Feasibility and Accuracy of Different Techniques of Two-Dimensional Speckle Based Strain and Validation With Harmonic Phase Magnetic Resonance Imaging

Bansal, Manish; Cho, Goo-Yeong; Chan, Jonathan; Leano, Rodel; Haluska, Brian; Marwick, Thomas H.

doi:10.1016/j.echo.2008.09.021

Cited by 174 publications

(116 citation statements)

References 24 publications

(18 reference statements)

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“…The validation results have a close agreement with results of previous studies, which assessed peak systolic strain in normal subject using TMRI [33][34][35][36]. The concept of assessment of myocardial viability based on the analysis of function has been proven in many previous studies to allow reliable evaluation of the extent of myocardial infarction in ischemic cardiomyopathy [2,[37][38][39][40][41]. As a threshold of 50% hyper-enhancement was reported in previous studies to regain functional recovery [5,15,42,43], this cutoff value was chosen to differentiate between non-transmural and transmural infarcted tissue.…”

Section: Accepted Manuscriptsupporting

confidence: 79%

Myocardial strain assessment by cine cardiac magnetic resonance imaging using non-rigid registration

Tsadok

Friedman

Haluska

et al. 2016

Magnetic Resonance Imaging

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AimsTo evaluate a novel post-processing method for assessment of longitudinal mid-myocardial strain in standard cine cardiac magnetic resonance (CMR) imaging sequences. Methods and resultsCine CMR and tagged cardiac magnetic resonance imaging (TMRI) were performed in 15 patients with acute myocardial infarction (AMI) and 15 healthy volunteers served as control group. A second group of 37 post-AMI patients underwent both cine CMR and late gadolinium enhancement (LGE) CMR exams. Speckle tracking echocardiography (STE) was performed in 36 of these patients. Cine CMR, TMRI and STE were analyzed to obtain longitudinal strain. LGE-CMR datasets were analyzed to evaluate scar extent. Comparison of peak systolic strain (PSS) measured from CMR and TMRI yielded a strong correlation (r=0.86, p<0.001). PSS measured from CMR and STE correlated well (r=0.75, p<0.001). A cutoff longitudinal PSS value of -13.14% differentiated non-infarction from any infarcted myocardium, with a sensitivity of 93% and a specificity of 89% (area under curve (AUC) 0.95). PSS value of -9.39% differentiated non-transmural from transmural infarcted myocardium, with a sensitivity of 75% and a specificity of 67% (AUC 0.78). ConclusionThe present study showed a novel off-line post-processing method for segmental longitudinal strain analysis in mid-myocardium layer based on cine CMR data. The method was found to be highly correlated with strain measurements obtained by TMRI and STE. This tool allows accurate discrimination between different transmurality states of myocardial infarction.

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Section: Accepted Manuscriptsupporting

confidence: 79%

Myocardial strain assessment by cine cardiac magnetic resonance imaging using non-rigid registration

Tsadok

Friedman

Haluska

et al. 2016

Magnetic Resonance Imaging

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“…Overall good correlations were found for longitudinal and radial strain in healthy volunteers and in patients with ischemic heart disease [12][13][14][15] . Circumferential strain was considered by the team of Brisbane [14,15] , providing a modest correlation coefficient between both methods, between 0.51 and 0.64. However, only overall results of strain were compared in these studies, without focusing on regional analysis.…”

Section: Previously Reported Data About Regional Ecc Obtained By Mr-tmentioning

confidence: 75%

“…For example, despite a good correlation coefficient (r=0.87), it should be noticed that in the study of Amundsen et al [13] as well as in the study of Cho et al [14] , Bland-Altmann 95% limits of agreement between STE and tagging was in the range ±10%, which is almost half of the mean magnitude of circumferential strain (mean value in the range -20%). In the study of Bansal et al [15] r was 0.63 and the 95% limits of agreement was somewhat better, in the range ±6% (i.e. approximately the third of the mean circumferential strain, which is also a relatively wide spread of values).…”

Section: Previously Reported Data About Regional Ecc Obtained By Mr-tmentioning

confidence: 99%

Discrepancy between regional left ventricular regional circumferential strain assessed by MR-tagging and by speckle tracking echocardiography

Ghannudi¹,

Germain

Jeung³

et al. 2013

JBGC

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Background: In recent years, myocardial strain imaging has gained an important place for the evaluation of cardiac patients. Global longitudinal strain assessed by speckle tracking echocardiography (STE) is now commonly used but circumferential strain remains less extensively studied. MR-tagging is recognized as the reference method for circumferential strain analysis, however no validation study between regional MR-tagging and regional STE has been performed up to now. Objective:To compare segmental circumferential strain values (Ecc) obtained by speckle tracking and by MR-tagging in patient with normal systolic function in order to define if both methods are interchangeable or not.Patients and methods: patients without significant regional nor global systolic dysfunction (LVEF > 55%) were studied by MR-tagging (n=82) and by STE (n=35). Left ventricular mid-level short axis slice was obtained by both methods and paired data were available in 16 patients. Segmental Ecc values were computed in six equidistant sectors using GE EchoPac software for STE and InTag post processing software for MR-tagging. Results: 1) Comparison between regions:Overall results showed that regional peak Ecc magnitude |Eccpeak| was not uniform with both methods but in an opposite way. MR-tagging demonstrated significantly lower septal |Eccpeak| as compared with postero-lateral |Eccpeak| (-16.5±3.6 vs -23.4±4.4, p<10 -4 ). Conversely, STE showed significantly higher septal |Eccpeak| as compared with postero-lateral |Eccpeak| (-22.3±6.4 vs -13.9±6.2, p<10 -4 ). 2) Comparison between both methods: In the subgroup of patients studied by both methods, septal |Eccpeak| was 29% lower by MR-tagging as compared with STE (-14.9±2.4 vs -20.9±6.5, p<.006) and postero-lateral |Eccpeak| was 39% lower by STE as compared with MR-tagging (-12.9±5.9 vs -21.0±2.9, p<.0003). 3) Intra and interobserver coefficients of variation were homogeneous (in the range 10%-14%) for all sectors with MR-tagging but were dramatically variable with STE (15% to 20% in the anterior-septal region but three times higher, in the range 35%-40%, in the postero-lateral territory). Conclusion:Regional distributions of Ecc is not uniform but opposite results are provided by MR-tagging and by STE. This finding demonstrates that both methods cannot be considered as interchangeable. These conflicting results raise the www.sciedu.ca/jbgc Journal of Biomedical Graphics and Computing, 2013, Vol. 3, No. 4 ISSN 1925-4008 E-ISSN 1925 76 question of the validity of either MR tagging or speckle tracking for the quantification of regional circumferential strain. Some arguments, developed in the discussion would rather let believe that MR-tagging results should be more reliable.

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“…However, it has limited reproducibility and loss of speckles due to motion outside the imaging plane. 43 According to Hooke's law (i.e., forces and deformation are linked to elasticity 44 ), myocardial deformation is mainly influenced by intrinsic contractility (active forces), cavity pressures, geometry and neighboring segment interaction (passive forces or wall stress), and tissue elasticity (fiber structure and fibrosis), of which contractility is the most important. 45 In healthy animals, Jamal et al 46 showed by TDI that longitudinal strain and strain rate provided complementary information in which strain is a reflection of stroke volume and strain rate is a reflection of load-independent contractility.…”

Section: Regional Rv Function and Strainmentioning

confidence: 99%

State of the Art: Advanced Imaging of the Right Ventricle and Pulmonary Circulation in Humans (2013 Grover Conference Series)

et al. 2014

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Pulmonary arterial hypertension (PAH) is a progressive disease characterized by remodeling and vasoconstriction of the pulmonary vasculature, ultimately leading to right ventricular (RV) failure and death. Recent developments in echocardiography, cardiovascular magnetic resonance imaging, computed tomography, and positron emission tomography allow advanced, noninvasive, in vivo assessment of the RV and have contributed to the identification of risk factors, prognostic factors, and monitoring of therapeutic responses in patients with PAH. Although far from reaching its future potential, these techniques have not only provided global RV assessment but also allowed evaluation of changes in cellular and molecular tissue processes, such as metabolism, oxygen balance and ischemia, angiogenesis, and apoptosis. Integrated application of these techniques could provide full insights into the different pathophysiological aspects of a failing RV in the setting of PAH. Recent advances in hybrid imaging have implemented simultaneous measurements of myocardial and vascular interactions and will be one of the most important potential future developments.

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Feasibility and Accuracy of Different Techniques of Two-Dimensional Speckle Based Strain and Validation With Harmonic Phase Magnetic Resonance Imaging

Cited by 174 publications

References 24 publications

Myocardial strain assessment by cine cardiac magnetic resonance imaging using non-rigid registration

Myocardial strain assessment by cine cardiac magnetic resonance imaging using non-rigid registration

Discrepancy between regional left ventricular regional circumferential strain assessed by MR-tagging and by speckle tracking echocardiography

State of the Art: Advanced Imaging of the Right Ventricle and Pulmonary Circulation in Humans (2013 Grover Conference Series)

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