Feasibility of diffusion and probabilistic white matter analysis in patients implanted with a deep brain stimulator

Mapping Motor Pathways in Parkinson’s Disease Patients with Subthalamic Deep Brain Stimulator: A Diffusion MRI Tractography Study

“…However, research on the safety of DTI sequences with DBS device implantation remains limited. Both our present study and a recent study [15] suggest that scanning of DTI sequences with a DBS device is safe under a 1.5-T MR scanner.…”

“…VTA volumes of tissue activated, NSP nigrostriatal pathway total acquisition time by setting a relatively short repetition time (6500 ms) while the SAR value under the recommended threshold level (0.4 W/kg) [19]. Compared with the recent study, in which it took about 25 min to acquire postoperative DTI images for tractography [15], our results show that clinically useful DTI images can be acquired within a relatively short amount of time. Given that the access to MR scanners in most centers is limited and that the long duration of scanning may make patients feel restless [33], the proposed 10-min scanning protocol in our study is more efficient and clinically practical than the 25-min protocol proposed in a previous study [15], which can facilitate the examination of the white matter tracts around the stimulation contacts in future research.…”

Ventralis intermedius nucleus anatomical variability assessment by MRI structural connectivity

“…Methods developed to augment neurosurgical targeting will only be translational if they are robust to artifacts and reflect only true anatomical variability, to ensure safety and efficacy in their application. While HCP data has been pre-processed to correct for motion artefacts, the fact that DWI is extremely sensitive to movement ( Baum et al., 2018 ; Le Bihan et al., 2006 ; Ling et al., 2012 ; Muller et al., 2020 ; Tijssen et al., 2009 ) drove efforts in this work to establish the influence of subject movement on eventual observed Vim variability.…”

Bringing Advanced Therapies for Parkinson’s Disease to the Clinic: An Analysis of Ethical Issues

“…In DBS, electrodes are surgically implanted into the subthalamic nucleus and globus pallidus —a procedure associated with adverse effects such as the worsening of cognitive, motor or psychiatric symptoms and cerebral hemorrhages or stroke [ 16 ]. The mechanisms behind the underlying efficacy of DBS are not well understood [ 17 ], and unexpected harms can sometimes be induced [ 18 ]. Although DBS is considered a “reversible” treatment, there are concerns that non-stimulation-dependent effects of DBS can occur [ 19 ].…”