Feasibility and acceptability of home-based strength training in endometrial cancer survivors

Gorzelitz, Jessica; Costanzo, Erin S.; Gangnon, Ronald E.; Koltyn, Kelli F.; Dietz, Amy Trentham; Spencer, Ryan; Rash, J. Keogh; Cadmus-Bertram, Lisa

doi:10.1007/s11764-021-00990-3

Cited by 4 publications

(3 citation statements)

References 39 publications

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“…Briefly, adherence to the exercise prescription was high with 75% of the intervention group completing at least two sessions per week. On average, participants reported 19.2 sessions over the 10-week period out of the expected 20 sessions total [22].…”

Section: Intervention Groupmentioning

confidence: 99%

Improvements in strength and agility measures of functional fitness following a telehealth-delivered home-based exercise intervention in endometrial cancer survivors

Gorzelitz

Stoller

Costanzo

et al. 2021

Support Care Cancer

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Purpose Endometrial cancer is strongly linked to obesity and inactivity; however, increased physical activity has important benefits even in the absence of weight loss. Resistance (strength) training can deliver these benefits; yet few women participate in resistance exercise. The purpose of this study was to describe both physiological and functional changes following a home-based strength training intervention. Methods Forty post-treatment endometrial cancer survivors within 5 years of diagnosis were enrolled in a pilot randomized trial, comparing twice-weekly home-based strength exercise to wait list control. Participants conducted the exercises twice per week for 10 supervised weeks with 5 weeks of follow-up. Measures included DXA-measured lean mass, functional fitness assessments, blood biomarkers, and quality of life outcomes. Results On average, participants were 60.9 years old (SD = 8.7) with BMI of 39.9 kg/m 2 (SD = 15.2). At baseline, participants had 51.2% (SD = 6.0) body fat, which was not different between groups. Improvements were seen in the 30-s chair sit to stand (d = .99), the 30-s arm curl (d = .91), and the 8-ft up-and-go test (d = .63). No changes were measured for HbA1c or C-reactive protein. No changes were observed for flexibility (chair sit and reach, back scratch tests), 6-min walk test, maximum handgrip test, anxiety, depression, fatigue, or self-efficacy for exercise. Conclusions Home-based muscle-strengthening exercise led to favorable and clinically relevant improvements in 3 of 7 physical function assessments. Physical function, body composition, blood biomarkers, and patient-reported outcomes were feasible to measure. These fitness improvements were observed over a relatively short time frame of 10 weeks.

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Section: Intervention Groupmentioning

confidence: 99%

Improvements in strength and agility measures of functional fitness following a telehealth-delivered home-based exercise intervention in endometrial cancer survivors

Gorzelitz

Stoller

Costanzo

et al. 2021

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“…Studies by Rossi et al and Koutoukidis et al evaluating face to face interventions delivered through group sessions have reported rates of 60 to 77% [ 31 , 35 ]. Other home-based interventions which evaluated telephone counselling or mobile applications also reported lower adherence rates [ 13 , 15 , 32 , 34 ]. However, the large variation in recruitment strategies, eligibility criteria, program components and duration preclude direct comparisons.…”

Section: Discussionmentioning

confidence: 99%

“…However, addressing this in the endometrial cancer population has proven to be a significant challenge, specifically for older survivors (aged >65 years) [ 11 , 12 ]. Most studies have focused on demonstrating feasibility of home-based or unsupervised interventions but have so far failed to demonstrate the necessary improvements in weight, physical activity and quality of life [ 13 , 14 , 15 , 16 ]. The effect of supervised exercise interventions for women have not been extensively assessed, despite these patients expressing a specific interest in one-to-one exercise sessions within 6 months after treatment [ 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Feasibility and Effectiveness of the Exercise Program in Endometrial Cancer; Feasibility and Acceptability Survivorship Trial (EPEC-FAST)

Smits

Galaal²,

Winnan

et al. 2022

Cancers

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To evaluate the feasibility of an individualized exercise program in the standard care for endometrial cancer patients aimed to improve quality of life and other health outcomes. This was a single-arm prospective intervention trial to assess the feasibility of an individualized exercise intervention in endometrial cancer patients after treatment. The exercise intervention consisted of weekly individualized training sessions, for 10 weeks, at a local gym facility. The program started six weeks post-operatively. Primary outcomes were feasibility aspects including number of eligible patients, recruitment and adherence rates. Secondary outcomes included quality of life outcomes and anthropometric measures. A total of 54 women were eligible for participation, of which 22 (41%) consented to the study. Overall attendance was 86%, and there were no adverse events. There was a significant improvement in quality of life outcomes, including role (p = 0.02), emotional (p = 0.02) and cognitive functioning (p = 0.04). In addition, there was a significant improvement in visceral fat percentage (p = 0.039) and physical fitness (six-minute walk test p < 0.001). The maximum weight loss achieved was 6.0 kg after 3 months and 8.4 kg after 6 months. An individualized one-to-one exercise intervention in endometrial cancer patients is feasible in terms of recruitment, adherence and safety.

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Interventions for weight reduction in obesity to improve survival in women with endometrial cancer

Agnew

Kitson

Crosbie

2023

Cochrane Database of Systematic Reviews

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This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:To determine the impact of weight loss interventions, in addition to standard management of endometrial cancer, on overall survival and the frequency of adverse events. Secondary objectives include an assessment of weight loss interventions on endometrial cancerspecific survival, cardiovascular event frequency, and QoL, stratified according to patient BMI, and patient and tumour characteristics. 1 Interventions for weight reduction in obesity to improve survival in women with endometrial cancer (Protocol)

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Feasibility and acceptability of home-based strength training in endometrial cancer survivors

Cited by 4 publications

References 39 publications

Improvements in strength and agility measures of functional fitness following a telehealth-delivered home-based exercise intervention in endometrial cancer survivors

Improvements in strength and agility measures of functional fitness following a telehealth-delivered home-based exercise intervention in endometrial cancer survivors

Feasibility and Effectiveness of the Exercise Program in Endometrial Cancer; Feasibility and Acceptability Survivorship Trial (EPEC-FAST)

Interventions for weight reduction in obesity to improve survival in women with endometrial cancer

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