Feasibility of 177Lu Therapy Monitoring Using Fast Whole-Body SPECT Recordings Provided by a High-Speed 360° CZT Camera

Abstract

The whole-body absolute quantification of 177Lu-DOTATATE therapy was achieved using a high-speed 360° CZT SPECT/CT system. Twelve high-resolution swelling detectors may be positioned close to patients, providing a high-count sensitivity that is particularly advantageous for the low-count rate conditions of 177Lu imaging. After initially validating 177Lu quantification on phantom, serial whole-body SPECT/CT acquisitions of only 20 minutes were obtained for a 70-year-old woman treated by 177Lu-DOTATATE injections for a metastatic recurrence of a pancreatic neuroendocrine tumor. The progressive decrease in tumor uptake between the consecutive 177Lu-DOTATATE injections could be quantified, and thereby the corresponding dosimetry changes could be estimated.

Novel theranostic agent for PET imaging and targeted radiopharmaceutical therapy of tumour-infiltrating immune cells in glioma

“…Similarly, we envision image-guided dosimetry with 89 Zr-Lumi804-αCD11b to set safe levels for 177 Lu-Lumi804-αCD11b. Advances in imaging technology, particularly in the clinical setting, such as the incorporation of cadmium-zinc-telluride (CZT) cameras into modern SPECT are allowing for increased sensitivity and imaging speed to calculate dosimetry based upon 177 Lu-Lumi804-αCD11b, without the need for a separate PET radiotracer [60] .…”

Targeted therapy monitoring of BRAF-V600-mutant Erdheim-Chester disease by fast quantitative whole-body bone CZT-tomoscintigraphies

“…18 F-FDG PET is now considered to be the reference technique for whole-body assessment of ECD patients (Kirchner et al 2021). At the present time, however, fast whole-body recordings and reliable standardized uptake values (SUV) measurements may be obtained not only with PET cameras but also with novel hybrid systems combining: (i) single-photon emission tomography (SPECT) recording through cadmium-zinc-telluride (CZT) detectors with an original 360° ring configuration geometry that is likely to maximize both count sensitivity and image quality and (ii) multi-detector computed tomography (CT) scanners providing the attenuation maps required for SUV quantification (Melki et al 2020;Bahloul et al 2021;Mairal et al 2022;Chevalier et al 2020). One such system, the high-speed VERITON CZT-SPECT/CT system (Spectrum Dynamics Medical, Caesarea, Israel) was previously shown to provide Melki et al European Journal of Hybrid Imaging (2023) 7:1 both reliable SUV measurements and high-quality bone scintigraphy images (Melki et al 2020;Bahloul et al 2021;Mairal et al 2022).…”

Bone Scintigraphy of Vertebral Fractures With a Whole-Body CZT Camera in a PET-Like Utilization

“…All these previous quantitative bone SPECT studies were conducted with conventional Anger cameras, and none has presented an image display using an SUV scale and with whole-body recording times adapted to routine clinical use. These limitations could be overcome with a new high-speed whole-body CZT camera, which has the advantages of not only enhancing image quality but also reducing SPECT recording times, thus enabling a whole-body acquisition in <20 min (12,13), similar to recording times currently achieved for PET imaging.…”

“…In particular, the whole-body VERITON R camera (Spectrum Dynamics Medical, Caesarea, Israel) combines CZT detectors with an original 360 • ring-configuration geometry that is likely to maximize both count sensitivity and image quality (12)(13)(14). Absolute quantification has also been developed with this camera and applied on lutetium-177 imaging (13), although as yet there has not been any assessment for routine bone scintigraphy.…”