Feasibility and acceptability of a multi-domain intervention to increase Mediterranean diet adherence and physical activity in older UK adults at risk of dementia: protocol for the MedEx-UK randomised controlled trial

Shannon, Oliver M.; Lee, Vivian Y.; Bundy, Rafe; Gillings, Rachel; Jennings, Amy; Stephan, Blossom Christa Maree; Hornberger, Michael; Balanos, George M.; Paddick, Stella Maria; Hanson, Sarah; Hardeman, Wendy; Holmes, Rebecca; Garner, Nikki; Aldred, Sarah; Siervo, Mario; Mathers, John C.; Minihane, Anne‐Marie

doi:10.1136/bmjopen-2020-042823

Cited by 17 publications

(16 citation statements)

References 94 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly, MedEx, is a recently completed RCT which has examined the feasibility of adopting a MDP and a MDP plus PA intervention in UK adults at risk of agerelated cognitive decline. MedEx utilised strategies including self-selected dietary targets, group sessions, digital support and food deliveries to help individuals make and sustain healthy lifestyle choices (34) . The lack of research evidence and potential benefits of a combined MDP and PA was reviewed by Hershey and colleagues (35) .…”

Section: Mdp Adoption Approachesmentioning

confidence: 99%

The health benefits and practical considerations for the adoption of a Mediterranean-style dietary pattern

Minihane

Murphy

2022

Br J Nutr

Self Cite

View full text Add to dashboard Cite

The term Mediterranean diet first appeared in the late 1940s (1) . It is described by UNESCO as 'a set of skills, knowledge, practices and traditions ranging from the landscape to the table, including the crops, harvesting, fishing, conservation, processing, preparation and, particularly, consumption of food'. A Mediterranean dietary pattern (MDP) varies in composition between the 21 countries which make up the Mediterranean region but is typically characterised by high intakes of minimally processed plant-based foods such as fruits, vegetables, nuts, seeds, legumes and wholegrains. Extra virgin olive oil is the main culinary fat, with a moderate intake of dairy products, and a variety of herbs and spices used as condiments, rather than salt. Fish/seafood is typically consumed two-three times per week.Red and processed meat, and discretionary foods including sugar or honey sweetened food and drink are consumed in low amounts. Wine, and in particular red wine, is consumed in moderation and with meals. Although in many ways analogous to other global healthy plantbased dietary patterns, it is the high intakes of olive oil, nuts and red wine, which makes the MDP unique. The MDP has been used as a benchmark for comparison with other dietary

show abstract

Section: Mdp Adoption Approachesmentioning

confidence: 99%

The health benefits and practical considerations for the adoption of a Mediterranean-style dietary pattern

Minihane

Murphy

2022

Br J Nutr

Self Cite

View full text Add to dashboard Cite

show abstract

“…The workshop was delivered as two half‐day virtual events, held on the 28th September 2020 and the 17th February 2021. Prior to the first meeting, the following documents were provided to all registered participants to show the relevant policy and scientific background to the NuLifE remit. A summary of the workshop bid to the MRC Infographic of the UK Eatwell Guide (PHE, 2016a) Public Health England's dietary recommendations for the UK 2016 (PHE, 2016b) Mortality and life expectancy trends in the UK (Marshall et al, 2019) Advancing our Health: Prevention in the 2020s (Department of Health & Social Care, 2019) World Health Organization: Risk reduction of cognitive decline and dementia 2019 (WHO, 2019) Schulze M et al, Food based dietary patterns and chronic disease prevention (Schulze et al, 2018) Scheelbeek P, Dangour A et al, Health impacts and environmental footprints of diets that meet the Eatwell Guide recommendations: analyses of multiple UK studies (Scheelbeek et al, 2020) Slide sets summarising previous nutrition randomised controlled trials ( Nu ‐ AGE , CRESSIDA , PREDIMED , Food4Me , MedEx ) (Berendsen et al, 2018; Celis‐Morales et al, 2017; Estruch et al, 2018; Reidlinger et al, 2015; Shannon et al, 2021) …”

Section: Workhops Structurementioning

confidence: 99%

“…Prior to the first meeting, the following documents were provided to all registered participants to show the relevant policy and scientific background to the NuLifE remit. (Berendsen et al, 2018;Celis-Morales et al, 2017;Estruch et al, 2018;Reidlinger et al, 2015;Shannon et al, 2021) NULIFE WORKSHOP 1…”

Section: Workhops Structurementioning

confidence: 99%

See 1 more Smart Citation

Medical Research Council Hot Topic workshop report: Planning a UK Nutrition and Healthy Life Expectancy Trial

et al. 2021

Self Cite

View full text Add to dashboard Cite

There is a drive in the UK to harness findings from novel fundamental and efficacy nutritional research and, through inter-disciplinary and multi-agency collaborations, to improve eating behaviour for the benefit of population health. This report summarises the progress made during the Medical Research Councilfunded Hot Topic workshop on the planning for a potential UK-wide nutrition primary prevention randomised controlled trial with incident disease as the study endpoint: the UK Nutrition and Healthy Life Expectancy (NuLifE) Trial. Through two workshops, along with online discussions and a systematic evidence synthesis, over 40 experts from a range of disciplines came together over 6 months.The workshop reached a consensus and delivered a three-stage plan with the ultimate ambitious aim of providing effective eating behaviour change strategies to address the growing inequalities in the UK and contribute to both a reduced risk of prevalent diet-related chronic disease and an increase in healthy life expectancy.

show abstract

“…A secondary cross-sectional analysis of baseline data from 91 adults aged 54–74y at recruitment in the MedEx-UK study (6) was performed. MedDiet adherence was defined by the 14-item Mediterranean Diet Adherence Screener (MEDAS) questionnaire, and participants were dichotomised into higher and lower adherence groups at the sample-specific median MEDAS score.…”

mentioning

confidence: 99%

Associations between Mediterranean diet adherence and memory performance in older UK adults at higher cardiovascular disease risk

2023

View full text Add to dashboard Cite

Contrary to major national and international forecasts, life expectancy (LE) in the UK has not reached a plateau but has increased to 81y in 2020 (1) . However, at a ratio of healthy ageing life expectancy to LE at 0.8 (2) , the marked demographic shift has been accompanied by a higher prevalence of chronic diet-related non-communicative diseases (3) , including CVD and dementia (4) . Although substantial evidence from Mediterranean countries has verified the protective role of a traditional Mediterranean Diet (MedDiet) against CVD and age-related cognitive decline, it remains unclear if similar benefits occur in non-Mediterranean populations (5) . This study investigated associations between MedDiet adherence and memory performance in older UK-based adults at higher CVD risk.A secondary cross-sectional analysis of baseline data from 91 adults aged 54-74y at recruitment in the MedEx-UK study (6) was performed. MedDiet adherence was defined by the 14-item Mediterranean Diet Adherence Screener (MEDAS) questionnaire, and participants were dichotomised into higher and lower adherence groups at the sample-specific median MEDAS score. Participant characteristics between MedDiet adherence groups were compared using Chi-squared tests for categorical variables, and either independent sample t-tests or Mann-Whitney U tests for continuous variables, with statistical significance set at 0.05. Memory performance was evaluated using the Rey Auditory-Visual Learning Test (RAVLT) and the visual and verbal paired associates test. Using the MEDAS score both as a continuous and a categorical variable, linear alongside logistic regression models were implemented to examine associations between MedDiet adherence and episodic memory performance.The study sample was predominantly females (79.1%), Caucasian (98.9%) and mean ± SD participant age was 67.1 ± 4.6y. There were no significant differences between higher (MEDAS scores 6-12) vs. lower (MEDAS scores 0-5) MedDiet adherence groups for age, gender, BMI, smoking status, deprivation index, blood pressure, HDL cholesterol, medication use, the multicomponent cardiovascular QRISK2 score, and physical activity (all P > 0.05). In multivariate analyses iteratively adjusted for the same variables, there were no significant associations between MedDiet adherence and most episodic memory test outcomes (P > 0.05). Participants with lower MedDiet adherence were at increased odds of poorer performance in the immediate recall of the RAVLT (fully adjusted model, OR: 2.49; 95% CI: 1.03, 6.01; P = 0.043). However, this association was no longer statistically significant after using the Bonferroni-adjusted threshold for multiple comparisons (α = 0.01). In conclusion, there was no evidence of associations between MedDiet adherence and episodic memory in this cohort of UK-based adults at higher CVD risk. Larger prospective cohort studies and long-term RCTs, ideally targeting middle-aged individuals in prodromal dementia stages, are warranted to clarify associations with episodic memory, and other cognit...

show abstract

Feasibility and acceptability of a multi-domain intervention to increase Mediterranean diet adherence and physical activity in older UK adults at risk of dementia: protocol for the MedEx-UK randomised controlled trial

Cited by 17 publications

References 94 publications

The health benefits and practical considerations for the adoption of a Mediterranean-style dietary pattern

The health benefits and practical considerations for the adoption of a Mediterranean-style dietary pattern

Medical Research Council Hot Topic workshop report: Planning a UK Nutrition and Healthy Life Expectancy Trial

Associations between Mediterranean diet adherence and memory performance in older UK adults at higher cardiovascular disease risk

Contact Info

Product

Resources

About