Feasibility assessment of using oxygen-enhanced magnetic resonance imaging for evaluating the effect of pharmacological treatment in COPD

Morgan, Alexandra R.; Parker, Geoffrey; Roberts, Caleb; Buonaccorsi, Giovanni A.; Maguire, N. C.; Cristinacce, Penny L. Hubbard; Singh, Dave; Vestbo, Jørgen; Bjermer, Leif; Jögi, Jonas; Taib, Ziad; Sarv, Janeli; Bruijnzeel, P. L. B.; Olsson, Lars; Bondesson, Eva; Nihlén, Ulf; McGrath, Deirdre M.; Young, Simon S.; Waterton, John C.; Nordenmark, Lars H.

doi:10.1016/j.ejrad.2014.08.004

Cited by 30 publications

(28 citation statements)

References 26 publications

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“…This lends some regional evidence to the possibility that bronchodilators are not always effective and can be potentially detrimental in selected regions of the lung in asthma. Similar observations have been reported in other imaging biomarker studies (22). Nevertheless, negative DR(r) can result from two other mechanisms; while a degradation of ventilation is Table 2.…”

Section: Discussionsupporting

confidence: 72%

“…Hyperpolarized gas MR imaging directly measures functional information from the lungs without ionizing radiation, and TRM is a potentially powerful tool for longitudinal and pediatric studies. Previously, oxygen-enhanced MR imaging has been used to measure changes induced by bronchodilators and corticosteroids (22). However, it is unclear to what extent this method captures changes in ventilation, as signal changes are caused by the interaction of protons with O 2 dissolved in tissue and blood (23).…”

Section: Discussionmentioning

confidence: 99%

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Regional Ventilation Changes in the Lung: Treatment Response Mapping by Using Hyperpolarized Gas MR Imaging as a Quantitative Biomarker

et al. 2017

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Section: Discussionsupporting

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Regional Ventilation Changes in the Lung: Treatment Response Mapping by Using Hyperpolarized Gas MR Imaging as a Quantitative Biomarker

et al. 2017

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“…Moreover, the technique was recently applied to monitoring the severity of asthma, evaluating pharmacological treatment in chronic obstructive pulmonary disease and defining candidates for lung volume reduction surgery (11)(12)(13). However, the overall magnitude of the signal enhancement from oxygen generally is weak, that is, 5% to 10% (6,7).…”

Section: Introductionmentioning

confidence: 99%

Three‐dimensional oxygen‐enhanced MRI of the human lung at 1.5T with ultra‐fast balanced steady‐state free precession

Pusterla

Bauman

Bieri

2017

Magnetic Resonance in Med

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Purpose: To assess the feasibility of 3D oxygen-enhanced (OE) MRI of the lung at 1.5T using multi-volumetric ultra-fast balanced steady-state free precession (ufSSFP) acquisitions. Methods: Isotropic imaging of the lung for OE-MRI was performed with an adapted 3D ufSSFP sequence using five breathhold acquisitions ranging from functional residual capacity to tidal inspiration under both normoxic (room air) and hyperoxic (100% O 2 ) gas conditions. For each O 2 concentration, a sponge model (which captures the parenchymal signal intensity variation as a function of the lung volume) was fitted to the acquired multivolumetric datasets after semiautomatic lung segmentation and deformable image registration. From the retrieved model parameters, 3D oxygen-enhancement maps were calculated. Results: For OE ufSSFP imaging, the maximum parenchymal signal is observed for flip angles around 23 under both normoxic and hyperoxic conditions. It is found that the sponge model accurately describes parenchymal signal at different breathing positions, thereby mitigating the confounding bias in the estimated oxygen enhancement from residual density modulations. From the model, an average lung oxygen enhancement of 7.0% 6 0.3% was found in the healthy volunteers, and the oxygenenhancement maps indicate a ventral to dorsal gravitation-related gradient. Conclusion:The study demonstrates the feasibility of wholelung OE-MRI from multi-volumetric ufSSFP in healthy volunteers.

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“…During recent years, OE-MRI has successfully been used to study patients with COPD [8,9]; chronic lung allograft dysfunction [10]; interstitial lung disease [11]; and asthma [12] as well as a murine emphysema model [13]. Several centers have also used ultra-short echo time for OE-measurements, to address the inherently low MR-signal [14–16].…”

Section: Introductionmentioning

confidence: 99%

“…49 x 10 −4 s -1 mmHg -1 [8,25]; but this applies to distilled water [5], and the value in whole blood at 1.5 Tesla is likely between 3.38 to 4.38 x 10 −4 s -1 mmHg -1, depending on the erythrocyte volume fraction (EVF) [5,26,27]. The difference in O 2 -relaxivity between blood and water can be appreciated with the Bloomberg-Purcell-Pound relaxation theory, since para- and diamagnetic relaxation is synergistic [28,29].…”

Section: Introductionmentioning

confidence: 99%

The change of longitudinal relaxation rate in oxygen enhanced pulmonary MRI depends on age and BMI but not diffusing capacity of carbon monoxide in healthy never-smokers

et al. 2017

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ObjectiveOxygen enhanced pulmonary MRI is a promising modality for functional lung studies and has been applied to a wide range of pulmonary conditions. The purpose of this study was to characterize the oxygen enhancement effect in the lungs of healthy, never-smokers, in light of a previously established relationship between oxygen enhancement and diffusing capacity of carbon monoxide in the lung (DL,CO) in patients with lung disease.MethodsIn 30 healthy never-smoking volunteers, an inversion recovery with gradient echo read-out (Snapshot-FLASH) was used to quantify the difference in longitudinal relaxation rate, while breathing air and 100% oxygen, ΔR1, at 1.5 Tesla. Measurements were performed under multiple tidal inspiration breath-holds.ResultsIn single parameter linear models, ΔR1 exhibit a significant correlation with age (p = 0.003) and BMI (p = 0.0004), but not DL,CO (p = 0.33). Stepwise linear regression of ΔR1 yields an optimized model including an age-BMI interaction term.ConclusionIn this healthy, never-smoking cohort, age and BMI are both predictors of the change in MRI longitudinal relaxation rate when breathing oxygen. However, DL,CO does not show a significant correlation with the oxygen enhancement. This is possibly because oxygen transfer in the lung is not diffusion limited at rest in healthy individuals. This work stresses the importance of using a physiological model to understand results from oxygen enhanced MRI.

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Feasibility assessment of using oxygen-enhanced magnetic resonance imaging for evaluating the effect of pharmacological treatment in COPD

Cited by 30 publications

References 26 publications

Regional Ventilation Changes in the Lung: Treatment Response Mapping by Using Hyperpolarized Gas MR Imaging as a Quantitative Biomarker

Regional Ventilation Changes in the Lung: Treatment Response Mapping by Using Hyperpolarized Gas MR Imaging as a Quantitative Biomarker

Three‐dimensional oxygen‐enhanced MRI of the human lung at 1.5T with ultra‐fast balanced steady‐state free precession

The change of longitudinal relaxation rate in oxygen enhanced pulmonary MRI depends on age and BMI but not diffusing capacity of carbon monoxide in healthy never-smokers

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