Feasibility and effects on the gut microbiota of a 12-week high-intensity interval training plus lifestyle education intervention on inactive adults with celiac disease

Abstract

This study assessed the feasibility and benefits of high intensity interval training (HIIT) plus lifestyle education among inactive adults with celiac disease. 41 participants were randomized to receive the intervention (HIIT+) for 12-weeks or waitlist control (WLC). Testing was completed at baseline, immediately post- and 3-months post-intervention. Generalized estimating equations were used to assess changes in the outcome variables over time between the groups. Mean percent of age-predicted maximum heart rate was 97.9% and average rating of perceived exertion (RPE) was 6.33 (out of 10) during HIIT intervals. Following the intervention, the HIIT+ group showed enrichment in relative abundance of Parabacteroides and Defluviitaleaceae_UCG¬_011 while WLC showed enrichment in relative abundance of Roseburia intestinalis, Klebsiella and Adlercreutzia. A unique set of taxa were differentially abundant between the groups at 3-months post-intervention. HIIT+ participants experienced a reduction in resting heart rate (-6.6 bpm) immediately post-intervention compared to WLC. Further research is needed to establish an optimal HIIT protocol that may improve VO2max and metabolic syndrome biomarkers. Findings from this pilot study provide preliminary evidence that a HIIT+ intervention is feasible for inactive adults with celiac disease and leads to favourable changes in resting HR alongside potentially beneficial shifts in gut microbiota. Trial registration number: ClinicalTrials.gov number NCT03520244 
 
 Novelty
 • High intensity interval training leads to potentially beneficial changes in the gut microbiota of adults with celiac disease.
 • A high intensity interval training exercise intervention is feasible and well tolerated for patients with celiac disease.

Accumulation of Black Carbon Particles in Placenta, Cord Blood, and Childhood Urine in Association with the Intestinal Microbiome Diversity and Composition in Four- to Six-Year-Old Children in the ENVIR ON AGE Birth Cohort

“…Additionally, 41 inactive adults with celiac disease showed enriched intestinal Defluviitaleaceae levels accompanied by a reduction in resting heart rate after a 12-wk intervention with high-intensity interval training and lifestyle education. 67 Furthermore, the bacterial family Marinifilaceae was negatively associated with black carbon particles in placental tissue in this study. Marinifilaceae has been indicated as a key actor in gut health by Ge et al.…”

Synergistic effects of exercise and catalase overexpression on gut microbiome

“…Previous studies have indicated possible beneficial effects of Parabacteroides . For example, Parabacteroides became abundant in another study after 12‐week of high‐intensity interval training in patients with celiac disease (Warbeck et al ., 2020) and with exercise intervention in male Wistar rats on high‐fat diet (Carbajo‐Pescador et al ., 2019). Parabacteroides has also been positively correlated with beneficial metabolites and weight loss in a rat model and negatively correlated with both body weight and leptin in the same model, suggesting it could have a protective effect against obesity (Carbajo‐Pescador et al ., 2019).…”

The Effect of Exercise Prescription on the Human Gut Microbiota and Comparison between Clinical and Apparently Healthy Populations: A Systematic Review

“…Sixteen studies included participants from clinical populations. Of these, three studies compared data to an apparently healthy population [ 33 , 34 , 36 ], with the rest comparing exercise groups [ 35 , 40 , 41 ], waitlist or crossover [ 37 , 38 , 39 , 42 ], control groups [ 43 , 44 , 45 ] or did not include a comparison [ 30 , 31 , 32 ]. Of the remaining 12 ‘healthy population’ studies, four included apparently healthy sedentary and recreationally active participants [ 20 , 27 , 28 , 29 ]; one study was in a military setting [ 21 ], and seven studies assessed athletes only [ 18 , 19 , 22 , 23 , 24 , 25 , 26 ].…”

“…Most clinical populations were characterised by metabolic disorders ( n = 11, 60% of clinical studies) [ 30 , 31 , 32 , 34 , 36 , 37 , 38 , 40 , 41 , 43 , 44 ]. Other clinical population domains included neurological disorder ( n = 1, 6%) [ 45 ], autoimmune ( n = 1, 6%) [ 42 ], inflammatory bowel disease ( n = 1, 6%) [ 39 ], myalgic encephalomyelitis/chronic fatigue syndrome ( n = 1, 6%) [ 33 ] and elderly populations ( n = 1, 6%) [ 35 ].…”