Feasibility, complications, and quality of visualization using video capsule endoscopy in 40 dogs with overt or questionable gastrointestinal bleeding

Stiller, Jenny; Defarges, Alice; Brisson, Brigitte A.; Bersenas, Alexa M E; Pearl, David L.

doi:10.1111/jvim.16153

Cited by 6 publications

(14 citation statements)

References 49 publications

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“…In our study, 35% VCE recordings of the 276 dogs without definitive AGD were incomplete, which is comparable to the rate of 13% to 47% of incomplete studies published so far in the veterinary literature. 19 , 21 , 22 Consequently, AGD could have been missed in some of these dogs. In humans, several risk factors, such as GIB, have been associated with incomplete studies.…”

Section: Discussionmentioning

confidence: 99%

“… 40 A high‐fat diet, chronic enteropathy, and recent use of opioids may increase the risk of incomplete studies in dogs. 19 The use of prokinetics might be beneficial. 41 …”

Section: Discussionmentioning

confidence: 99%

“…The use of VCE has become more popular in dogs as a minimally invasive tool to detect GIB. 19 , 20 , 21 , 22 , 23 This procedure is well tolerated in dogs and yields a diagnosis in over 75% of dogs with overt GIB. 19 Because repeating VCE is less expensive and invasive than conventional endoscopy and surgical exploration, it is also a promising test for intermittent GIB.…”

Section: Introductionmentioning

confidence: 99%

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Gastrointestinal angiodysplasias diagnosed using video capsule endoscopy in 15 dogs

Defarges

Stiller

Solomon³

2023

Veterinary Internal Medicne

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Background Angiodysplasia (AGD) is rarely diagnosed in dogs with gastrointestinal bleeding (GIB) and is reported in case reports in dogs. Objective Describe signalment, clinical and diagnostic features of dogs with gastrointestinal (GI) AGD diagnosed by video capsule endoscopy (VCE). Animals Dogs with overt or suspected GIB which underwent VCE. Methods Dogs for which a VCE was submitted for overt or suspected GIB from 2016 to 2021 were selected retrospectively. Medical records and full‐length VCE recordings where AGDs were initially detected, were reviewed by 2 trained internists. AGD was considered definitive if 2 readers detected it. Signalment, clinical signs, blood work, medications, concurrent diseases, findings of previous conventional endoscopy, and surgical exploration (if applicable) of dogs with AGD were recorded. Results Definitive AGD was diagnosed in 15 of 291 (5%) dogs (12 males, 3 females). Twelve (80%) had overt GIB, 11 (73%) had hematochezia, and 6 (40%) had microcytic and hypochromic anemia. AGD was missed by conventional endoscopy in 9/9 dogs and exploratory surgery in 3/3 dogs. Thirteen capsules were administered by mouth (1 incomplete study), and 2 via endoscopy directly into the duodenum. AGD was visualized in the stomach of 3 dogs, in the small intestine of 4, and in the colon of 13 dogs. Conclusion and Clinical Importance Although rare, AGD should be considered in dogs with suspected GIB after a negative conventional endoscopy or surgical exporation. Video capsuel endoscopy appears to be a sensitive test to identify AGD within the GI tract.

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Section: Discussionmentioning

confidence: 99%

“… 40 A high‐fat diet, chronic enteropathy, and recent use of opioids may increase the risk of incomplete studies in dogs. 19 The use of prokinetics might be beneficial. 41 …”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Gastrointestinal angiodysplasias diagnosed using video capsule endoscopy in 15 dogs

Defarges

Stiller

Solomon³

2023

Veterinary Internal Medicne

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“…These authors 21 concluded that use of this capsule to monitor gastric emptying times should be limited to dogs weighing ≥ 15 kg. In a study 22 in which video capsule endoscopy was used in dogs, the authors reported that the capsules were retained in the stomach for > 6 hours in 39% of the dogs, resulting in an incomplete study.…”

Section: Discussionmentioning

confidence: 99%

Effects of housing environment on oral absorption of acetaminophen in healthy Beagles

Madsen

Enomoto

Messenger

et al. 2022

ajvr

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OBJECTIVE To evaluate the effects of housing environment on oral absorption of acetaminophen in dogs. ANIMALS 6 healthy Beagles. PROCEDURES Acetaminophen (325 mg, PO; mean dose, 31.1 mg/kg) was administered in a crossover study design with dogs housed in their normal environment or in a cage in an unfamiliar environment. There was a 7-day washout period between phases. Blood samples were collected for 24 hours following acetaminophen administration, and plasma acetaminophen concentrations were determined with high-pressure liquid chromatography. RESULTS A 2-compartment model with lag time was the best fit for both phases of the study. None of the primary or secondary pharmacokinetic parameters were significantly different between the 2 housing environments. CLINICAL RELEVANCE Findings suggested that in dogs, housing environment (normal environment vs a cage in an unfamiliar environment) did not significantly affect oral absorption and, by extension, gastric emptying of acetaminophen.

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“…In these cases, the final diagnosis was made by histopathological examination of resected specimens. Nevertheless, capsule endoscopy has been also used in dogs, and the site of gastrointestinal bleeding could be localized in 24 out of 39 recordings [ 40 ]. Unfortunately, the final diagnosis brought by biopsy, is currently not technically available with capsule endoscopy.…”

Section: Discussionmentioning

confidence: 99%

Life-threatening gastrointestinal bleeding caused by jejunal heterotopic gastric mucosa in an adult dog: a rare case report

Merca

Richter

2022

BMC Vet Res

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Background Heterotopic gastric mucosa has been scarcely reported in the veterinary literature. Its presence can be asymptomatic or associated with various clinical signs ranging from apathy, vomiting, to abdominal pain. This report illustrates the presence of heterotopic gastric mucosa in the jejunum of an adult dog. It is the first to describe severe anemia, requiring acute blood transfusion, following intestinal hemorrhage caused by heterotopic gastric mucosa. Case presentation A twelve-year-old, intact male Maltese dog was presented with a history of apathy, vomiting and anemia. The dog was on a strict diet for recurrent diarrhea, food intolerance and skin allergy. Clinical examination revealed severe anemic mucous membranes and painful abdominal palpation. Blood examination confirmed severe regenerative anemia. Ultrasonography showed an intestinal neoplasm, gall bladder sludge and non-homogeneous liver parenchyma. Three-view thoracic radiographs failed to show any metastatic lesions or enlarged lymph nodes. After initial stabilization and blood transfusion, a midline exploratory laparotomy was performed. Three different masses were found in the jejunum. Resection and anastomosis of approximately 40 cm of jejunum was performed, followed by liver and lymph node biopsy and placement of an esophagostomy tube. Two days after surgery the dog started to clinically improve and was discharged from the hospital on the sixth day after surgery. Histopathology revealed the intestinal masses to be heterotopic gastric mucosa associated with intramural cystic distensions, multifocal ulceration and bleeding into the intestinal lumen. Two years after surgery, the dog did not have a recurrence of anemia or gastrointestinal signs. Conclusions This case demonstrates that heterotopic gastric mucosa can be considered one of the differential diagnoses in case of severe anemia due to gastrointestinal hemorrhage and suspected intestinal tumors. Although in most described cases in literature the finding seems to be incidental on necropsy, our report shows that heterotopic gastric mucosa can be the etiology of life-threatening signs. In addition, because no recurrent diarrhea episodes occurred after surgical resection of the ectopic tissue, it is likely that the heterotopic gastric mucosa was the cause of the food intolerance signs in this dog.

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Feasibility, complications, and quality of visualization using video capsule endoscopy in 40 dogs with overt or questionable gastrointestinal bleeding

Cited by 6 publications

References 49 publications

Gastrointestinal angiodysplasias diagnosed using video capsule endoscopy in 15 dogs

Gastrointestinal angiodysplasias diagnosed using video capsule endoscopy in 15 dogs

Effects of housing environment on oral absorption of acetaminophen in healthy Beagles

Life-threatening gastrointestinal bleeding caused by jejunal heterotopic gastric mucosa in an adult dog: a rare case report

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