Feasibility and safety of triple dose platelet collection by apheresis

Abstract

Triple dose platelet collection is feasible and safe provided that donors are carefully checked for triple dose eligibility.

Additive solutions differentially affect metabolic and functional parameters of platelet concentrates

“…The study was approved by the Ethics Committee of the Medical University of Vienna. Twelve platelet donors with a body weight >60 kg (f/m: 3/9; median age 43 years, range: 26–57) were recruited from our routine multicomponent donor pool and fulfilled the requirements for triple PCs according to the European guidelines and local authorities . They were included in the study after giving written informed consent for scientific use of their donations instead of patients' support.…”

Donor safety in triple plateletpheresis: results from the German and Austrian Plateletpheresis Study Group multicenter trial

“…In Europe, the plateletpheresis‐associated PLT loss per donor is indirectly restricted by the maximum limit of 26 apheresis procedures per year and a relative low minimum number of at least 2 × 10 11 PLTs/TU 13,14 . Hence, any intensification of the procedure, either by increasing the number of PLTs, for example, to at least 4.0 × 10 11 per TU, 10,15 or by introducing TP with a minimum PLT content of at least 2.5 × 10 11 to 3.5 × 10 11 per TU, 5,9,16‐18 will inevitably lead to higher PLT losses for donors. In an attempt to establish a possible safety margin for a TP program, a single‐center observational pilot trial was performed at Hannover Medical School in 2005 and included 1132 DPs and 442 TPs 18 .…”

Recruitment of platelets, white blood cells, and hematopoietic progenitor cells during high‐yield plateletpheresis

“…The use of platelet (PLT) concentrates obtained from individual donors by automated apheresis increases steadily. New technologies have improved the efficiency and donor tolerance of plateletpheresis, providing an efficient PLT collection of up to 10 × 10 11 PLTs per donation (corresponding to 3‐4 PLT units), which also minimizes the patient exposure to multiple donors 1‐3 …”