Feasibility of ablative fractional laser-assisted drug delivery with optical coherence tomography

Yang, Chih‐Hsun; Tsai, Meng‐Tsan; Shen, Su‐Chin; Ng, Chau Yee; Jung, Shih‐Ming

doi:10.1364/boe.5.003949

Cited by 17 publications

(15 citation statements)

References 49 publications

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“…An earlier study demonstrated proofof-concept with four different lasers [14] and this has been followed up with further work using millisecond-pulsed CO 2 lasers. In one case, nails were imaged post-poration with optical coherence tomography; in another, application of a topical cream to porated nails produced a positive treatment effect in nearly all patients [15,16]. However, exposure to laser ablation was not without noticeable pain, probably because the long pulse duration caused local heating.…”

Section: Introductionmentioning

confidence: 99%

Precise laser poration to control drug delivery into and through human nail

Vanstone

Cordery

Stone

et al. 2017

Journal of Controlled Release

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Drug treatment of diseases of the human nail remains a difficult challenge; topical therapy, in particular, is limited by very poor transport of active agents across the nail itself. The objective of this research was to examine the potential of controlled, and fibre-optic delivered, femtosecond laser light pulses to provide new pathways and opportunities for drug access to targets within and beneath the nail plate. Optical, confocal fluorescence and scanning electron microscopies demonstrated partial and complete laser poration of human nail samples, with the energy per pore and the exposure duration being the key modulating parameters that determined the extent of ablation achieved. Parallel measurements of the penetration of a model drug across laser-treated nails showed that complete poration resulted in essentially complete circumvention of the diffusion barrier, an array of 100 pores in 0.2cm area of nail permitting a 10-fold increase in initial drug uptake. Partial ablation of the nail created pores that extended to a range of depths; the nail material adjacent to the ablated area was rendered porous in appearance presumably due to local thermal perturbation of the nail structure. These openings offer, as a result, potential sites in which topical drug formulations might be sequestered post-poration and from which slow, sustained delivery of the active agent into and through the nail may be envisaged.

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Section: Introductionmentioning

confidence: 99%

Precise laser poration to control drug delivery into and through human nail

Vanstone

Cordery

Stone

et al. 2017

Journal of Controlled Release

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“…The setup of the SS-OCT system is similar to that of a previous study [42]. A swept source (HSL-20, Santec Corp., Aichi, Japan) at 1.3 μm was used as the light source of the OCT system with a scanning spectrum of 110 nm.…”

Section: Experiments Methods and Setupmentioning

confidence: 99%

“…In previous studies, we have demonstrated that the photothermolysis of human skin induced by an ablative laser can be monitored with OCT [41]. Furthermore, preliminary OCT results have proven the feasibility of laser-assisted therapy [42]. In this study, we investigate the time-dependent variation of OCT intensity during the diffusion process of drug particles.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Laser-Assisted Trans-Nail Drug Delivery with Optical Coherence Tomography

Tsai

Shen

et al. 2016

Sensors

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The nail provides a functional protection to the fingertips and surrounding tissue from external injuries. The nail plate consists of three layers including dorsal, intermediate, and ventral layers. The dorsal layer consists of compact, hard keratins, limiting topical drug delivery through the nail. In this study, we investigate the application of fractional CO2 laser that produces arrays of microthermal ablation zones (MAZs) to facilitate drug delivery in the nails. We utilized optical coherence tomography (OCT) for real-time monitoring of the laser–skin tissue interaction, sparing the patient from an invasive surgical sampling procedure. The time-dependent OCT intensity variance was used to observe drug diffusion through an induced MAZ array. Subsequently, nails were treated with cream and liquid topical drugs to investigate the feasibility and diffusion efficacy of laser-assisted drug delivery. Our results show that fractional CO2 laser improves the effectiveness of topical drug delivery in the nail plate and that OCT could potentially be used for in vivo monitoring of the depth of laser penetration as well as real-time observations of drug delivery.

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“…[80][81][82][83][84][85][86] OCT is able to visualize the nail plate, nail bed, and nail matrix, 87 and the method has been using for assessing effectiveness of transnail drug delivery using ablative fractional laser with OCT, suggesting the technology to be an effective tool for monitoring both depth of laser penetration and drug delivery efficacy in nails. 80,81 Measurement of nail thickness with OCT has been applied, showing lower degrees of variation compared to ultrasonography, 87 though lacking the ability to visualize single cellular structures compared to confocal laser scanning microscopy. 88 A "demonstration of principle" study to assist the planning of follicular unit extraction with OCT has been made in order to easily evaluate the angles of hair follicles during hair transplants.…”

Section: Physiological Studiesmentioning

confidence: 99%

Advances in optical coherence tomography in dermatology—a review

2018

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Optical coherence tomography (OCT) was introduced as an imaging system, but like ultrasonography, other measures, such as blood perfusion and polarization of light, have enabled the technology to approach clinical utility. This review aims at providing an overview of the advances in clinical research based on the improving technical aspects. OCT provides cross-sectional and en face images down to skin depths of 0.4 to 2.00 mm with optical resolution of 3 to 15 μm. Dynamic optical coherence tomography (D-OCT) enables the visualization of cutaneous microvasculature via detection of rapid changes in the interferometric signal of blood flow. Nonmelanoma skin cancer (NMSC) is the most comprehensively investigated topic, resulting in improved descriptions of morphological features and diagnostic criteria. A refined scoring system for diagnosing NMSC, taking findings from conventional and D-OCT into account, is warranted. OCT diagnosis of melanoma is hampered by the resolution and the optical properties of melanin. D-OCT may be of value in diseases characterized with dynamic changes in the vasculature of the skin and the addition of functional measures is strongly encouraged. In conclusion, OCT in dermatology is still an emerging technology that has great potential for improving further in the future.

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Feasibility of ablative fractional laser-assisted drug delivery with optical coherence tomography

Cited by 17 publications

References 49 publications

Precise laser poration to control drug delivery into and through human nail

Precise laser poration to control drug delivery into and through human nail

Evaluation of Laser-Assisted Trans-Nail Drug Delivery with Optical Coherence Tomography

Advances in optical coherence tomography in dermatology—a review

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