Feasibility of correlation mapping optical coherence tomography angiographic technique using a 200  kHz vertical-cavity surface-emitting laser source for in vivo microcirculation imaging applications

Lal, Cerine; Subhash, Hrebesh M.; Alexandrov, Sergey; Leahy, Martin J.

doi:10.1364/ao.57.00e224

Cited by 3 publications

(2 citation statements)

References 52 publications

(61 reference statements)

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“…39 Angiographic OCT is a functional extension of OCT that was developed to image microvasculature. [40][41][42][43][44][45][46] We have utilized angiographic OCT to assess the effects of prenatal exposure to one dose of ethanol, 47 a synthetic cannabinoid, 48 and nicotine on the fetal brain. 49 This study uses correlation mapping optical coherence angiography (cm-OCA) 50 to assess dose-dependent fetal brain vasculature changes due to maternal exposure to ethanol in a mouse model in utero.…”

Section: Introductionmentioning

confidence: 99%

Dose-response analysis of microvasculature changes in the murine fetal brain and the maternal extremities due to prenatal ethanol exposure

et al. 2020

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Significance: Prenatal exposure to ethanol causes several morphological and neurobehavioral deficits. While there are some studies on the effects of ethanol exposure on blood flow, research focusing on acute changes in the microvasculature is limited. Aim: The first aim of this study was to assess the dose-dependent changes in murine fetal brain microvasculature of developing fetuses in response to maternal alcohol consumption. The second aim was to quantify changes in vasculature occurring concurrently in the mother's hindlimb and the fetus's brain after maternal exposure to alcohol. Approach: Correlation mapping optical coherence angiography was used to evaluate the effects of prenatal exposure to different doses of ethanol (3, 1.5, and 0.75 g∕kg) on murine fetal brain vasculature in utero. Additionally, simultaneous imaging of maternal peripheral vessels and the fetal brain vasculature was performed to assess changes of the vasculature occurring concurrently in response to ethanol consumption. Results: The fetal brain vessel diameters (VDs) decreased by ∼47%, 30%, and 14% in response to ethanol doses of 3, 1.5, and 0.75 g∕kg, respectively. However, the mother's hindlimb VD increased by 63% in response to ethanol at a dose of 3 g∕kg. Conclusions: Results showed a dose-dependent reduction in vascular blood flow in fetal brain vessels when the mother was exposed to ethanol, whereas vessels in the maternal hindlimb exhibited concurrent vasodilation.

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Section: Introductionmentioning

confidence: 99%

Dose-response analysis of microvasculature changes in the murine fetal brain and the maternal extremities due to prenatal ethanol exposure

et al. 2020

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“…However, this technique is Doppler angle dependent and is not sensitive to flow in the direction perpendicular to the scanning beam. SVOCT and IB‐cmOCT , on the other hand, are intensity‐based techniques that use the variance and decorrelation of the signal intensity over time to image vasculature. Although there is no angular dependence, the processing kernel size and the intensity‐based detection paradigm may limit the vascular imaging resolution and sensitivity to small vessels.…”

Section: Introductionmentioning

confidence: 99%

Assessing the acute effects of prenatal synthetic cannabinoid exposure on murine fetal brain vasculature using optical coherence tomography

Raghunathan

Liu

Kouka

et al. 2019

Journal of Biophotonics

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Marijuana is one of the most commonly abused substances during pregnancy. Synthetic cannabinoids (SCBs) are a group of heterogeneous compounds that are 40-to 600-fold more potent than Δ 9 -tetrahydrocannabinol, the major psychoactive component of marijuana. With SCBs being legally available for purchase and the prevalence of unplanned pregnancies, the possibility of prenatal exposure to SCBs is high. However, the effects of prenatal SCB exposure on embryonic brain development are not well understood. In this study, we use complex correlation mapping optical coherence angiography to evaluate changes in murine fetal brain vasculature in utero, minutes after maternal exposure to an SCB, CP-55940. Results showed a significant decrease (P < 0.05) in fetal brain vessel diameter, length fraction and area density when compared to the sham group. This preliminary study shows that acute prenatal exposure to an SCB resulted in significant fetal brain vasoconstriction during the peak period for brain development. K E Y W O R D S brain vasculature, murine embryos, optical coherence tomography, prenatal cannabinoid exposure, synthetic cannabinoids

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Optical coherence tomography angiography to evaluate murine fetal brain vasculature changes caused by prenatal exposure to nicotine

Raghunathan

Liu

Ambekar

et al. 2020

Biomed. Opt. Express

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Maternal smoking causes several defects ranging from intrauterine growth restriction to sudden infant death syndrome and spontaneous abortion. While several studies have documented the effects of prenatal nicotine exposure in development and behavior, acute vasculature changes in the fetal brain due to prenatal nicotine exposure have not been evaluated yet. This study uses correlation mapping optical coherence angiography to evaluate changes in fetal brain vasculature flow caused by maternal exposure to nicotine during the second trimester-equivalent of gestation in a mouse model. The effects of two different doses of nicotine were evaluated. Results showed a decrease in the vasculature for both doses of nicotine, which was not seen in the case of the sham group.

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Feasibility of correlation mapping optical coherence tomography angiographic technique using a 200 kHz vertical-cavity surface-emitting laser source for in vivo microcirculation imaging applications

Cited by 3 publications

References 52 publications

Dose-response analysis of microvasculature changes in the murine fetal brain and the maternal extremities due to prenatal ethanol exposure

Dose-response analysis of microvasculature changes in the murine fetal brain and the maternal extremities due to prenatal ethanol exposure

Assessing the acute effects of prenatal synthetic cannabinoid exposure on murine fetal brain vasculature using optical coherence tomography

Optical coherence tomography angiography to evaluate murine fetal brain vasculature changes caused by prenatal exposure to nicotine

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