Feasibility of Echocardiographic Techniques to Detect Subclinical Cancer Therapeutics–Related Cardiac Dysfunction among High-Dose Patients When Compared with Cardiac Magnetic Resonance Imaging

Speckle tracking echocardiography predicts early subclinical anthracycline cardiotoxicity in patients with breast cancer

“…Previous studies also showed that GLS is the optimal marker providing incremental information to that provided by other methods. Toro‐Salazar et al reported recently on cardiotoxicity and the feasibility of echocardiographic techniques compared with cardiac MRI and showed that three‐dimensional echocardiographic EF < 55%, end‐systolic volume index > 29 mL/m 2 , 3‐dimensional speckle‐tracking echocardiographic peak GLS magnitude < −17.5%, and a decrease in early atrial myocardial velocity at the interventricular septum of <10 cm/s by Doppler tissue imaging are the most sensitive transthoracic echocardiographic parameters to identify subjects with subclinical myocardial dysfunction by cardiac magnetic resonance (CMR). The results of our study show that a significant decrease in LV GLS and GCS occurred after chemotherapy (Table ).…”

“…LVEF in the range of 53% to 73% should be classified as normal . For the present study, we defined cardiotoxicity as a drop in LVEF to ≤53% or an absolute decrease of ≥10% on a follow‐up echocardiogram (event group), which may be the cause of the lower cutoff value compared with other reports …”

“…Two‐dimensional speckle tracking echocardiography (2D‐STE) is a promising technique that can evaluate cardiac mechanics in the three domains of contractility and can be used to quantify regional and global systolic and diastolic function with greater accuracy than the conventional measures of ejection fraction (EF) . A growing body of literature supports the use of myocardial deformation parameters to detect early myocardial injury and to forecast ventricular dysfunction in patients receiving cancer therapy . However, there are very few data on the right ventricular (RV) mechanics in this population.…”

Comprehensive review on cardio-oncology: Role of multimodality imaging

“…53 In anthracycline-treated pediatric cancer survivors, 3DE had the highest sensitivity in the detection of subclinical myocardial dysfunction (EF \55%) identified by CMRi. 54 Compared to 2DE, noncontrast 3DE exhibited lower temporal variability in sequential EF assessments, with better intra-and inter-observer, as well as test-retest variability, in an analysis of 56 patients with breast cancer followed with sequential echocardiograms at baseline, then every 3 months for 1 year. EF assessment varied up to 10-13% by 2DE approach versus 5-6% with noncontrast 3DE techniques (with no improvement in EF variability with contrast administration).…”

Speckle-Tracking Echocardiography Improves Pre-operative Risk Stratification Before the Total Cavopulmonary Connection

“…9, 10 It has been shown to be more sensitive in detecting changes in ventricular function in children and adults with heart disease than more conventional measures, such as ejection fraction. 11-13 However, no studies investigating the clinical usefulness of STE in predicting post-TCPC outcomes in single ventricle patients have been performed. The aims of this study were to: 1) investigate the association between pre-operative measures of myocardial deformation and post-operative length of stay (LOS) after TCPC and 2) determine if these STE measures of ventricular function improve risk stratification prior to TCPC over conventional risk factors obtained during invasive cardiac catheterization.…”