Feasibility and Initial Effectiveness of Home Exercise During Maintenance Therapy for Childhood Acute Lymphoblastic Leukemia

Esbenshade, Adam J.; Friedman, Debra L.; Smith, Webb A.; Jeha, Sima; Pui, Ching Hon; Robison, Leslie L.; Ness, Kirsten K.

doi:10.1097/pep.0000000000000053

Cited by 49 publications

(57 citation statements)

References 50 publications

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“…For instance, Boman et al [40], in a study of 528 adult survivors of childhood central nervous system (CNS) tumors, indicated that both perceived global health and functional abilities are important indicators of self-confidence for participation in sport/physical activity. Also, an exercise intervention delivered at home among twelve children (aged 5–10 years) with acute lymphoblastic leukemia, with a remote exercise coach who contacted them weekly during the maintenance phase of chemotherapy, had excellent adherence (82% of prescribed session) and demonstrated improved fitness outcomes [41]. This intervention was tailored to each child’s current abilities and modified accordingly to allow the child to be successful throughout the course of the intervention and to improve self-confidence.…”

Section: Potential Interventions For Fitness and Quality Of Life In Cmentioning

confidence: 99%

Frailty and quality of life in adult survivors of childhood cancer

Ness

Howell

Bjornard

2017

Expert Review of Quality of Life in Cancer Care

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Introduction Adult survivors of childhood cancer are at risk for frailty, a state of diminished physiologic reserve, typically seen in older adults, associated with morbidity and mortality. They are also at risk for poor quality of life. This review explores potential associations between frailty and quality of life and proposes potential interventions that may prevent or remediate frail health. Areas covered and literature search A literature search using MEDLINE and EMBASE was undertaken using key words: childhood cancer survivors and each of the following: frailty, physical performance, emotional health, and quality of life. 796 abstracts were reviewed for relevance. Reference lists for retrieved articles were consulted for pertinent manuscripts (N=40). Recent literature (from January 2013 to November 2016) was obtained using the key words: aging and frailty and quality of life. The final reference list includes 44 documents. Expert opinion Childhood cancer survivors are at risk for frailty and less than optimal quality of life. Poor emotional health may contribute to this association. Further research is needed to better explain these associations and to provide a foundation for the development of interventions designed to prevent and remediate frail health and suboptimal quality of life in this population.

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Section: Potential Interventions For Fitness and Quality Of Life In Cmentioning

confidence: 99%

Frailty and quality of life in adult survivors of childhood cancer

Ness

Howell

Bjornard

2017

Expert Review of Quality of Life in Cancer Care

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“…Some previous reports showed that physical therapy is efective in pediatric leukemia patients [95,96]. Additionally, some previous reports showed that physical therapy is efective in patients with HSCT [90,97].…”

Section: Physical Therapymentioning

confidence: 99%

Physical Therapy in Patients with Cancer

Morishita¹,

Tsubaki²

2017

Clinical Physical Therapy

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Physical therapists often treat cancer patients. Cancer treatment includes chemotherapy, radiotherapy, and surgery, which are being continuously developed and thus increase survival of patients with each cancer diagnosis. More speciically, 5-year survival rates increase with each cancer diagnosis. Cancer patients have many problems including muscle weakness, pulmonary dysfunction, fatigue, and pain. In the end, patients with cancer tend to have a decline in activities of daily living (ADL) and quality of life (QOL). Additionally, cancer patients often have progressive disease, depression, and anxiety. Physical therapy often helps patients regain strength and physical function and improve their QOL and independence of daily living that they may have lost due to cancer or its treatment. Physical therapy has an important role in increasing physical function of cancer patients, cancer survivors, and children with cancer. In the future, physical therapy may be progressively needed for management of cancer patients.

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“…As a result of the numerous LAE related to pediatric cancer treatment, an interest in using exercise as a therapeutic measure to attenuate or reverse many cancer-related LAE in the pediatric population has surfaced. While comparatively less studied, the research suggests that there is a positive effect of physical activity on organ system function, fatigue, and physical well-being in children during and after cancer treatment [39][40][41][42][43][44][45][46][47][48][49]. It is clear that children who exercise can increase aerobic fitness and strength, with the latter a result of neuromuscular adaptations rather than skeletal muscle hypertrophy.…”

Section: Introductionmentioning

confidence: 99%

The Role of Exercise in Pediatric and Adolescent Cancers: A Review of Assessments and Suggestions for Clinical Implementation

Klika

Tamburini

Galanti

et al. 2018

JFMK

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Abstract:In the European Union, five-year survival rates for childhood cancer patients are approaching 72-80%, which is a testament to better diagnostics and improved treatment. As a result, a large proportion of childhood cancer patients go on to live productive lives well past reproductive age. While this is encouraging, childhood cancer treatment is accompanied by multiple long-term adverse effects on physical and mental wellbeing. While there are several approaches to address mental health, reproductive integrity, secondary pathologies, and recurrence, in order to optimize quality of life in childhood cancer patients, exercise and nutrition should also be considered. It is clear that physical activity plays an important role in the prevention and reduction of long-term adverse side effects associated with cancer treatment in both children and adults. However, the current exercise guidelines for cancer survivors are based on adult data and accordingly are not appropriate for children. As children and adults are markedly different, including both the pathophysiology of cancer and exercise response, treatment plans incorporating exercise for children should be age-specific and individually tailored to both reduce the development of future comorbidities and enhance physical health. The purpose of this paper is to review the predominant cancer types and effects of cancer treatment in children, describe several special considerations, and propose a framework for assessment and exercise guidelines for this population.

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Feasibility and Initial Effectiveness of Home Exercise During Maintenance Therapy for Childhood Acute Lymphoblastic Leukemia

Cited by 49 publications

References 50 publications

Frailty and quality of life in adult survivors of childhood cancer

Frailty and quality of life in adult survivors of childhood cancer

Physical Therapy in Patients with Cancer

The Role of Exercise in Pediatric and Adolescent Cancers: A Review of Assessments and Suggestions for Clinical Implementation

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