Feasibility and acceptability of artemisinin-based combination therapy for the home management of malaria in four African sites

Ajayi, IkeOluwapo O.; Browne, Edmund; Garshong, Bertha; Bateganya, Fred; Yusuf, Bidemi; Agyei‐Baffour, Peter; Doamekpor, Leticia; Balyeku, Andrew; Munguti, Kaendi; Cousens, Simon; Pagnoni, Franco

doi:10.1186/1475-2875-7-6

Cited by 123 publications

(152 citation statements)

References 23 publications

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“…This is in line with many other studies that have shown the acceptability of community case management of disease starting with diarrhea and malaria [51][52][53] and more recent research on iCCM including pneumonia care. 19,20 This is likely because the CHWs in this program have been providing services which are considered valuable to the community.…”

Section: Discussionsupporting

confidence: 75%

Perceived Quality of Care of Community Health Worker and Facility-Based Health Worker Management of Pneumonia in Children Under 5 Years in Western Kenya: A Cross-Sectional Multidimensional Study

Shaw

Asadhi

Owuor

et al. 2016

The American Journal of Tropical Medicine and Hygiene

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Abstract. Integrated community case management (iCCM) programs that train lay community health workers (CHWs) in the diagnosis and treatment of diarrhea, malaria, and pneumonia have been increasingly adopted throughout subSaharan Africa to provide services in areas where accessibility to formal public sector health services is low. One important aspect of successful iCCM programs is the acceptability and utilization of services provided by CHWs. To understand community perceptions of the quality of care in an iCCM intervention in western Kenya, we used the Primary Care Assessment Survey to compare caregiver attitudes about the diagnosis and treatment of childhood pneumonia as provided by CHWs and facility-based health workers (FBHWs). Overall, caregivers rated CHWs more highly than FBHWs across a set of 10 domains that capture multiple dimensions of the care process. Caregivers perceived CHWs to provide higher quality care in terms of accessibility and patient relationship and equal quality care on clinical aspects. These results argue for the continued implementation and scale-up of iCCM programs as an acceptable intervention for increasing access to treatment of childhood pneumonia.

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Section: Discussionsupporting

confidence: 75%

Perceived Quality of Care of Community Health Worker and Facility-Based Health Worker Management of Pneumonia in Children Under 5 Years in Western Kenya: A Cross-Sectional Multidimensional Study

Shaw

Asadhi

Owuor

et al. 2016

The American Journal of Tropical Medicine and Hygiene

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“…This is in line with the findings from a multi-country study which showed high community acceptability of CHWs management of sick children, with most children receiving treatment on the same day or within one day of onset of symptoms [15]. Similarly, Kilian et al [16] in western Uganda, found high acceptability of pre-packaged antimalarial drugs in the hands of CHWs. In the present study, the high community acceptability of RDTs was partly due to the appreciation that CHWs would be able to offer treatment which was based on test results rather than just presence of symptoms and signs.…”

Section: Community Acceptability Of Rapid Diagnostic Test For Malariasupporting

confidence: 76%

Health Care Worker’s Experience on Rapid Diagnostic Test (Rdt) for Malaria and Their Views on Community Acceptability of Rdt in Rubavu District, Rwanda: Qualitative Study

Misbah¹

2017

Malaria Contr Elimination

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Background: Malaria remains one of the major public health problems in Rwanda. The country introduced artemisinin combination therapy (ACT) at community level using community health workers (CHWs) for treatment of uncomplicated malaria in 2008. Use of ACT with reliance on presumptive diagnosis may lead to excessive use, increased costs and rise of drug resistance. Thus to overcome these challenges, rapid diagnostic tests (RDTs) was introduced to be done by CHWs. This study assessed health care workers experience regarding RDT and their feelings on acceptability of RDTs by community members.

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“…Our results were similar to those recently reported for Africa (81% in Uganda, 93% in Nigeria, and 97% in Ghana). 26 As suggested by Pagnoni,13 these data provide some reassurance concerning the likelihood of selecting drug-resistant parasites through exposure to sub-therapeutic levels of drugs. 27 However, the high degree of compliance observed in this study, which was not obtained under real life conditions, strongly suggests that CHWs must be trained in the correct use of antimalarial drugs.…”

Section: Discussionmentioning

confidence: 99%

Compliance, Safety, and Effectiveness of Fixed-Dose Artesunate-Amodiaquine for Presumptive Treatment of Non-Severe Malaria in the Context of Home Management of Malaria in Madagascar

Ratsimbasoa¹,

Ravony²,

Vonimpaisomihanta³

et al. 2012

The American Journal of Tropical Medicine and Hygiene

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Abstract. Home management of malaria is recommended for prompt, effective antimalarial treatment in children less than five years of age. Compliance, safety, and effectiveness of the new fixed-dose artesunate-amodiaquine regimen used to treat suspected malaria were assessed in febrile children enrolled in a 24-month cohort study in two settings in Madagascar. Children with fever were asked to visit community health workers. Presumptive antimalarial treatment was given and further visits were scheduled for follow-up. The primary endpoint was the risk of clinical/parasitologic treatment failure. Secondary outcomes included fever/parasite clearance, change in hemoglobin levels, and frequency of adverse events. The global clinical cure rate was 98.4% by day 28 and 97.9% by day 42. Reported compliance was 83.4%. No severe adverse effects were observed. This study provides comprehensive data concerning the clinical cure rate obtained with artesunate-amodiaquine and evidence supporting the scaling up of home management of malaria.

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Feasibility and acceptability of artemisinin-based combination therapy for the home management of malaria in four African sites

Cited by 123 publications

References 23 publications

Perceived Quality of Care of Community Health Worker and Facility-Based Health Worker Management of Pneumonia in Children Under 5 Years in Western Kenya: A Cross-Sectional Multidimensional Study

Perceived Quality of Care of Community Health Worker and Facility-Based Health Worker Management of Pneumonia in Children Under 5 Years in Western Kenya: A Cross-Sectional Multidimensional Study

Health Care Worker’s Experience on Rapid Diagnostic Test (Rdt) for Malaria and Their Views on Community Acceptability of Rdt in Rubavu District, Rwanda: Qualitative Study

Compliance, Safety, and Effectiveness of Fixed-Dose Artesunate-Amodiaquine for Presumptive Treatment of Non-Severe Malaria in the Context of Home Management of Malaria in Madagascar

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