Feasibility of functional MRI at ultralow magnetic field via changes in cerebral blood volume

Buckenmaier, Kai; Pedersen, Anne Juul; SanGiorgio, Paul; Scheffler, Klaus; Clarke, John; Inglis, Ben

doi:10.1016/j.neuroimage.2018.10.071

Cited by 9 publications

(3 citation statements)

References 46 publications

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“…As noted above, the ability to acquire MRI scans in these field-based locations will re quire sacrificing image resolution. Thus, acquiring functional images from lower-field MRI scanners is likely to prove much more difficult than acquiring structural images, because of low signal-to-noise ratio and high field inhomogeneity for traditional gradient echo fMRI (see Buckenmaier et al, 2019 for technical discussion of fMRI with ultra-low field MRI). Finally, Fig.…”

Section: Identifying and Addressing Elsi Issues: Project Methods And Survey Resultsmentioning

confidence: 99%

Emerging ethical issues raised by highly portable MRI research in remote and resource-limited international settings

et al. 2021

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Smaller, more affordable, and more portable MRI brain scanners offer exciting opportunities to address unmet research needs and long-standing health inequities in remote and resource-limited international settings. Field-based neuroimaging research in low- and middle-income countries (LMICs) can improve local capacity to conduct both structural and functional neuroscience studies, expand knowledge of brain injury and neuropsychiatric and neurodevelopmental disorders, and ultimately improve the timeliness and quality of clinical diagnosis and treatment around the globe. Facilitating MRI research in remote settings can also diversify reference databases in neuroscience, improve understanding of brain development and degeneration across the lifespan in diverse populations, and help to create reliable measurements of infant and child development. These deeper understandings can lead to new strategies for collaborating with communities to mitigate and hopefully overcome challenges that negatively impact brain development and quality of life. Despite the potential importance of research using highly portable MRI in remote and resource-limited settings, there is little analysis of the attendant ethical, legal, and social issues (ELSI). To begin addressing this gap, this paper presents findings from the first phase of an envisioned multi-staged and iterative approach for creating ethical and legal guidance in a complex global landscape. Section 1 provides a brief introduction to the emerging technology for field-based MRI research. Section 2 presents our methodology for generating plausible use cases for MRI research in remote and resource-limited settings and identifying associated ELSI issues. Section 3 analyzes core ELSI issues in designing and conducting field-based MRI research in remote, resource-limited settings and offers recommendations. We argue that a guiding principle for field-based MRI research in these contexts should be including local communities and research participants throughout the research process in order to create sustained local value. Section 4 presents a recommended path for the next phase of work that could further adapt these use cases, address ethical and legal issues, and co-develop guidance in partnership with local communities.

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Section: Identifying and Addressing Elsi Issues: Project Methods And Survey Resultsmentioning

confidence: 99%

Emerging ethical issues raised by highly portable MRI research in remote and resource-limited international settings

et al. 2021

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“…Magneto-hydrodynamics (MHD) is very important in medical science as it helps to treat hyperthermia, cancerous tumor or magnetic wounds bleeding reduction during surgeries [7,8]. As blood shows the characteristics of bio magnetic fluids, MHD laws are used to study the flow of blood through under the influence of magnetic field.…”

Section: Introductionmentioning

confidence: 99%

Mathematical Modeling of LDL-C and Blood Flow through an Inclined Channel with Heat in the Presence of Magnetic Field

Kubugha

Amos

2022

Trends Sci

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This investigation revealed that LDL-C and blood flow through an inclined channel with heat in the presence of magnetic field. In this study,mathematical models were formulated for LDL-C and blood flow and energy transfer as a coupled system of partial differential equations (PDEs), the PDEs were scaled using the dimensionless quantities to dimensionless partial differential equations, they are further reduced to an ordinary differential equations (ODEs) using the perturbation method involving the oscillatory term, the governing equations are solved directly using the method of undetermined coefficient. The velocity and temperature functions are obtained with some governing parameters involved, and simulation codes were developed using Mathematica to study the effect of entering parameters on the profiles, and are found to be effective in controlling the flow profiles. It is observed that the governing parameters influenced the flow profiles; also the angle of inclination also influences the flow profile. HIGHLIGHTS Heart attack occurs when blood flow decreases or blood stopped from entering the heart, thereby causing damage to the heart muscle Atherosclerosis is an inflammatory disease resulting in the pathological alteration of the intima and media of arteries such as e.g. the aorta Use mathematical models to investigate the pulsating flow of blood in an atherosclerotic artery in an inclined fashion Carrying out numerical simulation using Mathematica to investigate the impact of the model parameters on the velocity and temperature distribution of the blood. The analysis is relevant in the sense that it helps determine how best clinicians can administer treatment and care GRAPHICAL ABSTRACT

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“…Magneto-hydrodynamics (MHD) is vital in clinical science as it assists with treating hyperthermia, harmful cancer or magnetic injuries draining decrease during medical procedures [7], [8] As blood shows the qualities of bio magnetic fluids, MHD laws are utilized to consider the progression of blood through affected by magnetic field. Blood contains hemoglobin; Hemoglobin is an iron (Fe) containing protein that transports oxygen around the body from the lungs to where it is required, similar to the cerebrum or muscles and so on During the 1930s, it was discovered that hemoglobin has magnetic properties that are diverse relying upon if it is conveying oxygen.…”

Section: Introductionmentioning

confidence: 99%

Oscillatory Flow of LDL-C and Blood Fluid through a Slanted Channel with Heat within the Sight of Magnetic Field

Bunonyo

Eli

2021

EJPHYSICS

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In this research, we investigated LDL-C and blood movement through a slanted channel with heat within the sight of magnetic field. In the evaluation, mathematical models for the LDL-C and blood stream and energy transfer were developed as partially coupled arrangement of partial differential equation (PDEs), the PDEs were scaled utilizing the dimensionless variables to dimensionless ordinary differential equation, they are further reduced to perturbed differential equations (ODEs) utilizing the perturbation parameters including the oscillatory term, where the non-homogenous equation and conditions are solved straightforwardly utilizing the technique for undetermined coefficient. The velocity and temperature profiles are gotten for certain overseeing boundaries included, and Mathematica codes were created utilizing simulate the impact of entering parameters on the profile. It is seen that the overseeing boundaries impacted that the entering pertinent parameters influences blood flow and it helps it controlling the LDL-C concentration, aiding treatment of atherosclerosis.

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Feasibility of functional MRI at ultralow magnetic field via changes in cerebral blood volume

Cited by 9 publications

References 46 publications

Emerging ethical issues raised by highly portable MRI research in remote and resource-limited international settings

Emerging ethical issues raised by highly portable MRI research in remote and resource-limited international settings

Mathematical Modeling of LDL-C and Blood Flow through an Inclined Channel with Heat in the Presence of Magnetic Field

Oscillatory Flow of LDL-C and Blood Fluid through a Slanted Channel with Heat within the Sight of Magnetic Field

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