“…Due to the absence of akinesia and the potential for limited patient cooperation, we suggest that (1) the two-step anesthesia method should be used in carefully selected cases and (2) the surgeon must be well experienced in vitrectomy. It has to be kept in mind that despite the perceived risk of akinesia, application of topical anesthesia alone also results in lack of akinesia but is unlikely to cause sight-threatening complications during cataract surgery [33], vitrectomy [20, 21, 27, 28, 32, 34, 35], combined phacoemulsification and vitrectomy [29], or vitrectomy-related procedures, like fluid-gas exchange for open macular hole after vitrectomy [36]. A 2-year prospective study comparing lidocaine 2% jelly versus peribulbar anesthesia for 25- and 23-gauge sutureless vitrectomy also indicated that lack of akinesia did not prevent a successful surgical result [37].…”