Feasibility of adding magnesium to intrathecal fentanyl in pediatric cardiac surgery

Atallah, M. M.; Saber, Hosam I. El Said; Mageed, Nabil A; Motawea, Abdel-Aziz A.; Alghareeb, Nawal Abdelgalil

doi:10.1016/j.egja.2011.06.004

Cited by 3 publications

(2 citation statements)

References 22 publications

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“…MgSO 4 (20-50 mgÁkg À1 AE 5-20 mgÁkg À1 Áh À1 ) reduces the need for sedative-hypnotic drugs during general anesthesia: it can decrease the sevoflurane minimum Sedation Sedation (IV) (2,6) 20-50 mgÁkg À1 AE 5-20 mgÁkg À1 Áh À1 Agitation/Shivering (IV) (7-10) 20-50 mgÁkg À1 AE 5-20 mgÁkg À1 Áh À1 Convulsions (IV) (16) 50 mgÁkg À1 + 10-40 mgÁkg À1 Áh À1 Analgesia Analgesia (IV) (17-21) 30-50 mgÁkg À1 AE 5-20 mgÁkg À1 Áh À1 Local analgesia (peritonsillar) (14,23) 2-5 mgÁkg À1 Epidural analgesia (caudal) (5,15,25) 50 mg (total dose) Spinal analgesia (intrathecal) (26) 0.5-1 mgÁkg À1…”

Section: Sedationunclassified

“…Moreover, epidural MgSO 4 (total dose of 50 mg)—as an adjuvant in caudal blockade—improves and prolongs the analgesic effect of local anesthetics, enhances functional recovery after blockade, and prevents emergence agitation . Additionally, intrathecal MgSO 4 (0.5–1 mg·kg −1 ) reduces perioperative analgesic consumption in open heart surgery and also shortens postoperative extubation time .…”

Section: Magnesium Sulfate In Pediatric Anesthesiamentioning

confidence: 99%

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Magnesium sulfate in pediatric anesthesia: the Super Adjuvant

Rebollar

Palacios

Guerrero

et al. 2017

Pediatric Anesthesia

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Magnesium is an essential chemical element in all organisms, intervening in most cellular enzymatic reactions; thus, its importance in homeostasis and as a therapeutic tool in highly challenging patients such as pediatrics. The primary purpose of this paper was to review the role of magnesium sulfate as an adjuvant drug in pediatric anesthesia. This compound already has the scientific backing in certain aspects such as analgesia or muscle relaxation, but only theoretical or empirical backing in others such as organ protection or inflammation, where it seems to be promising. The multitude of potential applications in pediatric anesthesia, its high safety, and low cost make magnesium sulfate could be considered a Super Adjuvant.

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Section: Sedationunclassified

Section: Magnesium Sulfate In Pediatric Anesthesiamentioning

confidence: 99%

Magnesium sulfate in pediatric anesthesia: the Super Adjuvant

Rebollar

Palacios

Guerrero

et al. 2017

Pediatric Anesthesia

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Fast-Tracking and Regional Anesthesia in Pediatric Patients Undergoing Congenital Heart Surgery

Mittnacht¹,

Rodriguez-Diaz²

2013

Pediatric and Congenital Cardiology, Cardiac Surgery and Intensive Care

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Magnesium Supplementation Reduces Postoperative Arrhythmias After Cardiopulmonary Bypass in Pediatrics: A Metaanalysis of Randomized Controlled Trials

2013

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Postoperative arrhythmia (POA) is the most common complication encountered after cardiopulmonary bypass (CPB). The preventive effect of magnesium in POA has been confirmed by metaanalyses in adults, but less is known in pediatric patients. A metaanalysis of published trials was conducted to examine the efficacy of magnesium supplementation in POA prevention among pediatric patients undergoing CPB. Relevant trials were identified from electronic databases (Medline, Embase, Web of Science, and Cochrane library). Pooled relative risk (RR) and 95 % confidence intervals (CI) were calculated using Mantel-Haenszel random-effects models, and heterogeneity was determined qualitatively according to I (2) and chi-squared statistical analyses. Among 121 potentially relevant studies, five randomized controlled trials met the inclusion criteria, resulting in a pooled total of 348 participants. Compared with placebo, magnesium supplementation decreased the incidence of arrhythmia after CPB in pediatric patients by 66 % (RR, 0.34; 95 % CI, 0.18-0.65; P = 0.001), with no heterogeneity between trials (heterogeneity P = 0.68; I (2) = 0 %). Magnesium supplementation significantly reduces the incidence of postoperative arrhythmias in pediatric patients undergoing CPB. Although the findings encourage the use of magnesium as an alternative to postoperative arrhythmias after CPB in pediatric patients, higher-quality randomized clinical trials are necessary before the findings can be generalized.

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Feasibility of adding magnesium to intrathecal fentanyl in pediatric cardiac surgery

Cited by 3 publications

References 22 publications

Magnesium sulfate in pediatric anesthesia: the Super Adjuvant

Magnesium sulfate in pediatric anesthesia: the Super Adjuvant

Fast-Tracking and Regional Anesthesia in Pediatric Patients Undergoing Congenital Heart Surgery

Magnesium Supplementation Reduces Postoperative Arrhythmias After Cardiopulmonary Bypass in Pediatrics: A Metaanalysis of Randomized Controlled Trials

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