Fear extinction rescuing effects of dopamine and L-DOPA in the ventromedial prefrontal cortex
Simone B. Sartori,
Thomas M. V. Keil,
Kai K. Kummer
et al.
Abstract:The ventromedial prefrontal cortex (vmPFC; rodent infralimbic cortex (IL)), is posited to be an important locus of fear extinction-facilitating effects of the dopamine (DA) bio-precursor, L-DOPA, but this hypothesis remains to be formally tested. Here, in a model of impaired fear extinction (the 129S1/SvImJ inbred mouse strain; S1), we monitored extracellular DA dynamics via in vivo microdialysis in IL during fear extinction and following L-DOPA administration. Systemic L-DOPA caused sustained elevation of ext… Show more
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