Abstract:Standard diffusion MRI model with intra-and extra-axonal water pools offers a set of microstructural parameters describing brain white matter architecture. However, a non-linearity of the general model and diffusion data contamination by noise and imaging artefacts make estimation of diffusion metrics challenging. In order to develop reproducible and reliable diffusion approaches and to avoid computational model degeneracy, one needs to devise additional theoretical assumptions allowing a stable numerical impl… Show more
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