Feasibility and Outcomes of an Exercise Intervention for Chemotherapy-Induced Heart Failure

Abstract

Purpose: Cancer treatment-related heart failure (HF) is an emerging health concern, as the number of survivors is increasing rapidly, and cardiac health issues are a leading cause of mortality in this population. While there is general evidence for the efficacy of exercise rehabilitation interventions, more research is needed on exercise rehabilitation interventions for patients specifically with treatment-induced HF, and if such interventions are safe and wellaccepted. This study provides feasibility and health outcomes of a pilot exercise intervention for cancer survivors with chemotherapy-induced HF. Methods: Twenty-five participants were randomized to a clinic-based exercise intervention or a wait-list control group, or alternatively allowed to enroll in a home-based exercise intervention if they declined the randomized study. For purposes of analysis, both types of exercise programs

Strategy of implementing aerobic exercise as a pleiotropic effect in cancer patients with a history of administration cardiotoxic agents: a systematic review

“…The Framingham risk score is a scoring system developed by the Canadian Cardiovascular Society which is used to predict the incidence of cardiovascular disease for the next 10 years. 25 Similar results were also obtained from RCT research conducted by Zhijun Ma in 2018 on 70 women with breast cancer after surgery for anthracycline chemotherapy recipients who were given the intervention of aerobic exercise for 50 minutes within 16 weeks to increase VO2 max and LVEF and to some extent, it could reverse the damage of chemotherapy drugs to the heart. 26 Based on the results of these studies, exercise was carried out 3 times per week for 30-50 minutes in 16 weeks has been shown to increase VO2 max and LVEF, so that it can maintain cardiovascular function and prevent cardiotoxic effects from Chemotherapy.…”

Feasibility of procedures for a randomised pilot study of reduced exertion, high-intensity interval training (REHIT) with non-diabetic hyperglycaemia patients

“…It was not possible, based on the data collected, to estimate variability for use in a formal sample size calculation for a future study and reinforces the need to answer questions relating to whether a study can be done in terms of estimating the rate of eligible people who are willing to participate [54]. Similar feasibility studies have highlighted that physical activity interventions can be challenging and resource-intensive with recruitment, retention, and participant dropout issues prevalent [47,[55][56][57]. As such, advancing to a large-scale study is not appropriate with the study in its current form because key progression criteria were not met.…”

Cardio-Oncology Rehabilitation (CORE) Exercise Prescription and Programming

“…Recently, high-intensity aerobic interval training (HIIT) has been shown to be safe and beneficial for patients with cancer during chemotherapy for breast cancer. 11,12 A 2019 American Heart Association scientific statement, endorsed by the American Cancer Society, provided a rationale for partnering with existing multidimensional, interdisciplinary outpatient CR programs to provide supervised exercise training and risk factor control services for cancer survivors. 10 This concept was introduced in 2015 by Dittus and colleagues 13 at The University of Vermont.…”

“…The principles of exercise prescription for cancer survivors are similar to those used for clinical populations typically referred to CR. Recently, high-intensity aerobic interval training (HIIT) has been shown to be safe and beneficial for patients with cancer during chemotherapy for breast cancer 11,12…”