Feasibility and Diagnostic Accuracy of Supersonic Shear-Wave Elastography for the Assessment of Liver Stiffness and Liver Fibrosis in Children: A Pilot Study of 96 Patients

Franchi‐Abella, Stéphanie; Corno, Lucie; Gonzalès, Emmanuel; Antoni, Guillemette; Fabrè, Monique; Ducot, B.; Pariente, D.; Gennisson, Jean‐Luc; Tanter, Mickaël; Corréas, Jean-Michel

doi:10.1148/radiol.2015142815

Cited by 120 publications

(115 citation statements)

References 24 publications

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“…However, another study didn't find any significant difference between different age groups (p = 0.11) [25] and only a trend to an increase of LSMs with age was found when using the linear transducer (p = 0.05). Technical factors may also affect LSMs, including the transducer used: a significant difference was found for mean elasticity between the linear and convex transducers: 5.96 kPa ± 1.31 and 6.94 kPa ± 1.42, respectively (p = 0.006) [25].…”

Section: Liver Stiffness Estimates In Healthy Controlsmentioning

confidence: 88%

“…LSMs were found to correlate with children's age (r = 0.429, p = 0.006), and to be significantly higher (6.1 ± 1.1 kPa) in babies older than 60 days (n = 10) than in babies of 60 days or below (5.3 ± 1.0 kPa) (n = 30) (p = 0.026) [73]. However, another study didn't find any significant difference between different age groups (p = 0.11) [25] and only a trend to an increase of LSMs with age was found when using the linear transducer (p = 0.05). Technical factors may also affect LSMs, including the transducer used: a significant difference was found for mean elasticity between the linear and convex transducers: 5.96 kPa ± 1.31 and 6.94 kPa ± 1.42, respectively (p = 0.006) [25].…”

Section: Liver Stiffness Estimates In Healthy Controlsmentioning

confidence: 91%

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Current Knowledge in Ultrasound-Based Liver Elastography of Pediatric Patients

et al. 2018

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Featured Application: In this review we present and discuss the published literature on the use of ultrasound-based liver elastography in children. The published data show that all the available shear wave elastography techniques are feasible and accurate for the assessment of liver fibrosis in children with diffuse liver disease due to several etiologies. For the assessment of focal liver lesions evidences are limited and no conclusion can be drawn so far.Abstract: Studies performed using transient elastography (TE), point shear wave elastography (pSWE) and two-dimensional shear wave elastography (2D-SWE) have shown that these techniques are all feasible and accurate in children for the evaluation of liver fibrosis due to several etiologies. However, for some specific pediatric pathologies, such as biliary atresia, the evidence is still limited. As shown in adults, inflammation is a confounding factor when assessing fibrosis severity and care should be taken when interpreting the results. Due to the scarce comparative data between serological tests and elastography techniques in children, a definite conclusion regarding which is the best cannot be drawn. Neither non-invasive elastographic techniques nor laboratory scores allow determination of the presence and the degree of inflammation, necrosis, iron or copper deposits.

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Section: Liver Stiffness Estimates In Healthy Controlsmentioning

confidence: 88%

Section: Liver Stiffness Estimates In Healthy Controlsmentioning

confidence: 91%

Current Knowledge in Ultrasound-Based Liver Elastography of Pediatric Patients

et al. 2018

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“…Additionally, apnea might not be obtained in young children. In this regard, Franchi et al's recent results showed that SWE liver measurements in children under FB conditions were feasible and accurate [11].…”

Section: Discussionmentioning

confidence: 99%

Does motion affect liver stiffness estimates in shear wave elastography? Phantom and clinical study

Pellot‐Barakat

Chami

Corréas

et al. 2016

European Journal of Radiology

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International audienceThis study was undertaken to evaluate the impact of free-breathing (FB) vs. Apnea on Shear-wave elastography (SWE) measurements.Quantitative liver-stiffness measurements were obtained during FB and Apnea for 97 patients with various body-morphologies and liver textures. Quality indexes of FB and Apnea elasticity maps (percentage of non-filling (PNF), temporal (TV) and spatial (SV) variabilities) were computed. SWE measurements were also obtained from an homogeneous phantom at rest and during a mechanically-induced motion.Liver-stiffness values estimated from FB and Apnea acquisitions were correlated, particularly for homogeneous livers (r = 0.76, P < 0.001) and favorable body-morphologies (r = 0.68, P < 0.001). However FB values were consistently 20–25% lower than Apnea ones (P < 0.001). FB also systematically resulted in degradation of TV (P < 0.005) and PNF (P < 0.001) compared to Apnea but had no impact on SV. With the phantom, no differences between SWE measurements at rest and during motion were observed.Apnea and FB measurements are highly correlated, although FB data quality is degraded compared to Apnea and estimated stiffness in FB is systematically lower than in Apnea. These discrepancies between rest and motion states were observed for patients but not for phantom data, suggesting that patient breath-holding impacts liver stiffness

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“…Elastography, mainly consisting of shear-wave elastography and strain elastography, is reported to be useful for the noninvasive diagnosis of hepatic fibrosis by measuring liver stiffness and has become a hot research topic in recent years [12,13,14,15,16,17,18]. Transient elastography (TE), a shear-wave elastography, is now accepted as a noninvasive and validated method for the detection of significant fibrosis and cirrhosis, a role that has been confirmed by considerable scientific evidence [19,20,21,22].…”

Section: Introductionmentioning

confidence: 99%

Comparison of Two-Dimensional Shear Wave Elastography and Real-Time Tissue Elastography for Assessing Liver Fibrosis in Chronic Hepatitis B

Wu¹,

Wang²,

Zhang³

et al. 2016

Dig Dis

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Background: Noninvasive assessment of liver fibrosis has important clinical significance. Different techniques including two-dimensional shear-wave elastography (2D SWE) and real-time tissue elastography (RTE) are reported to be useful for the noninvasive diagnosis of hepatic fibrosis. All these techniques are affected by many factors. How to choose a reasonable method needs further studies. Purpose: This study was conducted to comparatively assess the diagnostic performance of 2D SWE and RTE in patients with Chronic Hepatitis B (CHB) and influence of inflammation on the stiffness values obtained by both techniques, so as to objectively assess the reasonable choice between these 2 elastography techniques for noninvasive assessment of hepatic fibrosis in clinical practice. Materials and Methods: Four-hundred and thirty-seven patients with CHB meeting the inclusion criteria were enrolled in the study. All patients underwent liver stiffness measurements by using 2D SWE and RTE on the same day. Histologic fibrosis was staged and inflammation activity was graded based on the METAVIR scoring system on liver biopsy specimens. Results: The liver stiffness values by using 2D SWE and RTE both increased in parallel with the degree of liver fibrosis and the grade of inflammation. However, the diagnostic efficacy of significant fibrosis and cirrhosis using 2D SWE was significantly higher than that of RTE. The 2D SWE measurement values were statistically different in different alanine aminotransferase (ALT) levels and METAVIR activity grades; however, no statistically significant differences were observed by using RTE. The diagnostic efficacy of 2D SWE significantly varied with elevated ALT levels compared with RTE. Conclusion: 2D SWE was more accurate than RTE in the assessment of significant fibrosis and cirrhosis in patients with CHB. Compared with RTE, the measurement values and diagnostic performance obtained by 2D SWE were prone to be more easily affected by the inflammation fluctuations.

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Feasibility and Diagnostic Accuracy of Supersonic Shear-Wave Elastography for the Assessment of Liver Stiffness and Liver Fibrosis in Children: A Pilot Study of 96 Patients

Abstract: SSWE allows accurate assessment of liver fibrosis, even in children with early stage (F1-F2) disease, and the choice of transducer influences liver stiffness values.

Cited by 120 publications

References 24 publications

Current Knowledge in Ultrasound-Based Liver Elastography of Pediatric Patients

Current Knowledge in Ultrasound-Based Liver Elastography of Pediatric Patients

Does motion affect liver stiffness estimates in shear wave elastography? Phantom and clinical study

Comparison of Two-Dimensional Shear Wave Elastography and Real-Time Tissue Elastography for Assessing Liver Fibrosis in Chronic Hepatitis B

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