Abstract:Despite the large prevalence of diseases affecting cartilage (with knee osteoarthritis affecting 16% of population globally), no curative treatments are available because of the limited capacity of drugs to localise in such tissues caused by the low vascularisation and electrostatic repulsion. While an effective delivery system is sought, the only option is using high drug doses that can lead to systemic side effects. We introduced poly beta amino esters (PBAEs) polymers to effectively deliver drugs into carti… Show more
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