Feasibility of diffusional kurtosis tensor imaging in prostate MRI for the assessment of prostate cancer: Preliminary results

Quentin, Michael; Pentang, Gael; Schimmöller, Lars; Kott, Olga; Müller‐Lutz, Anja; Blondin, D.; Arsov, Christian; Hiester, Andreas; Robert, René; Wittsack, Hans‐Jörg

doi:10.1016/j.mri.2014.04.005

Cited by 54 publications

(42 citation statements)

References 29 publications

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“…Current clinical applications of DTI for prostate cancer are focused predominantly on differentiation of tumor from normal prostate gland [ 7 – 13 ] and slightly on the assessment of tumor aggressiveness with respect to GS [ 14 – 16 ]. A wide range of MD and FA values from prostate tumor foci has been reported.…”

Section: Introductionmentioning

confidence: 99%

“…A wide range of MD and FA values from prostate tumor foci has been reported. Most of the studies show that FA of prostate tumor foci is higher than the one of noncancerous prostate tissue [ 7 – 10 ] while lower or equal FA values have been also reported in some studies [ 10 – 13 ]. The variability in DTI measures can be mainly due to the uncertainties during imaging.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Peripheral Zone Prostate Cancer Aggressiveness Using the Ratio of Diffusion Tensor Imaging Measures

Onay

Ertas

Vural

et al. 2017

Contrast Media & Molecular Imaging

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.Purpose. To evaluate the aggressiveness of peripheral zone prostate cancer by correlating the Gleason score (GS) with the ratio of the diffusion tensor imaging (DTI) measures. Materials and Methods. Forty-two peripheral zone prostate tumors were imaged using DTI. Regions of interest focusing on the center of tumor foci and noncancerous tissue were used to extract statistical measures of mean diffusivity (MD) and fractional anisotroy (FA). Measure ratio was calculated by dividing tumor measure by noncancerous tissue measure. Results. Strong correlations are observable between GS and MD measures while weak correlations are present between GS and FA measures. Minimum tumor MD (MD min ) and the ratio of minimum MD (rMD min ) show the same highest correlation with GS (both = −0.73). Between GS ≤ 7 (3 + 4) and GS ≥ 7 (4 + 3), differences are significant for all MD measures but for some FA measures. MD measures perform better than FA measures in discriminating GS ≥ 7 (4 + 3). Conclusion. Ratios of MD measures can be used in evaluation of peripheral zone prostate cancer aggressiveness; however tumor MD measures alone perform similarly.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of Peripheral Zone Prostate Cancer Aggressiveness Using the Ratio of Diffusion Tensor Imaging Measures

Onay

Ertas

Vural

et al. 2017

Contrast Media & Molecular Imaging

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“…Several studies have highlighted the clinical benefit of DKI over DTI in the human brain, for example in the assessment of Parkinson disease or cerebral gliomas . Initial studies have demonstrated the feasibility of DKI in the abdomen, such as the kidney and prostate (Fig. ).…”

Section: Discussionmentioning

confidence: 99%

Diffusion tensor imaging in abdominal organs

Lanzman

Wittsack

2015

NMR in Biomedicine

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Initially, diffusion tensor imaging (DTI) was mainly applied in studies of the human brain to analyse white matter tracts. As DTI is outstanding for the analysis of tissue´s microstructure, the interest in DTI for the assessment of abdominal tissues has increased continuously in recent years. Tissue characteristics of abdominal organs differ substantially from those of the human brain. Further peculiarities such as respiratory motion and heterogenic tissue composition lead to difficult conditions that have to be overcome in DTI measurements. Thus MR measurement parameters have to be adapted for DTI in abdominal organs. This review article provides information on the technical background of DTI with a focus on abdominal imaging, as well as an overview of clinical studies and application of DTI in different abdominal regions. Copyright © 2015 John Wiley & Sons, Ltd.

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“…This deviation from a uniform diffusion pattern can be mathematically described as kurtosis and visualized by DKI, which applies diffusion gradients with multiple b-values in multiple spatial directions [38]. The DKI-derived metric K has been shown to be significantly different in cancer than in non-cancerous prostate tissue [39] and has also been used to differentiate high-grade from low-grade prostate cancer [40–42]. Others, however, found that the K-values of prostate cancer and benign prostatic hyperplasia showed marked overlap [43] and that DKI-derived metrics did not provide a significant benefit for detection and grading of prostate cancer when compared to standard ADC-maps [44].…”

Section: Dw-mri As a Tool For Risk-assessmentmentioning

confidence: 99%

The expanding landscape of diffusion-weighted MRI in prostate cancer

et al. 2016

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The added value of diffusion-weighted magnetic resonance imaging (DW-MRI) for the detection, localization, and staging of primary prostate cancer has been extensively reported in original studies and meta-analyses. More recently, DW-MRI and related techniques have been used to non-invasively assess prostate cancer aggressiveness and estimate its biological behavior. The present article aims to summarize the potential applications of DW-MRI for non-invasive optimization of pretherapeutic risk assessment, patient management decisions, and evaluation of treatment response.

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Feasibility of diffusional kurtosis tensor imaging in prostate MRI for the assessment of prostate cancer: Preliminary results

Cited by 54 publications

References 29 publications

Evaluation of Peripheral Zone Prostate Cancer Aggressiveness Using the Ratio of Diffusion Tensor Imaging Measures

Evaluation of Peripheral Zone Prostate Cancer Aggressiveness Using the Ratio of Diffusion Tensor Imaging Measures

Diffusion tensor imaging in abdominal organs

The expanding landscape of diffusion-weighted MRI in prostate cancer

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