Feasibility and response of helical tomotherapy in patients with metastatic colorectal cancer

Abstract

PurposeTo investigate the treatment outcome and the toxicity of helical tomotherapy (HT) in patients with metastatic colorectal cancer (mCRC).Materials and MethodsWe retrospectively reviewed 18 patients with 31 lesions from mCRC treated with HT between 2009 and 2013. The liver (9 lesions) and lymph nodes (9 lesions) were the most frequent sites. The planning target volume (PTV) ranged from 12 to 1,110 mL (median, 114 mL). The total doses ranged from 30 to 70 Gy in 10-30 fractions. When the α/β value for the tumor was assumed to be 10 Gy for the biologically equivalent dose (BED), the total doses ranged from 39 to 119 Gy10 (median, 55 Gy10). Nineteen lesions were treated with concurrent chemotherapy (CCRT).ResultsWith a median follow-up time of 16 months, the median overall survival for 18 patients was 33 months. Eight lesions (26%) achieved complete response. The 1- and 3-year local progression free survival (LPFS) rates for 31 lesions were 45% and 34%, respectively. On univariate analysis, significant parameters influencing LPFS rates were chemotherapy response before HT, aim of HT, CCRT, PTV, BED, and adjuvant chemotherapy. On multivariate analysis, PTV ≤113 mL and BED >48 Gy10 were associated with a statistically significant improvement in LFPS. During HT, four patients experienced grade 3 hematologic toxicities, each of whom had also received CCRT.ConclusionThe current study demonstrates the efficacy and tolerability of HT for mCRC. To define optimal RT dose according to tumor size of mCRC, further study should be needed.

Screening of radiotracer for diagnosis of colorectal cancer liver metastasis based on MACC1-SPON2

“…Once tumor cells fall off the primary tumor and enter the blood circulation, they are easily Metastases formed in the liver. If effective treatment is not available, the probability of liver metastasis will eventually be at least 50% [ 3 ]. Therefore, to explore the genes that lead to the development of CRC, and to understand the clinical significance of these genes is crucial for the diagnosis and treatment of CRC.…”

Screening of Radiotracer for Diagnosis of Colorectal Cancer Liver Metastasis Based on MACC1-SPON2

“…The main cause of death of CRC is liver metastasis. If effective treatment is not available, the probability of liver metastasis will eventually be at least 50% [4] . Therefore, to explore the genes that lead to the development of CRC, and to understand the clinical signi cance of these genes is crucial for the diagnosis and treatment of CRC.…”