Feasibility and Safety of Laparoscopic Right Colectomy in Oldest-Old Patients with Colon Cancer: Results of the CLIMHET Study Group

Franco, Ilaria Fabiola; de’Angelis, Nicola; Canouï‐Poitrine, Florence; Roy, Bertrand Le; Courtot, L.; Voron, Thibault; Aprodu, Razvan; Salamé, Ephrem; Saleh, Nour Bou; Berger, Anne; Ouaïssi, Mehdi; Altomare, Donato F.; Pezet, Denis; Mutter, Didier; Brunetti, Francesco; Méméo, Riccardo

doi:10.1089/lap.2018.0040

Cited by 10 publications

(6 citation statements)

References 53 publications

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“…Most people believe that older people with pneumonia or cardiopulmonary complications are not suitable for laparoscopic surgery because a pneumoperitoneum with carbon dioxide can cause adverse pathophysiological changes (such as hypercapnia), reduce venous return, and increase airway pressure [45]. However, age is not a contraindication for laparoscopic surgery [46], as demonstrated by a lower rate of pneumonia and cardiopulmonary complications, as well as quicker recovery and greater scope for self-care, compared to open surgery [47,48]. Furthermore, previous research has established that laparoscopic surgery has a protective effect on tumors in patients [49].…”

Section: Discussionmentioning

confidence: 99%

Effects of sarcopenia, hypoalbuminemia, and laparoscopic surgery on postoperative complications in elderly patients with colorectal cancer: A prospective study

Chen¹,

Huang²,

Xu³

et al. 2020

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With the increasing number of elderly patients, the risk of diseases such as colorectal cancer (CRC) has increased. The objective of this prospective study was to explore the effects of sarcopenia, hypoalbuminemia, and laparoscopic surgery on postoperative complications among elderly patients who recently underwent colorectal surgery. Patients aged over 65 years who underwent surgery for CRC at the First Affiliated Hospital of Wenzhou Medical University were considered for this study. The demographical and clinical characteristics of these patients, as well as postoperative complications, were prospectively analyzed. The patients were divided into two groups depending on the diagnosis of sarcopenia, and the clinical variables corresponding to the two groups were compared. Further, the risk factors associated with postoperative complications were evaluated using univariate analysis and multivariate logistic regression analysis. A total of 360 patients fulfilled the inclusion criteria. Incidences of postoperative complications in the sarcopenia and non-sarcopenia groups were at 38.3% and 27.3%, respectively. In addition, sarcopenia (p=0.029) and hypoalbuminemia (p=0.010) were identified as independent risk factors, while laparoscopic surgery (p=0.023) was identified as a protective factor for postoperative complications. However, laparoscopic surgery was a protective factor for postoperative complications in the colon group only (p=0.001). Sarcopenia and hypoalbuminemia are independent risk factors that influence the probability of developing complications following CRC surgery. Laparoscopic surgery is a protective factor for postoperative complications of CRC patients, particularly colon cancer patients.

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Section: Discussionmentioning

confidence: 99%

Effects of sarcopenia, hypoalbuminemia, and laparoscopic surgery on postoperative complications in elderly patients with colorectal cancer: A prospective study

Chen¹,

Huang²,

Xu³

et al. 2020

neo

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“…Among the remaining 67 articles, 57 were excluded after review of the title/abstract, based on the selection criteria and PICO criteria for this study. The remaining 10 articles were screened by full-text review, and finally, 3 studies [23][24][25] that included a total of 1,207 patients who had undergone surgery for CRC were regarded as suitable for inclusion in the data synthesis. The selection process is summarized in Fig.…”

Section: Study Identification and Eligibilitymentioning

confidence: 99%

“…Among the 3 studies, 2 studies 23,25) performed "1 versus 1" matching, and the third study 24) performed "1 versus 2" matching.…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

“…Among the 3 studies, one study 23) included patients with CRC, one study 24) included patients with colon cancer (CC), and one study 25) included patients with rectal cancer (RC).…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

“…Among the 3 studies, one study 24) defined aged patients with CC as patients who were 80 years old or over (≥80 years), one study 23) defined aged patients as those who were 75 years old or over (≥75 years), and one study 25) defined aged patients as those who were 70 years old or over (≥70 years).…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

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Influence of Age on Anastomotic Leakage in Patients with Colorectal Cancer Undergoing Surgery: A Meta-analysis Using Propensity Score Matching Analysis

Nishi,

Ishizuka,

Shibuya

et al. 2023

JJCS

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Numerous studies have been conducted to compare the incidence of anastomotic leakage between aged and non-aged patients with colorectal cancer (CRC), although the patient background factors were not aligned in most studies.Therefore, the aim of this study was to explore the influence of age on the risk of anastomotic leakage following surgery in patients with CRC.We performed a comprehensive electronic search of the literature published until March 2020 to identify propensity score matching (PSM) studies conducted to compare the incidence of anastomotic leakage between aged and non-aged patients with CRC. A meta-analysis was also performed using random-effects models to calculate the risk ratio (RR) and 95％ confidence interval (CI), and heterogeneity was analyzed using I 2 statistics.Three studies involving a total of 1207 patients who had undergone surgery for CRC were included in this meta-analysis. The rate of postoperative anastomotic leakage was 6.5％ (34/523) in the aged patient group, and 4.7％ (32/684) in the non-aged patient group. The meta-analysis revealed no significant difference in the incidence of anastomotic leakage between the two age groups (RR, 1.26; 95％ CI, 0.80-2.00; P = 0.32; I 2 = 0％).Thus, this meta-analysis revealed no significant influence of age on the risk of anastomotic leakage

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Evaluation of the safety and efficacy of perform enterectomy in colorectal cancer patients aged 80 or older. A meta-analysis and a systematic review

Chen

et al. 2023

Int J Colorectal Dis

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Feasibility and Safety of Laparoscopic Right Colectomy in Oldest-Old Patients with Colon Cancer: Results of the CLIMHET Study Group

Cited by 10 publications

References 53 publications

Effects of sarcopenia, hypoalbuminemia, and laparoscopic surgery on postoperative complications in elderly patients with colorectal cancer: A prospective study

Effects of sarcopenia, hypoalbuminemia, and laparoscopic surgery on postoperative complications in elderly patients with colorectal cancer: A prospective study

Influence of Age on Anastomotic Leakage in Patients with Colorectal Cancer Undergoing Surgery: A Meta-analysis Using Propensity Score Matching Analysis

Evaluation of the safety and efficacy of perform enterectomy in colorectal cancer patients aged 80 or older. A meta-analysis and a systematic review

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