Feasibility and Reliability of Functional Muscle Tests in Lung Transplant Recipients

Kienbacher, Thomas; Achim-Gunacker, Grace; Pachner, Melanie; Kerschan‐Schindl, Katharina; Gunacker, Patrik; Habenicht, Richard; Klepetko, Walter; Jaksch, Péter; Doblhammer, Stephan; Ebenbichler, Gerold

doi:10.1097/phm.0000000000000849

Cited by 8 publications

(5 citation statements)

References 29 publications

(32 reference statements)

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“…However, before this functional back muscle test can be offered as a preventive diagnostic tool, data processing would need to be further developed to a fully automatic procedure, and the absolute reliability of the IMDF-EMG fatigue slope-based variables needs to be further improved. As our novel EMG-based test is based on a sub-maximum cyclic exercise protocol at moderate load, testing can likely be considered safe even in patients at risk for increased vertebral fractures, and it is simple and quick to perform [90]. Therefore, this test would meet the basic requirements for implementation of nation-wide screening to detect early forms of deterioration in muscles that are the most likely to predispose elderly persons to future falls and fall-related injuries, frailty and early death.…”

Section: Discussionmentioning

confidence: 99%

Age-specific differences in the time-frequency representation of surface electromyographic data recorded during a submaximal cyclic back extension exercise: a promising biomarker to detect early signs of sarcopenia

Habenicht

Ebenbichler

Bonato

et al. 2020

J NeuroEngineering Rehabil

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Purpose: Motivated by the goal of developing new methods to detect early signs of sarcopenia, we investigated if surface electromyographic (SEMG) data recorded during the performance of cyclic, submaximal back extensions are marked by age-specific differences in their time and frequency characteristics. Furthermore, day-today retest reliability of the EMG measures was examined. Methods: A total of 86 healthy volunteers used a back dynamometer to perform a series of three maximal voluntary contractions (MVC) consisting of isometric back extensions, followed by an isometric back extension at 80% MVC, and finally 25 slow cyclic back extensions at 50% MVC. SEMG data was recorded bilaterally at L1, L2, and L5 from the iliocostalis lumborum, longissimus, and multifidus muscles, respectively. Tests were repeated two days and six weeks later. A linear mixed-effects model with fixed effects "age, sex, test number" and the random effect "person" was performed to investigate age-specific differences in both the initial value and the time-course (as defined by the slope of the regression line) of the root mean square (RMS-SEMG) values and instantaneous median frequency (IMDF-SEMG) values calculated separately for the shortening and lengthening phases of the exercise cycles. Generalizability Theory was used to examine reliability of the EMG measures. Results: Back extensor strength was comparable in younger and older adults. The initial value of RMS-SEMG and IMDF-SEMG as well as the RMS-SEMG time-course did not significantly differ between the two age groups. Conversely, the IMDF-SEMG time-course showed more rapid changes in younger than in older individuals. Absolute and relative reliability of the SEMG time-frequency representations were comparable in older and younger individuals with good to excellent relative reliability but variable absolute reliability levels.

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Section: Discussionmentioning

confidence: 99%

Age-specific differences in the time-frequency representation of surface electromyographic data recorded during a submaximal cyclic back extension exercise: a promising biomarker to detect early signs of sarcopenia

Habenicht

Ebenbichler

Bonato

et al. 2020

J NeuroEngineering Rehabil

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“…Maximum hand muscle grip strength (Jamar®, JLW Instruments, Chicago, IL, USA) [ 16 ], five times chair rise time (CR), standard spirometry data (MasterScreen Body, Jäger, Germany), body mass index, the European quality of life 5D (EQ-5D-3L) instrument [ 17 ] and the short form 36 test (SF-36) [ 18 ] were collected at baseline.…”

Section: Methodsmentioning

confidence: 99%

Reproducibility of the 6-minute walk test in lung transplant recipients

Ebenbichler

Muraközy

Kohlmann

et al. 2022

Wien Klin Wochenschr

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Summary Purpose There is reason to believe that the favorable measurement properties of the 6‑minute walk test (6MWT) reported for retest reliability and its capability to detect a true change in healthy individuals or persons with chronic respiratory disease may not apply to lung transplant recipients (LuTXr). We therefore investigated retest reliability of the 6MWT and, in addition, made an attempt to explore whether the 6MWT was sensitive enough to detect important changes that occur with postacute rehabilitation in LuTXr after first time LuTX. Methods Immediately before postacute rehabilitation, 50 LuTXr completed 6MWT testing twice, separated by 1–2 workdays (retest reliability), and were reassessed after completion of rehabilitation 2 months later (sensitivity to changes). Body function measures and health-related quality of life (HRQoL) assessments were collected at baseline. Results Baseline retest 6‑minute walk distance (6MWD) and the age-related predicted walking distance (6MWD%pred) scores significantly increased before postacute rehabilitation. The intraclass coefficient of correlation ICC of the 6MWD was 0.93 (95% confidence interval, CI: 0.88–0.96) and its smallest real difference (SRD) 79 m (95% CI: 52;107). Receiver operating curve analyses revealed the rehabilitation associated changes in 6MWD/6MWD%pred to exceed the SRD/SRD% values in a highly accurate way. Conclusion The 6MWT overall represents a reliable functional performance tool in LuTXr that is sensitive to detect changes in physical performance as a result of medical postacute rehabilitation.

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“…The duration of the post-acute rehabilitation period was 1–2 months and was tailored to the individual patient’s needs. As already described [15], Austrian citizens received an inpatient rehabilitation, and foreign patients for economic reasons an outpatient rehabilitation program which was similar but less intensively supervised. It included endurance, strength, and strength endurance training with elastic bands for all major muscle groups.…”

Section: Methodsmentioning

confidence: 99%

Myostatin and other musculoskeletal markers in lung transplant recipients

et al. 2018

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Recipients of lung transplantation (LuTx) may experience impaired muscle function and bone metabolism even after rehabilitation. We investigated the potential use of musculoskeletal markers in identifying the impairment of muscle function and bone function in these patients. Biochemical parameters, bodily functions, and lung function of 37 LuTx recipients were evaluated at the time of their discharge from the hospital stay and about 6 months later. The biomarkers were also assessed in 30 healthy age and gender distribution-matched controls. Compared to controls, the negative muscle regulator myostatin was elevated in LuTx recipients at baseline and follow-up, whereas its opponent follistatin only showed a group-specific difference at follow-up. LuTx recipients had reduced serum levels of sclerostin and increased levels of dickkopf 1 and periostin. Lung function and physical function were improved during follow-up. The change in lung function was correlated with the change in chair-rising time and the 6-min walking test. At follow-up, all musculoskeletal markers of LuTx recipients differed from those of controls, thus reflecting their still reduced lung function and bodily functions. Among the tested biomarkers, myostatin, sclerostin, dickkopf 1, and periostin were useful to detect impaired musculoskeletal function in LuTx recipients. Myostatin may serve as a target of treatment in the future.

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Feasibility and Reliability of Functional Muscle Tests in Lung Transplant Recipients

Abstract: Supplemental digital content is available in the text.

Cited by 8 publications

References 29 publications

Age-specific differences in the time-frequency representation of surface electromyographic data recorded during a submaximal cyclic back extension exercise: a promising biomarker to detect early signs of sarcopenia

Age-specific differences in the time-frequency representation of surface electromyographic data recorded during a submaximal cyclic back extension exercise: a promising biomarker to detect early signs of sarcopenia

Reproducibility of the 6-minute walk test in lung transplant recipients

Myostatin and other musculoskeletal markers in lung transplant recipients

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