Fear of hypoglycemia: Influence on glycemic variability and self-management behavior in young adults with type 1 diabetes

Martyn‐Nemeth, Pamela; Quinn, Lauretta; Penckofer, Sue; Park, Chang Gyu; Hofer, V. H.; Burke, Larisa A.

doi:10.1016/j.jdiacomp.2016.12.015

Cited by 101 publications

(108 citation statements)

References 40 publications

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“…However, the percentage of younger individuals with T1D with a weight problem is higher than those without diabetes, indicating the presence of additional mechanisms. For example, repeated hypoglycaemia or even the fear of hypoglycaemia results in maladaptive eating habits that favour the development of obesity . Peripheral insulin resistance precipitated by subcutaneous insulin administration rather than the physiological portal vein delivery, is another additional factor in the development of DD .…”

Section: Pathogenesis Of Ddmentioning

confidence: 99%

Double diabetes: A distinct high‐risk group?

Kietsiriroje

Pearson

Campbell

et al. 2019

Diabetes Obesity Metabolism

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The term double diabetes (DD) has been used to refer to individuals with type 1 diabetes (T1D) who are overweight, have a family history of type 2 diabetes and/or clinical features of insulin resistance. Several pieces of evidence indicate that individuals who display features of DD are at higher risk of developing future diabetes complications, independently of average glucose control, measured as glycated haemoglobin (HbA1c) concentration. Given the increased prevalence of individuals with features of DD, pragmatic criteria are urgently required to identify and stratify this group, which will help with subsequent implementation of more effective personalized interventions. In this review, we discuss the potential criteria for the clinical identification of individuals with DD, highlighting the strengths and weaknesses of each definition. We also cover potential mechanisms of DD and how these contribute to increased risk of diabetes complications. Special emphasis is placed on the role of estimated glucose disposal rate (eGDR) in the diagnosis of DD, which can be easily incorporated into clinical practice and is predictive of adverse clinical outcome. In addition to the identification of individuals with DD, eGDR has potential utility in monitoring response to different interventions. T1D is a more heterogeneous condition than initially envisaged, and those with features of DD represent a subgroup at higher risk of complications. Pragmatic criteria for the diagnosis of individuals with DD will help with risk stratification, allowing a more personalized and targeted management strategy to improve outcome and quality of life in this population.

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Section: Pathogenesis Of Ddmentioning

confidence: 99%

Double diabetes: A distinct high‐risk group?

Kietsiriroje

Pearson

Campbell

et al. 2019

Diabetes Obesity Metabolism

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“…Those with greater FOH have reported more frequent nocturnal hypoglycaemia (Anderbro et al., ) and greater sleep disruption due to waking to monitor blood glucose levels (Tanenbaum & Gonzalez, ). FOH has also been found to be associated with greater GV in a time‐dependent relationship, with FOH preceding heightened GV (Martyn‐Nemeth et al., ).…”

Section: Introductionmentioning

confidence: 99%

Poor sleep quality is associated with nocturnal glycaemic variability and fear of hypoglycaemia in adults with type 1 diabetes

Martyn‐Nemeth

Phillips

Mihăilescu

et al. 2018

Journal of Advanced Nursing

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“…11 Furthermore, other associations have been shown between FoH diabetes-related quality of life and psychological well-being 12 and personality traits such as anxiety. 7,13 FoH is greater at night and may contribute to poor sleep quality.…”

mentioning

confidence: 99%

A longitudinal study of fear of hypoglycaemia in adults with type 1 diabetes

Anderbro

Amsberg

Moberg

et al. 2018

Endocrino Diabet & Metabol

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Summary Aims To investigate fear of hypoglycaemia (FoH) longitudinally in a cross‐sectional study of adult patients with type 1 diabetes. Specifically, we investigated two subgroups of patients who over 4 years either showed a substantial increase or decrease in level of FoH to identify factors associated with changes in FoH. Methods The Swedish version of the Hypoglycaemia Fear Survey (HFS) along with a questionnaire to assess hypoglycaemia history was sent by mail to 764 patients in 2010. The responders in 2010 (n = 469) received another set of the same two questionnaires in 2014. HbA1c, insulin regimen, weight and creatinine from 2010 and 2014 were obtained from medical records. Those with an absolute difference in HFS scores ≥ 75th percentile were included in the subgroup analyses. Statistical analyses included one‐sample t tests, chi‐square and McNemar's test. Results The absolute difference in the HFS total score (n = 347) between 2010 and 2014 was m = ±7.6, SD ± 6. In the increased FoH group, more patients reported a high level of moderate hypoglycaemic episodes as well as impaired awareness of hypoglycaemia in 2014 compared with the decreased FoH group. There were more subjects in the increased FoH group with insulin pumps in 2014 and in 2010. In the decreased FoH group, more patients had a high frequency of daily self‐monitoring of blood glucose (SMBG) in 2010 and in 2014. Conclusions Fear of hypoglycaemia is stable across time for most patients. Changes in fear level are associated with changes in hypoglycaemia frequency. Thus, asking patients about changes in hypoglycaemia experiences is of great importance.

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Fear of hypoglycemia: Influence on glycemic variability and self-management behavior in young adults with type 1 diabetes

Cited by 101 publications

References 40 publications

Double diabetes: A distinct high‐risk group?

Double diabetes: A distinct high‐risk group?

Poor sleep quality is associated with nocturnal glycaemic variability and fear of hypoglycaemia in adults with type 1 diabetes

A longitudinal study of fear of hypoglycaemia in adults with type 1 diabetes

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