Fe3O4@SiO2 magnetic nanoparticles for bulk scale synthesis of 4′-chloro-2,2′:6′,2″-terpyridine

Chandrappa, M.; Reddy, G. Venkateswar; Rahaman, Fazlur; Murthy, B. Narasimha; Pullela, Phani Kumar; Kumar, Sunil

doi:10.1007/s11696-017-0238-0

Cited by 5 publications

(2 citation statements)

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“…The Fe 3 O 4 @SiO 2 is present in the reaction throughout till the product isolation and hence is part of catalysis of both condensation and cyclisation. Our previous publications in this domain have proved that Fe 3 O 4 @SiO 2 can aid in both condensation and cyclisation [19] , [20] . The proof for the reduction of reaction time and yield improvement with nanocatalyst is shown in Fig.…”

Section: Resultsmentioning

confidence: 93%

Nanomaterial assisted bulk scale synthesis of 2-methyl-6-nitroquinoline

Chandrappa

R²,

Kumar³

et al. 2021

Materials Today: Proceedings

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Quinolines are an interesting class of moieties with various medicinal chemistry uses. The most prominent is their ability to be used as the last line of therapy for bacterial and viral infections including recent COVID-19. The synthesis of quinoline is through a cyclization reaction and overall reaction yields are about 20%. The bulky ring and the associated crowding of functional groups limit the catalyst options. In this publication, the use of Fe 3 O 4 @SiO 2 for enhancing yield improvements, especially for heterocyclics is reported. The use of the 40 nm sized silica functionalized magnetite nanoparticles seems to help in both condensation and cyclization steps of representative 2-methyl-6-nitroquinoline. Reaction time reduction due to surface enabled catalysis of nanoparticles is 110 min to 80 min. The reaction yield has doubled due to the presence of catalyst and the mechanism suggests this drastic result is due to stabilization of unstable intermediate on the acidic surface of the silica coating. This near homogeneous catalysis of 40 nm sized, silica functionalized, magnetite nanoparticles have far reaching applications in bulk drug industry for drugs like chloroquine & hydroxychloroquine, the two essential drugs for prophylactic use for COVID-1.

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Section: Resultsmentioning

confidence: 93%

Nanomaterial assisted bulk scale synthesis of 2-methyl-6-nitroquinoline

Chandrappa

R²,

Kumar³

et al. 2021

Materials Today: Proceedings

Self Cite

View full text Add to dashboard Cite

show abstract

“…[11][12][13][14] In recent decades, iron oxide magnetic nanoparticles (Fe 3 O 4 ) have attracted interest due to their chemical resistance, superparamagnetic features, high level contact, cost-effectiveness, and environmental friendliness. [15][16][17][18] Because of the special features of these magnetic nanoparticles, they can be used in different elds such as magnetic resonance imaging (MRI), 19 sensing, 20 pharmacology, 21 and catalysis. [22][23][24] Due to these particular characteristics of the iron oxide magnetic nanoparticles, they can be developed as a practical solid support having stability under reaction conditions and easy separation by an external magnet.…”

Section: Introductionmentioning

confidence: 99%