Feasibility of dual‐task gait to estimate Alzheimer's related cognitive decline in Down syndrome

Pelt, Kathryn L. Van; Koehl, Lisa; Caban‐Holt, Allison; Anderson-Mooney, Amelia J.; Head, Elizabeth; Schmitt, Frederick A.

doi:10.1002/dad2.12092

Cited by 3 publications

(23 citation statements)

References 43 publications

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“…There is a need to explore functional measures such as fall risk, fall incidents, and functional mobility to gain a better understanding of the role they play in the progression of AD in DS 1,8,9 . Falls and functional mobility are associated with clinical measures of cognition and are a non‐cognitive behavioral biomarker of preclinical AD and AD 9,16,18,29 . A better understanding of falls and functional mobility could inform the non‐cognitive biomarker profile in adults with DS through a direct and less‐invasive method of assessment, thus reducing the burden for both the participant and caregivers 5,9,51 …”

Section: Discussionmentioning

confidence: 99%

“…27,34 Ptomey et al 37 and Van Pelt et al 29 used exploratory methods to ascertain the level of exercise needed to affect cognition and/or influence ADRD pathology. 28,29,37 Ptomey et al 37 investigated the optimal dosage of physical activity through the use of a Fitbit over the course of 12 weekly virtual group-exercise sessions. This study noted that individuals who attended two group sessions per week improved their visual memory and new learning performance tasks post intervention.…”

Section: Physical Activity and Motor Coordinationmentioning

confidence: 99%

“…For example, falls and functional mobility are associated with clinical measures of cognition and may be a non-cognitive behavioral marker of AD. [14][15][16][17][18] A fall is an unexpected event in which a person comes to rest on the ground, floor, or a lower level. 9 Although individuals with DS have a higher rate of falls, it remains unknown when falls occur in the progression of AD in adults with DS.…”

Section: Ds the Estimated Number Of Individuals With Ds Living In The...mentioning

confidence: 99%

“…Fleming et al 34 with possible long-term benefits. 27,34 Ptomey et al 37 and Van Pelt et al 29 used exploratory methods to ascertain the level of exercise needed to affect cognition and/or influence ADRD pathology. 28,29,37 Ptomey et al 37 investigated the optimal dosage of physical activity through the use of a Fitbit over the course of 12 weekly virtual group-exercise sessions.…”

Section: Physical Activity and Motor Coordinationmentioning

confidence: 99%

“…Research Question 2: What is the current evidence investigating the risk of falling and falls among adults aging with DS and ADRD? Van Pelt et al 29 was the only study to our knowledge that investigated dualtask gait and functional mobility in aging adults with DS. Our study team did not find any additional studies within the search period that addressed fall risk and/or falls incidents.…”

Section: Current Evidence Of the Risk Of Falling And Fallsmentioning

confidence: 99%

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Down syndrome and Alzheimer's disease: A scoping review of functional performance and fall risk

Washington

Cler

Lowery

et al. 2023

A&D Transl Res & Clin Interv

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Introduction: Alzheimer's disease (AD) occurs in aging adults with Down syndrome (DS) at a higher prevalence and an earlier age than in typical aging adults. As with the general aging adult population, there is an urgent need to understand the preclinical and early phases of AD progression in the adult population with DS. The aim of this scoping review was to synthesize the current state of the evidence and identify gaps in the literature regarding functional activity performance and falls and their significance to disease staging (i.e., mild, moderate, and severe defined staging criteria) in relation to Alzheimer's disease and related dementias (ADRD) in adults with DS.Methods: This scoping review included six electronic databases (e.g., PsycInfo, Academic Search Complete, CINAHL, COCHRANE Library, MEDLINE, and PubMed).Eligible studies included participants with DS ≥25 years of age, studies with functional measures and/or outcomes (e.g., activities of daily living, balance, gait, motor control, speech, behavior, and cognition; falls; and fall risks), and studies that investigated AD pathology and implications.Results: Fourteen eligible studies were included and categorized through a thematic analysis into the following themes: (1) physical activity and motor coordination (PAMC), (2) cognition, (3) behavior, and (4) sleep. The studies indicated how functional activity performance and engagement may contribute to early identification of those at risk of cognitive decline and AD development and/or progression.Discussion: There is a need to expand the research regarding ADRD pathology relative to functional outcomes in adults with DS. Functional measures related to disease staging and cognitive impairment are essential to understanding how AD progression is characterized within real-world settings. This scoping review identified the need for additional mixed-methods research to examine the use of assessment and intervention related to function and its detection of cognitive decline and AD progression.

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Section: Discussionmentioning

confidence: 99%

Section: Physical Activity and Motor Coordinationmentioning

confidence: 99%

Section: Ds the Estimated Number Of Individuals With Ds Living In The...mentioning

confidence: 99%

Section: Physical Activity and Motor Coordinationmentioning

confidence: 99%

Section: Current Evidence Of the Risk Of Falling And Fallsmentioning

confidence: 99%

See 3 more Smart Citations

Down syndrome and Alzheimer's disease: A scoping review of functional performance and fall risk

Washington

Cler

Lowery

et al. 2023

A&D Transl Res & Clin Interv

View full text Add to dashboard Cite

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Balance and Gait

Conceição,

Sant´Ana,

Mattar

et al. 2023

Alzheimer Disease &Amp; Associated Disorders

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Background: Atypical aging in Down syndrome (DS) is associated with neuropathological characteristics consistent with Alzheimer disease. Gait abnormalities have been shown to be associated with an increased risk of dementia for the general population. The aim of this study was to determine whether gait disorders are associated with worse cognitive performance and dementia in adults with DS. Methods: We evaluated 66 individuals with DS (≥20 y of age), divided into 3 groups: stable cognition, prodromal dementia, and dementia (presumed Alzheimer disease). Each individual was evaluated with the Performance-Oriented Mobility Assessment (POMA), Timed Up and Go test, and Cambridge Examination for Mental Disorders of Older People with Down’s Syndrome and Others with Intellectual Disabilities (CAMDEX-DS), in addition to a comprehensive clinical protocol to ascertain the occurrence of medical or psychiatric comorbidities. Results: The score on the POMA-Gait subscale score and body mass index were found to be independent predictors of prodromal dementia and dementia (P<0.001 for both). With the exception of perception, all cognitive domains correlated with the POMA-Total score (P<0.05). Conclusion: A lower POMA-Gait score increases the chance of prodromal dementia and dementia in adults with DS. Unlike other research, in this study higher body mass index was also found to increase the chance of prodromal dementia and dementia. In those individuals, applying the POMA could facilitate the early diagnosis of dementia, help identify fall risks, and promote the adoption of geriatric interventions focused on improving functional mobility.

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Scoping review of dual-task interference in individuals with intellectual disability

Pineda,

Krampe,

Vanlandewijck

et al. 2023

Front. Psychol.

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Dual-task paradigms can provide insights on the structures and mechanisms underlying information processing and hold diagnostic, prognostic, and rehabilitative value for populations with cognitive deficits such as in individuals with intellectual disability (ID). In this paradigm, two tasks are performed separately (single-task context) and concurrently (dual-task context). The change in performance from single- to dual-task context represents dual-task interference. Findings from dual-task studies have been largely inconsistent on whether individuals with ID present with dual-task-specific deficits. The current review aimed to map the published literature on dual-task methods and pattern of dual-task interference in individuals with ID. A scoping review based on Arksey and O’Malley’s five-stage methodological framework was performed. Seventeen electronic databases and registries were searched to identify relevant studies, including gray literature. Charted data from included studies were analyzed quantitatively and qualitatively. PRISMA guidelines informed the reporting of this review. Twenty-two studies involving 1,102 participants (656 with ID and 446 without ID) met the review’s inclusion criteria. Participants in the included studies were heterogeneous in sex, age (range 3–59 years), etiology and ID severity. Included studies characterized their ID-sample in different ways, most commonly using intelligence quotient (IQ) scores. Other measures of intellectual function (e.g., mental age, ID severity, verbal and/or visuospatial ability scores) were also used, either solely or in combination with IQ. Methods of dual-task testing varied across studies, particularly in relation to dual-task combinations, equation of single-task performance between groups, measurement and reporting of dual-task performance for each single-task, and task priority instructions. Thematic content of the included studies were: (1) structural interference to dual-tasking; (2) etiology-based differences in dual-tasking; (3) gait and balance dual-task performance; (4) testing executive function using dual-task paradigms; and (5) training effect on dual-task performance. Although the evidence consistently supported the intact dual-tasking ability of individuals with ID, the pattern of dual-task interference was inconsistent. Likewise, the evidence was inconclusive regarding dual-task deficit specific to individuals with ID because of heterogeneity in dual-task study designs among included studies.

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Feasibility of dual‐task gait to estimate Alzheimer's related cognitive decline in Down syndrome

Cited by 3 publications

References 43 publications

Down syndrome and Alzheimer's disease: A scoping review of functional performance and fall risk

Down syndrome and Alzheimer's disease: A scoping review of functional performance and fall risk

Balance and Gait

Scoping review of dual-task interference in individuals with intellectual disability

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