Feasibility and utility of amygdala neurofeedback

Goldway, Noam; Strauss, Ido; Keynan, Jackob Nimrod; Hellrung, Lydia; Horstmann, Annette; Paret, Christian; Hendler, Talma

doi:10.1016/j.neubiorev.2022.104694

Cited by 14 publications

(25 citation statements)

References 87 publications

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“…We expected lower amyg-EFP signal during the active regulation period relative to baseline. In addition, corresponding to previous investigations, 29,39 we expected more modulation in the last compared with the first NF sessions. Although this study was powered to find a clinical effect, in line with standard NF studies, 36,40 we exploratorily investigated whether the test group compared with the control group demonstrated greater amygdala BOLD down-regulation in rt-fMRI-NF before to after the NF training period, and whether amyg-EFP modulation correlated with clinical improvement.…”

Section: Introductionsupporting

confidence: 89%

“…28 Expanding these findings to clinical populations, a current a meta-analysis reported medium effect sizes of symptom reduction following limbic down-regulation. 29 While seemingly effective, implementing rt-fMRI-NF has a major scalability disadvantage (e.g. accessibility/mobility and affordability) that stands in its way to broadly being applied for clinical purposes in psychiatry.…”

Section: Introductionmentioning

confidence: 99%

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Amygdala‐related electroencephalogram neurofeedback as add‐on therapy for treatment‐resistant childhood sexual abuse posttraumatic stress disorder: feasibility study

Fine,

Helpman,

Armon

et al. 2023

Psychiatry Clin Neurosci

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AimChildhood sexual abuse (CSA) among women is an alarmingly prevalent traumatic experience, that often leads to debilitating and treatment‐refractory Post‐Traumatic Stress Disorder (PTSD) raising the need for novel adjunctive therapies. Neuroimaging investigations systematically report amygdala hyperactivity is the most consistent and reliable neural abnormality in PTSD and childhood abuse, raising the potential of implementing volitional neural modulation using neurofeedback (NF) aimed at down‐regulating amygdala activity. This study aimed to reliably probe limbic activity but overcome the limited applicability of functional magnetic resonance imaging (fMRI)‐NF by using a scalable EEG‐NF probe of amygdala‐related activity, termed Amygdala‐Electrical‐Finger‐Print (amyg‐EFP) in a randomized controlled trial.MethodFifty‐five female CSA‐PTSD participants that were in ongoing intensive trauma focused psychotherapy for a minimum of one year but still met the DSM‐5 PTSD criteria, were randomized to either 10 add‐on sessions of amyg‐EFP‐NF training (test group) or continuing psychotherapy (control group). Participants were blindly assessed for PTSD symptoms pre‐and‐post NF training period, followed by self‐reported clinical follow‐up at 1,3 and 6‐months, as well as one session of amygdala real‐time fMRI‐NF pre‐and‐post NF training period.ResultsParticipants in test, compared to control group demonstrated a marginally significant immediate reduction in PTSD symptoms, which progressively improved during the follow‐up period. Additionally, successful neuromodulation during NF training was demonstrated.ConclusionThis feasibility study for CSA‐PTSD treatment‐resistant patients indicates amyg‐EFP‐NF as a viable and efficient intervention.This article is protected by copyright. All rights reserved.

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Section: Introductionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Amygdala‐related electroencephalogram neurofeedback as add‐on therapy for treatment‐resistant childhood sexual abuse posttraumatic stress disorder: feasibility study

Fine,

Helpman,

Armon

et al. 2023

Psychiatry Clin Neurosci

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View full text Add to dashboard Cite

show abstract

“…Neurofeedback (NF) is a training based on reinforcement learning, empowering individuals to regulate brain activation based on feedback of brain activation (Lubianiker et al, 2022). Individuals can learn to self-modulate amygdala activation through NF, and clinical improvement with amygdala-targeted NF has been observed across different patient populations suffering from emotion dysregulation (Goldway et al, 2022). Previous proof-of-concept studies with individuals with BPD investigated amygdala self-regulation using functional Magnetic Resonance Imaging (fMRI)-based NF (Paret et al, 2016; Zaehringer et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Amygdala-related electrical fingerprint is modulated with neurofeedback training and correlates with deep-brain activation: Proof-of-concept in borderline personality disorder

Zopfs

Jindrová

Gurevitch

et al. 2023

Preprint

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Background: The modulation of brain circuits of emotion is a promising pathway to treat Borderline Personality Disorder (BPD). Precise and scalable approaches have yet to be established. Two studies investigating the Amygdala Electrical Fingerprint (Amyg-EFP) in BPD are presented: One study addressing the deep-brain correlates of Amyg-EFP, and a second study investigating neurofeedback (NF) as a means to improve brain self-regulation. Methods: Study 1 combined EEG and simultaneous fMRI to investigate the replicability of Amyg-EFP-related brain activation found in the reference dataset (N=24 healthy subjects, 8 female; re-analysis of published data) in the replication dataset (N=16 female individuals with BPD). In the replication dataset, we additionally explored how the Amyg-EFP would map to neural circuits defined by the Research Domain Criteria. Study 2 investigated a 10-session Amyg-EFP NF training in parallel to a 12-weeks residential Dialectical Behavior Therapy (DBT) program. N=15 patients with BPD completed the training, N=15 matched patients served as DBT-only controls. Results: Study 1 replicated previous findings and showed significant amygdala BOLD-activation in a whole-brain regression analysis with the Amyg-EFP. Neurocircuitry activation (negative affect, salience, and cognitive control) was correlated with the Amyg-EFP signal. Study 2 showed significant learning of Amyg-EFP modulation with NF training. No clinical benefits of NF beyond DBT-only were observed. Conclusions: Recorded via scalp EEG, the Amyg-EFP picks up brain activation of high relevance for emotion. Administering Amyg-EFP NF in addition to standardized BPD treatment was shown to be feasible. Clinical utility remains to be investigated.

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“…Dieses Verfahren befindet sich noch im experimentellen Stadium, sodass noch keine Daten zur Effektivität bei depressiven Störungen vorliegen. Ein weiterer vielversprechender Ansatz ist die Beeinflussung der Amygdala-Aktivität über ein entsprechendes Neurofeedback-Training, das auf die EEG-Signatur der Amygdala zielt [97].…”

Section: Closed-loop-neuromodulation Und Andere Neue Ansätzeunclassified

Behandlung depressiver Störungen mittels nicht invasiver Neuromodulation

Buthut¹,

Haslacher²,

Soekadar³

2023

Nervenheilkunde

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ZUSAMMENFASSUNGZur evidenzbasierten Behandlung depressiver Störungen gehören neben pharmako- und psychotherapeutischen Ansätzen auch nicht invasive Neuromodulationsverfahren. Während die Elektrokrampftherapie (EKT) in der Öffentlichkeit am bekanntesten ist, sind andere Techniken wie die transkranielle elektrische oder magnetische Stimulation (TES/TMS) weniger bekannt, auch in Fachkreisen, obwohl beispielsweise die TMS in verschiedene Behandlungsleitlinien aufgenommen wurde. Innovative Ansätze zur gezielten Modulation neuronaler Aktivität, wie die Closed-loop-Neuromodulation, bei der die Stimulationsparameter kontinuierlich an die aktuelle Hirnaktivität angepasst werden, sowie die transkranielle fokussierte Ultraschallstimulation (tFUS) und temporale Interferenzstimulation (TIS), die eine gezielte Stimulation tiefer Hirnregionen ermöglichen sollen, versprechen neue Perspektiven für die Behandlung depressiver Störungen.

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Feasibility and utility of amygdala neurofeedback

Cited by 14 publications

References 87 publications

Amygdala‐related electroencephalogram neurofeedback as add‐on therapy for treatment‐resistant childhood sexual abuse posttraumatic stress disorder: feasibility study

Amygdala‐related electroencephalogram neurofeedback as add‐on therapy for treatment‐resistant childhood sexual abuse posttraumatic stress disorder: feasibility study

Amygdala-related electrical fingerprint is modulated with neurofeedback training and correlates with deep-brain activation: Proof-of-concept in borderline personality disorder

Behandlung depressiver Störungen mittels nicht invasiver Neuromodulation

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