Feasibility and Utility of a Smartphone Application-Based Longitudinal Cough Monitoring in Chronic Cough Patients in a Real-World Setting

Lee, Seung-Eun; Rudd, Matthew; Kim, Tae-Hwa; Oh, Ji-Yoon; Lee, Ji-Hyang; Jover, Lola; Small, Peter M.; Chung, Kian Fan; Song, Woo-Jung

doi:10.1007/s00408-023-00647-1

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article4

Preprint1

Relationship

Self Cite1

Independent4

Authors

Journals

Cited by 6 publications

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

LUNG Year in Review: 2023

Dicpinigaitis

2024

Lung

View full text Add to dashboard Cite

LUNG Year in Review: 2023

Dicpinigaitis

2024

Lung

View full text Add to dashboard Cite

Characterization of Codeine Treatment Responders Among Patients with Refractory or Unexplained Chronic Cough: A Prospective Real-World Cohort Study

Oh,

Kang,

Kang

et al. 2024

Lung

View full text Add to dashboard Cite

The Effect of Long-Term Azithromycin on Objective and Subjective Cough in Chronic Respiratory Disease: A Systematic Review and Meta-analysis of Randomised Controlled Trials and Noncomparative Studies

Sykes,

Mason,

Rahunathan

et al. 2024

Lung

View full text Add to dashboard Cite

Introduction Azithromycin is an effective treatment for various respiratory conditions but its effect on cough is poorly understood. We synthesised data from randomised controlled trials (RCTs) and noncomparative studies (NCT) examining its effect on objective and subjective cough. Methods After prospective registration on PROSPERO, we searched MEDLINE, EMBASE, and CENTRAL for both RCTs and NCT trials examining the effect azithromycin on cough in respiratory disease. Results We identified 1240 studies of which 6 (4 RCTs and 2 NCT studies) were included in the meta-analysis, with a total of 275 patients. Azithromycin was associated with significant improvement in Leicester Cough Questionnaire scores at follow-up when compared to baseline scores (SMD = 0.62 [95% CI 0.12 to 1.12], p = 0.01). However, when only RCTs were synthesised, no significant effect was observed (SMD = 0.12 [95% CI − 0.36 to 0.60], p = 0.62). There was no significant reduction in cough severity VAS score (SMD = − 0.39 [95% CI − 0.92 to 0.14], p = 0.15). There was no significant reduction in objective cough count (SMD = − 0.41 [95% CI − 1.04 to 0.32], p = 0.09). Conclusion Azithromycin therapy improves cough-related quality of life in various chronic respiratory diseases; however, there was no significant effect on cough outcomes when only data from RCTs were synthesised. We believe that to accurately identify which patients whose cough would benefit from azithromycin a large-scale clinical trial of patients with a broad spectrum of respiratory diseases, with sufficiently severe cough, should be undertaken with subgroup analysis of individual disease areas.

show abstract

Feasibility and Utility of a Smartphone Application-Based Longitudinal Cough Monitoring in Chronic Cough Patients in a Real-World Setting

Cited by 6 publications

References 35 publications

LUNG Year in Review: 2023

LUNG Year in Review: 2023

Characterization of Codeine Treatment Responders Among Patients with Refractory or Unexplained Chronic Cough: A Prospective Real-World Cohort Study

The Effect of Long-Term Azithromycin on Objective and Subjective Cough in Chronic Respiratory Disease: A Systematic Review and Meta-analysis of Randomised Controlled Trials and Noncomparative Studies

Contact Info

Product

Resources

About