Feasibility of Ethyl Glucuronide Nail Testing Biomarker for Alcohol Use Among Youth Living With HIV

Budhwani, Henna; Dinaj, Veronica; Jacques‐Tiura, Angela J.; Pennar, Amy L.; Naar, Sylvie

doi:10.1016/j.jadohealth.2020.12.134

Cited by 3 publications

(3 citation statements)

References 6 publications

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“…The main advantages of this sample material are that compounds with a relatively short lifetime in blood, but with a strong correlation to alcohol consumption, can be entrapped in the hair and are detectable for a longer time (also for years depending on the length of the hair) and at a relatively high concentration [ 64 , 65 ]. In particular, EtG and ethyl sulfate (EtS) are two non-oxidative ethanol metabolites ( Figure 1 ) secreted by the liver which are mainly used as markers of alcohol intake related to incidents [ 66 , 67 , 68 , 69 , 70 , 71 ]. These two markers for recent alcohol intake can be detected in the blood for approximately 10 h after a small to moderate alcohol intake and up to 5 days after large and repeated alcohol intakes [ 67 , 68 , 69 ].…”

Section: Head and Neck Cancer And Alcoholmentioning

confidence: 99%

“…In particular, EtG and ethyl sulfate (EtS) are two non-oxidative ethanol metabolites ( Figure 1 ) secreted by the liver which are mainly used as markers of alcohol intake related to incidents [ 66 , 67 , 68 , 69 , 70 , 71 ]. These two markers for recent alcohol intake can be detected in the blood for approximately 10 h after a small to moderate alcohol intake and up to 5 days after large and repeated alcohol intakes [ 67 , 68 , 69 ]. As the efficacy of these two tests has been demonstrated in multiple settings, it has been also suggested that EtG and EtS should be included in screening tests for injured or at-risk for alcohol abuse people (including pregnant women) to investigate the possible association between residual alcohol effects and injuries, and to verify alcohol abstinence in cases of substance-related disorders [ 72 , 73 ].…”

Section: Head and Neck Cancer And Alcoholmentioning

confidence: 99%

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Alcohol and Head and Neck Cancer: Updates on the Role of Oxidative Stress, Genetic, Epigenetics, Oral Microbiota, Antioxidants, and Alkylating Agents

et al. 2022

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Head and neck cancer (HNC) concerns more than 890,000 patients worldwide annually and is associated with the advanced stage at presentation and heavy outcomes. Alcohol drinking, together with tobacco smoking, and human papillomavirus infection are the main recognized risk factors. The tumorigenesis of HNC represents an intricate sequential process that implicates a gradual acquisition of genetic and epigenetics alterations targeting crucial pathways regulating cell growth, motility, and stromal interactions. Tumor microenvironment and growth factors also play a major role in HNC. Alcohol toxicity is caused both directly by ethanol and indirectly by its metabolic products, with the involvement of the oral microbiota and oxidative stress; alcohol might enhance the exposure of epithelial cells to carcinogens, causing epigenetic modifications, DNA damage, and inaccurate DNA repair with the formation of DNA adducts. Long-term markers of alcohol consumption, especially those detected in the hair, may provide crucial information on the real alcohol drinking of HNC patients. Strategies for prevention could include food supplements as polyphenols, and alkylating drugs as therapy that play a key role in HNC management. Indeed, polyphenols throughout their antioxidant and anti-inflammatory actions may counteract or limit the toxic effect of alcohol whereas alkylating agents inhibiting cancer cells’ growth could reduce the carcinogenic damage induced by alcohol. Despite the established association between alcohol and HNC, a concerning pattern of alcohol consumption in survivors of HNC has been shown. It is of primary importance to increase the awareness of cancer risks associated with alcohol consumption, both in oncologic patients and the general population, to provide advice for reducing HNC prevalence and complications.

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Section: Head and Neck Cancer And Alcoholmentioning

confidence: 99%

Section: Head and Neck Cancer And Alcoholmentioning

confidence: 99%

Alcohol and Head and Neck Cancer: Updates on the Role of Oxidative Stress, Genetic, Epigenetics, Oral Microbiota, Antioxidants, and Alkylating Agents

et al. 2022

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“…We identified only one study in the HIV literature that utilized nail samples to assess a biomarker of a health behavior (i.e., alcohol use; Budhwani et al, 2021); however, the broader literature with HIV‐uninfected participants has used nail samples to test for substance use (Cappelle et al, 2015; Fosen et al, 2017), trace element exposure (Salcedo‐Bellido et al, 2021), and, most commonly, stress (Fischer et al, 2020). Stress has been shown to be related to more rapid disease progression among PWH (Kołodziej, 2016; Leserman, 2008), underscoring the importance of its measurement in HIV‐related research.…”

Section: Introductionmentioning

confidence: 99%

Feasibility of remote self‐collection of dried blood spots, hair, and nails among people with HIV with hazardous alcohol use

Firkey

Tully

Bucci

et al. 2023

Alcohol: Clinical and Experimental Research

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Background The use of biomarkers in behavioral HIV research can help to address limitations of self‐reported data. The COVID‐19 pandemic forced many researchers to transition from standard in‐person data collection to remote data collection. We present data on the feasibility of remote self‐collection of dried blood spots (DBS), hair, and nails for the objective assessment of alcohol use, antiretroviral therapy adherence, and stress in a sample of people with HIV (PWH) who are hazardous drinkers. Methods Standardized operating procedures for remote self‐collection of DBS, hair, and nails were developed for an ongoing pilot study of a transdiagnostic alcohol intervention for PWH. Prior to each study appointment, participants were mailed a kit containing materials for self‐collection, instructions, a video link demonstrating the collection process, and a prepaid envelope for returning samples. Results A total of 133 remote study visits were completed. For DBS and nail collection at baseline, 87.5% and 83.3% of samples, respectively, were received by the research laboratory, of which 100% of samples were processed. Although hair samples were intended to be analyzed, most of the samples (77.7%) were insufficient or the scalp end of the hair was not marked. We, therefore, decided that hair collection was not feasible in the framework of this study. Conclusion An increase in remote self‐collection of biospecimens may significantly advance the field of HIV‐related research, permitting the collection of specimens without resource‐intensive laboratory personnel and facilities. Further research is needed on the factors that impeded participants' ability to complete remote biospecimen collection.

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Assessment of substance exposures in nail clipping samples: A systematic review

Bandoli,

Anunziata,

Bogdan

et al. 2024

Drug and Alcohol Dependence

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Feasibility of Ethyl Glucuronide Nail Testing Biomarker for Alcohol Use Among Youth Living With HIV

Cited by 3 publications

References 6 publications

Alcohol and Head and Neck Cancer: Updates on the Role of Oxidative Stress, Genetic, Epigenetics, Oral Microbiota, Antioxidants, and Alkylating Agents

Alcohol and Head and Neck Cancer: Updates on the Role of Oxidative Stress, Genetic, Epigenetics, Oral Microbiota, Antioxidants, and Alkylating Agents

Feasibility of remote self‐collection of dried blood spots, hair, and nails among people with HIV with hazardous alcohol use

Assessment of substance exposures in nail clipping samples: A systematic review

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