Feasibility of home-based cardiac rehabilitation in frail older patients: a clinical perspective

Terbraak, Michel; Verweij, Lotte; Jepma, Patricia; Buurman, Bianca M.; Jørstad, Harald T; Reimer, Wilma Jm Scholte Op; Schaaf, Marike van der

doi:10.1080/09593985.2022.2025549

Cited by 3 publications

(1 citation statement)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To overcome this issue, other CR formats have been proposed and are currently being examined (Jin et al, 2014;Abell et al, 2016;Pio et al, 2019;Abreu et al, 2020;Purcell et al, 2020;Forman et al, 2022). Home-based CR programs may improve both participation and outcomes, especially for patients who are living far from standard supervised programs (Besnier et al, 2021;Vonk et al, 2021;Terbraak et al, 2022). With these aspects in mind, the possibility to potentiate CR by L-arginine treatment appears extremely interesting.…”

Section: Discussionmentioning

confidence: 99%

L-Arginine Enhances the Effects of Cardiac Rehabilitation on Physical Performance: New Insights for Managing Cardiovascular Patients During the COVID-19 Pandemic

Mone

Izzo

Marazzi

et al. 2022

J Pharmacol Exp Ther

View full text Add to dashboard Cite

Cardiac rehabilitation (CR) following acute myocardial infarction (AMI) improves physical capacities and decreases hospitalizations and cardiovascular mortality. L-Arginine is the substrate used by nitric oxide (NO) synthase (NOS) to generate NO and it has been shown to exert its beneficial effects on endothelium driving vasodilatation, reducing inflammation, and ameliorating physical function. We hypothesized that L-Arginine could enhance physical capacities in patients who underwent CR after AMI. We designed a study aimed to assess the effects of L-arginine administration on the physical capacity of patients who underwent coronary revascularization after AMI. The trial was carried out amid the COVID-19 pandemic. Patients were assigned, with a 2:1 ratio, to add to their standard therapy 1 bottle containing 1.66 g of L-arginine or 1 bottle of identical aspect apart from not containing L-arginine, twice a day orally for 3 weeks. Patients performed a 6minute walking test (6MWT) and were assessed their Borg modified 0-10 rating of perceived exertion (BRPE) before starting and at the end of the treatment. Seventy-five patients receiving L-Arginine, and thirty-five receiving placebo successfully completed the study. The 6MWT distance increased significantly in the L-Arginine group compared to both baseline and placebo (p<0.0001).Additionally, we observed a significant improvement in the BRPE in patients treated with Larginine but not in the placebo group. Taken together, our data indicate that L-arginine potentiates the response to CR, independently of age, sex, baseline functional capacity, and comorbid conditions.

show abstract