Feasibility and parent satisfaction of a physical therapy intervention program for children with acute lymphoblastic leukemia in the first 6 months of medical treatment

Gohar, Shadi Farzin; Comito, Melanie M.; Price, Jennifer; Marchese, Victoria

doi:10.1002/pbc.22713

Cited by 55 publications

(64 citation statements)

References 31 publications

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Section: Resultsmentioning

confidence: 99%

“…Of all the study participants, 257 children were diagnosed with cancer. Six of the identified studies did not enroll a control group (19)(20)(21)(22)(23)(24)(25)(26). Ten studies did include 10 or Training: adherence (>90%); no adverse effects; aerobic fitness ALC, absolute lymphocyte count; ALL, acute lymphoblastic leukemia; ANC, absolute neutrophil count; APA, adapted physical activity; BMD, bone mineral density; CBC, complete blood count; CG, control group; DF-ROM, dorsiflexion range of motion; hRR, heart rate range; hR max , maximum heart rate; hSCT, hematopoietic stem cell transplant; IG, intervention group; IG vs. CG, comparison between cohorts; IGF, insulin-like growth factor; ITT, intention-to-treat analyses; n, sample size; NS, not significant; P, level of significance; PA, physical activity; PACER, progressive aerobic cardiovascular endurance run; PBSCT, peripheral blood stem cell transplant; PP, per-protocol analyses; QoL, quality of life; t, measuring point; TUDS, timed up and down stairs test; TUG, time up and go test; VT, ventilator threshold; WBC, white blood cells.…”

Section: Resultsmentioning

confidence: 99%

“…No adverse effects or complications related to the exercise intervention were reported in any of these 17 studies. Within four studies, "feasibility" was one of the main outcomes, and all authors present positive results within this context (20,26,32,35). Adherence has been examined within eight studies and ranges between 67 and 98% (8,21,23,24,(27)(28)(29)32,35).…”

Section: Exercise In Pediatric Oncologymentioning

confidence: 99%

“…Only two of all included studies calculated and published confidence intervals (8,31). Although eight studies were conducted with acute lymphoblastic leukemia (ALL) patients (20,(22)(23)(24)26,28,30,31,34,35), study cohorts including mixed cancer types have also been examined (19,21,25,29,33,36). The settings differ from supervised exercise intervention (8,19,(21)(22)(23)(24)27,29,32,33,35) to home-based exercise programs (31,34).…”

Section: Exercise In Pediatric Oncologymentioning

confidence: 99%

“…The settings differ from supervised exercise intervention (8,19,(21)(22)(23)(24)27,29,32,33,35) to home-based exercise programs (31,34). Six studies included a combination of a supervised and an additional home-based exercise intervention (20,25,26,28,30,36). Exercise interventions within the hospital were always supervised.…”

Section: Exercise In Pediatric Oncologymentioning

confidence: 99%

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Clinical exercise interventions in pediatric oncology: a systematic review

2013

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Studies in pediatric oncology have shown a positive effect of physical activity on disease-and treatment-related side effects. Although several reviews have approved the benefits of therapeutic exercise for adult cancer patients, no systematic review exists summarizing the evidence of physical activity in pediatric oncology. We identified a total of 17 studies using the PubMed database and Cochrane library. To evaluate the evidence, we used the evaluation system of the Oxford Center for Evidence-Based Medicine 2001. The findings confirm that clinical exercise interventions are feasible and safe, especially with acute lymphoblastic leukemia (ALL) patients and during medical treatment. No adverse effects have been reported. Positive effects were found on fatigue, strength, and quality of life. Single studies present positive effects on the immune system, body composition, sleep, activity levels, and various aspects of physical functioning. Child-specific aspects such as cognitive abilities, growth, adolescence, and reintegration into peer-groups, school, and sports have barely been taken into consideration. The evidence for exercise interventions in pediatric oncology is rated level "3. " Although the results are very promising, future research of high methodological quality and focusing on child-specific aspects is needed to establish evidence-based exercise recommendations, particularly for childhood cancer patients.A s a result of improved treatment regimes in pediatric oncology, the survival rates of children with cancer have risen to ~80% for 5-y survival (1-4). Therefore, the population of childhood cancer survivors is constantly growing. Despite these positive developments, childhood cancer is associated with a wide spectrum of various disease-and treatment-related side effects that may develop into chronic diseases and therefore result in long-term consequences. A negative impact on social, psychological, and physiological levels can be observed. Inactivity (5-7), impaired cardiopulmonary and musculoskeletal function, as well as reduced motor performance levels (8,9) and cognitive abilities (10) have been detected. Current studies also examined a negative impact on psychological well-being, satisfaction, and social functioning (11). Taken together, an impaired quality of life can thus be determined (8,12).During the past few years, several studies have generated first hints describing holistic, positive effects of clinical exercise interventions in pediatric oncology. First results present an association between increased physical activity levels in childhood cancer patients and an improvement in quality of life (13). In particular, physical functioning is increased, anxiety is reduced, and social integration is encouraged (14). Considering the fact that physical activity plays a vital role in the physiological and psychosocial development of children, therapeutic exercise in pediatric oncology is particularly important. However, there is still a lack of comprehensive and evidence-based data in the field o...

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