Feasibility of Extracorporeal Shock Wave Myocardial Revascularization Therapy for Post-Acute Myocardial Infarction Patients and Refractory Angina Pectoris Patients

Abstract

Extracorporeal shockwave myocardial revascularization (ESMR) is one of the new treatment options for refractory angina pectoris (RAP), and some studies have indicated its effectiveness. A single-arm prospective trial to assess the feasibility of ESMR using Cardiospec for patients with post-acute myocardial infarction (AMI) and RAP was designed and performed. The patients were treated with 9 sessions of ESMR to the ischemic areas for 9 weeks. The feasibility measures included echocardiography; cardiac magnetic resonance imaging; troponin T, creatine kinase-MB (CK-MB), and brain natriuretic peptide testing; and a Seattle Angina Questionnaire (SAQ) survey. Three post-AMI patients and 3 RAP patients were enrolled. The post-AMI patients had already undergone revascularization with percutaneous coronary intervention (PCI) in the acute phase. In two patients, adverse events requiring admission occurred: one a lumbar disc hernia in a post-AMI patient and the other congestive heart failure resulting in death in an RAP patient. No apparent elevations in CK-MB and troponin T levels during the trial were observed. Echocardiography revealed no remarkable changes of ejection fraction; however, septal E/E' tended to decrease after treatments (11.6 ± 4.8 versus 9.2 ± 2.8, P = 0.08). Concerning the available SAQ scores for two RAP patients, one patient reported improvements in angina frequency and treatment satisfaction and the other reported improvements in physical limitations and angina stability. In this feasibility study, ESMR seems to be a safe treatment for both post-AMI patients and RAP patients. The efficacy of ESMR for post-AMI patients remains to be evaluated with additional studies.

miRNA‑145 inhibits myocardial infarction‑induced apoptosis through autophagy via Akt3/mTOR signaling pathway in�vitro and in�vivo

“…Early thrombolytic therapy or percutaneous coronary intervention has been adopted to recover blood perfusion in the ischemic site. This method effectively rescues the injured myocardium ( 1 ) and improves myocardial ischemia and necrosis ( 2 ). However, adverse effects include partial myocardial cell apoptosis and loss of heart function.…”

“…In particular, acute myocardial infarction (AMI) is a factor that primarily results in increasing morbidity of CVD patients ( 1 ). Therefore, early, timely and accurate diagnosis and evaluation of AMI are essential for actively administrating effective treatment ( 2 ). Furthermore, early diagnosis may result in timely cardiac reperfusion and reduce mortality ( 2 ).…”

“…Therefore, early, timely and accurate diagnosis and evaluation of AMI are essential for actively administrating effective treatment ( 2 ). Furthermore, early diagnosis may result in timely cardiac reperfusion and reduce mortality ( 2 ). The early treatment of AMI is crucial in the favorable prognosis of patients.…”

The effects of microenergy acoustic pulses on animal model of obesity‐associated stress urinary incontinence. Part 2: In situ activation of pelvic floor and urethral striated muscle progenitor cells

“…9 Research works demonstrated that activation of Wnt/β-catenin signaling enhances myogenesis, 10 increases myoblast proliferation, and enhances muscle growth, 11,12 whereas, it has been reported that Wnt/β-catenin signaling can be activated by mechanotransduction. 13,14 Low-intensity extracorporeal shockwave therapy (Li-ESWT) is one example of a mechanical force that has been employed for many years to treat musculoskeletal disorders, 15 ischemic heart disease, 16,17 and vasculogenic ED. 18,19 We previously reported that Li-ESWT activated penile stem cells 20,21 and very recently, we have applied Li-ESWT effectively to improve SUI.…”

Medically Treated Ventricular Septal Perforation Caused by Takotsubo Cardiomyopathy

“…12) Moreover, the impaired left ventricular systolic function would not fully recover even after surgical or catheter interventions. 13,14) On the other hand, the impaired left ventricular systolic function in Takotsubo cardiomyopathy would fully recover without surgical or catheter interventions in a few weeks. 1) In fact, the cardiac scintigraphy results clearly revealed recovery of the left ventricular systolic function in the present case.…”