Feasibility and Effectiveness of a Defined-Formula Diet Regimen in Treating Active Crohn's Disease

Malchow, H; Steinhardt, H. J.; Lorenz-Meyer, H; Strohm, W. D.; Rasmussen, Steen; Sommer, H; Jarnum, S.; Brandes, J W; Leonhardt, H; K, Ewe; Jesdinsky, H. J.

doi:10.1080/00365521.1990.12067097

Cited by 122 publications

(53 citation statements)

References 21 publications

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“…Our literature search identified a total of 13 controlled clinical trials comparing DFDs with steroids (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14). Six trials did not meet the inclusion criteria of our meta-analysis for the following reasons: 1) The study by Okada et al (12) was not based on a randomized design; 2) The studies by (14); to avoid duplicate analysis of the same patient series, the Hunt study was not included.…”

Section: Literature Searchmentioning

confidence: 95%

“…In the treatment of active Crohn's disease, defined-formula diets (DFDs) have been proposed as an alternative to standard treatment with steroids (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14). Whereas the effectiveness of steroids is well established (l), the role of DFDs remains controversial because the controlled clinical trials comparing DFDs with steroids have given conflicting results (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14).…”

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confidence: 99%

“…Whereas the effectiveness of steroids is well established (l), the role of DFDs remains controversial because the controlled clinical trials comparing DFDs with steroids have given conflicting results (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14).…”

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confidence: 99%

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Defined-Formula Diets versus Steroids in the Treatment of Active Crohn's Disease A Meta-Analysis

Messori

Trallori

d’Albasio

et al. 1996

Scandinavian Journal of Gastroenterology

154

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Section: Literature Searchmentioning

confidence: 95%

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confidence: 99%

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Defined-Formula Diets versus Steroids in the Treatment of Active Crohn's Disease A Meta-Analysis

Messori

Trallori

d’Albasio

et al. 1996

Scandinavian Journal of Gastroenterology

154

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“…Such an approach may involve the administration of an enteral formula provided exclusively (EEN). Although reports vary with regard to the efficacy of EEN in adults [11][12][13][14], there is support for EEN as a treatment modality in children with efficacy equivalent to steroids in the induction of remission in active CD, while avoiding steroid-related side effects [9,10]. In addition, EEN offers nutritional and linear growth benefits [10,15].…”

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confidence: 96%

Polymeric Formula Has Direct Anti-Inflammatory Effects on Enterocytes in an in VitroModel of Intestinal Inflammation

2007

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Exclusive enteral nutrition using polymeric formula (PF) is a well-established therapeutic option for active Crohn's disease; however, its mechanisms of action are unknown. We investigated the anti-inflammatory effects of PF in an in vitro model of epithelial cell inflammation. PF did not affect cell viability over a range of dilutions, but when PF was added to the culture medium the interleukin (IL)-8 response to proinflammatory stimuli was significantly reduced. This effect was due to PF acting directly on the cells as the IL-8 response was still reduced when PF was separated from the proinflammatory stimuli in a 2-compartment system. In the presence of PF, nuclear factor (NF)-kappaB nuclear migration was not inhibited; however, IkappaBalpha degradation was delayed. PF has direct anti-inflammatory effects upon immortalized colonic enterocytes. Therefore PF may, in part, modulate gut inflammation by directly reducing the inflammatory response of the intestinal epithelium.

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“…So ist vor allem die Lokalisation des Befalls yon Wichtigkeit. Patienten mit Dfinndarmbefall k6nnen erfolgreich mit der EN behandelt werden, wfihrend Patienten mit ausschlieBlichem Kolonbefall schlecht auf die D~it ansprechen [36,44]. Bei Beteiligung des Dfinn-und Dickdarms ist die medikament6se Behandlung der Ern/ihrungstherapie iiberlegen.…”

Section: Enterale Erniihrungsmethodenunclassified

Welche Rolle spielt die Ern�hrung beim Morbus Crohn? Ein Beitrag zur Bedeutung der di�tetischen Therapie der Enteritis regionalis

Nagel

Canzler

Pichlmayr³

1991

Langenbecks Arch Chir

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The clinical appearance of Crohn's disease (CD) is especially marked by nutritional deficits and insufficiencies. For a long time the goal of nutritional care was reduced to the readjustment of the nutritional status. The development and clinical use of controlled parenteral nutrition (TPN) and enteral nutritive solutions (EN) did not only emphasize this therapeutical issue, but furthermore showed positive effects on the conservative as well as on the surgical treatment concepts. Therefore today artificial nutritional support is a firm part of therapy in acute, active phases or in the contact of surgical management of CD. This is especially valid in children, where complications in general and growth failure in particular can be reduced. EN is the preferred feeding method in most of the cases, due to a lower complication rate and reduced cost when compared to TPN. The question regarding the importance of nutritional support as primary therapy has also been investigated. The results differ extensively, but point towards the conclusion that patients with solitary small bowel disease do profit from this therapeutical concept. Nevertheless it is unclear, how TPN or EN interfere in the pathophysiology or -biochemistry in this process. A question about reduction e.g. of allergic components of daily diet did stimulate new theories regarding the hypothesis of a possible causal relationship between diet and the pathogenesis of CD. Investigations on dietary habits and daily dietary therapy did not reveal an overall accepted dietary guideline. Nevertheless it seems obvious that dietary counselling has a positive effect on the disease process. It does appear, that today in the acute, active phase as well as in the long term management of Crohn's disease nutritional-care is an important therapeutical method.

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Feasibility and Effectiveness of a Defined-Formula Diet Regimen in Treating Active Crohn's Disease

Cited by 122 publications

References 21 publications

Defined-Formula Diets versus Steroids in the Treatment of Active Crohn's Disease A Meta-Analysis

Defined-Formula Diets versus Steroids in the Treatment of Active Crohn's Disease A Meta-Analysis

Polymeric Formula Has Direct Anti-Inflammatory Effects on Enterocytes in an in VitroModel of Intestinal Inflammation

Welche Rolle spielt die Ern�hrung beim Morbus Crohn? Ein Beitrag zur Bedeutung der di�tetischen Therapie der Enteritis regionalis

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