetings with patients and with the initial recommendation of the oncologist (Hardcastle and Cohen, 2018). In contrast with other oncological home-based interventions were participants make the recommended exercise on their own or this periodic supervision strategies (Hanson et al, 2023;Pelosi et al, 2023), the current exercise program was completely supervised in real time. For this purpose, both the participants and the trainer had their phone or computer cameras switched on and participants' heart rate was monitored and controlled in real time by the trainer.…”

Section: Discussionmentioning

confidence: 88%

An online home-based exercise program improves autonomic dysfunction in breast cancer survivors

Lavín-Pérez,

Collado-Mateo,

Hinojo González

et al. 2023

Front. Physiol.

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Introduction: Exercise interventions for breast cancer survivors have proved their potential to improve clinical, physical, and psychosocial outcomes. However, limited studies have explored exercise effects on autonomic dysfunction and the measurement of exercise tolerance and progression through daily heart rate variability (HRV).Purpose: To analyze the effects of a 16-wk exercise intervention on the autonomic modulation of breast cancer survivors, as well as to examine the evolution of daily measured HRV and its interaction with exercise sessions in this population.Methods: A total of 29 patients who had undergone chemotherapy and radiotherapy were randomly assigned to the exercise group or to the control group. The exercise intervention was delivered remotely through online meetings and consisted of supervised training resistance and cardiovascular exercise 3 times per week. During the intervention all patients measured their HRV daily obtaining the napierian logarithm of the root mean square of successive differences between normal heartbeats (lnrMSSD) and the napierian logarithm of the standard deviation of the interbeat interval of normal sinus beats (lnSDNN) values at four moments: day 0 (the morning of the training sessions), 24, 48, and 72 h after exercise.Results: The results revealed a significant interaction between group and months during the intervention period for lnrMSSD and lnSDNN (p < 0.001). Additionally, there were significant differences in lnSDNN recovery time between months (p < 0.05), while differences in lnrMSSD become apparent only 24 h after exercise (p = 0.019). The control group experienced a significant decrease in both variables monthly (p < 0.05) while exercise group experienced a significant increment (p < 0.05).Conclusion: HRV is daily affected by exercise training sessions in cancer patients. Although results strongly support the role of exercise as a post-chemotherapy and radiotherapy rehabilitation strategy for breast cancer survivors to improve autonomic imbalance, further research is necessary to validate these initial findings.

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Section: Discussionmentioning

confidence: 88%

An online home-based exercise program improves autonomic dysfunction in breast cancer survivors

Lavín-Pérez,

Collado-Mateo,

Hinojo González

et al. 2023

Front. Physiol.

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“…In this sense, a 12-week home-based program, including walking and resistance training with elastic bands, in men with metastatic prostate cancer showed a 47% of recruitment rate, 27% of patients who withdrew, and 80% of adherence to the walking program, and only 63% of resistance component. 9 Similarly, another trial testing the feasibility of a walking program in patients with different metastatic cancer reported a 38% of recruitment rate and a 45% of attrition rate. 36 Our study reported high rates of recruitment, adherence and attendance, and a low dropout; additionally, no important difference for such feasibility outcomes was observed between the personal training program and the home-based program and neither the aerobic and resistance components.…”

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, most available evidence derives from early-stage settings, whereas minor attention has been dedicated to the metastatic context. Few investigations have been conducted on patients affected by a metastatic disease 6-14 ; most of them tested combined aerobic and resistance training delivered through a supervision-based approach 7 , 8 , 10 , 12 , 14 or with a home-based program, 6 , 9 , 11 whereas just one explored the impact of aerobic training. 13 Preliminary evidence deriving from these researches reported mixed findings regarding benefits in physical fitness and quality of life, which are the most studied outcomes.…”

Section: Introductionmentioning

confidence: 99%

A Feasibility Study Investigating an Exercise Program in Metastatic Cancer Based on the Patient-Preferred Delivery Mode

Avancini,

Borsati,

Baldo

et al. 2024

The Oncologist

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Background Feasibility of exercise in patients with metastatic cancer is still a challenge. This study aimed to determine the feasibility and preliminary efficacy of an exercise intervention based on a patient-preferred delivery mode in patients affected by metastatic cancer. Materials and Methods Forty-four patients with a confirmed diagnosis of metastatic cancer were recruited in a 3-month exercise program. Whereas the exercise program consisted of aerobic and resistance activities performed twice a week, the participants may choose the mode of delivery: home based, personal training, or group based. The primary endpoint was the feasibility, defined by recruitment rate, attendance, adherence, dropout rate, tolerability (comparing the session RPE with the target RPE), and safety (using the Common Terminology Criteria for Adverse Events, version 5.0). Secondary endpoints included cardiorespiratory fitness (six minutes walking test), muscle strength (handgrip strength test and isometric leg press test), flexibility (the back scratch and chair sit and reach tests), anthropometric parameters (body mass index and waist-hip ratio), quality of life (EORTC QLQ C-30 questionnaire), and amount of physical exercise (Godin’s Shepard Leisure Time Exercise Questionnaire). Descriptive statistics, Student t test, and Wilcoxon signed rank test were used to analyze data. Results The study recruitment rate was 81%. Out of 44 recruited patients, 28 chose the personal training program, 16 chose the home-based program, and none chose the group-based program. Nine dropouts occurred (20%), 6 in the personal training program, and 3 in the home-based intervention. The median attendance rate was 92%, adherence was 88%, tolerability was 100%, and 9 nonsevere adverse events were registered during the exercise sessions. An increase in cardiorespiratory fitness (P < .001) and flexibility (P = .011 for chair sit and reach; P = .040 for back scratch) was observed at the end of the intervention, while no changes in anthropometric values and muscle strength were detected. Different quality-of-life domains were improved following the intervention, including physical (P = .002), emotional (P < .001), and role functioning (P = .018), fatigue (P = .030), and appetite loss (P = .005). Conclusion A 3-month exercise program based on a patient-preferred delivery mode is feasible in patients with metastatic cancer and may improve physical function and quality of life. Trial Registration NCT04226508

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“…5. "Feasibility of home-based exercise training in men with metastatic castration-resistant prostate cancer" [6]. In a single-arm, multi-site pilot study, a home-based exercise intervention for 12 weeks in men with mCRPC receiving androgen receptor signaling inhibitors resulted in greater endurance, muscle mass, and improved aerobic capacity.…”

mentioning

confidence: 99%

Working hard or hardly working? A brief commentary of latest research on exercise and prostate cancer

Galván

Das

Daniels

et al. 2023

Prostate Cancer Prostatic Dis

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Feasibility of home-based exercise training in men with metastatic castration-resistant prostate cancer

Cited by 8 publications

References 51 publications

An online home-based exercise program improves autonomic dysfunction in breast cancer survivors

An online home-based exercise program improves autonomic dysfunction in breast cancer survivors

A Feasibility Study Investigating an Exercise Program in Metastatic Cancer Based on the Patient-Preferred Delivery Mode

Working hard or hardly working? A brief commentary of latest research on exercise and prostate cancer

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