Fe3O4 Nanoparticles coated with homopolymers of glycerol mono(meth)acrylate and their block copolymers

Wan, Shourong; Zheng, Yuee; Liu, Yuanqin; Yan, Husheng; Liu, Keliang

doi:10.1039/b504607f

Cited by 89 publications

(95 citation statements)

References 45 publications

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“…6 The most commonly used protocol involves coprecipitation of ferrous and ferric ions in basic solutions. [7][8][9][10][11][12] However, the nanoparticles during the process of coprecipitation are likely to aggregate. Consequently, how to prevent aggregation between the nanoparticles during synthesis of Fe 3 O 4 has received considerable attention because the actual applications need welldispersed magnetic nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

Preparation of poly (ethylene oxide)‐graft‐poly (acrylic acid) copolymer stabilized iron oxide nanoparticles via an in situ templated process

Huang

2008

J of Applied Polymer Sci

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Superparamagnetic iron oxide nanoparticles were prepared in the presence of poly (ethylene oxide)-graft-poly (acrylic acid) copolymers via an in situ templated coprecipitation process. The resulted composite nanoparticles consisted of clusters of iron oxide monocrystals embedded inside the polymer chains, and were highly dispersible in aqueous solution. In these graft copolymers, the PAA segments were chemisorbed onto the Fe 3 O 4 nanoparticle surface through their carboxylic acid groups by forming carboxylate groups with the Fe atoms, while PEO segments as the stabilizers extended into the water matrix.Thus the composite nanoparticles exhibited narrow size distribution by the dynamic light scattering measurement. X-ray diffraction and magnetometer data confirmed the crystalline structure and superparamagnetic property of the particles. This procedure provided a good choice for preparing stable iron oxide magnetic nanoparticles with PEO modified surfaces.

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Section: Introductionmentioning

confidence: 99%

Preparation of poly (ethylene oxide)‐graft‐poly (acrylic acid) copolymer stabilized iron oxide nanoparticles via an in situ templated process

Huang

2008

J of Applied Polymer Sci

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“…However, some of these either are not sufficiently bioeliminable or degrade to acidic products often yielding to local inflammation. Therefore, new cost-effective polymers provided with excellent biocompatibility and versatility should be synthesized and studied in view of clinical applications [20], [21] and [22]. In this study we propose inulin-based copolymer as coating agent for SPIONs.…”

Section: Introductionmentioning

confidence: 99%

Inulin-based polymer coated SPIONs as potential drug delivery systems for targeted cancer therapy

Scialabba

Licciardi

Mauro

et al. 2014

European Journal of Pharmaceutics and Biopharmaceutics

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This paper deal with the synthesis and characterization of PEGylated squalene-grafted-inulin amphiphile capable of self-assembling and self-organizing into nanocarriers once placed in aqueous media. It was exploited as coating agent for obtaining doxorubicin loaded superparamagnetic iron oxide nanoparticles (SPIONs) endowed with stealth like behavior and excellent physicochemical stability. Inulin was firstly modified in the side chain with primary amine groups, followed in turn by conjugation with squalenoyl derivatives through common amidic coupling agents and PEGylation by imine linkage. Polymer coated SPIONs were so obtained by spontaneous self-assembling of inulin copolymer onto magnetite surface involving hydrophobic-hydrophobic interactions between the metallic core and the squalene moieties. The system was characterized in terms of hydrodynamic radius, zeta potential, shape and drug loading capacity. On the whole, the stealth-like shell stabilized the suspension in aqueous media, though allowing the release of the doxorubicin loaded in therapeutic range. The cytotoxicity profile on cancer (HCT116) cell line and in vitro drug uptake were evaluated both with and without an external magnetic field used as targeting agent and uptake promoter, displaying that magnetic targeting implies advantageous therapeutic effects, that is amplified drug uptake and increased anticancer activity throughout the tumor mass.

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“…As shown in Fig. 1, the proposed mechanism of stabilization was the multidentate interactions of 1,2-diols on the polymer chain with iron atoms at the surface of the iron oxide nanoparticles (Wan et al, 2005). This process was a good choice for the preparation of stable magnetic fluids with tailored surfaces; PGA or PGMA binds very tightly to the iron oxide surface, is highly hydrophilic, and does not introduce charges on the surface.…”

Section: Polymer Coatingsmentioning

confidence: 99%

“…These formulations of dextran-coated iron oxide nanoparticles have been evaluated extensively for a variety of MRI applications (Josephson et al, 1999). In addition to the traditional polymer coatings, a new kind of biocompatible polymer material has been reported by Wan et al (2005): namely, homopolymers of glycerol monoacrylate or glycerol monomethacrylate, or their block copolymers. Highly stable aqueous magnetic fluids were prepared by coating Fe 3 O 4 nanoparticles with poly(glycerol monoacrylate) (PGA), poly(glycerol monomethacrylate) (PGMA), or diblock copolymers with PGA or PGMA segments.…”

Section: Polymer Coatingsmentioning

confidence: 99%

“…Mechanisms of preventing opsonization by PEG include the shielding of the surface charges, increased surface hydrophilicity (Gabizon & Papahadjopoulos, 1992), and enhanced repulsive interaction between polymer-coated nanoparticles and blood components (Needham et al, 1992). Various methods have been utilized to attach PEG to the MNP surface, including silane grafting to the oxide surface (Butterworth et al, 2001), alkaline coprecipitation of ferric and ferrous ions in the presence of PEG-containing block copolymers (Wan et al, 2005), direct attachment of PEG-containing block copolymers (Guo et al, 2010), polymerization at the MNP surface (Flesch et al, 2005), and modification through sol-gel approaches (Y. Lu et al, 2002).…”

Section: Polymer Coatingsmentioning

confidence: 99%

See 1 more Smart Citation

Multifunctional Magnetic Hybrid Nanoparticles as a Nanomedical Platform for Cancer-Targeted Imaging and Therapy

Yan¹,

Guo²,

Liu³

2012

Biomedical Science, Engineering and Technology

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Fe3O4 Nanoparticles coated with homopolymers of glycerol mono(meth)acrylate and their block copolymers

Cited by 89 publications

References 45 publications

Preparation of poly (ethylene oxide)‐graft‐poly (acrylic acid) copolymer stabilized iron oxide nanoparticles via an in situ templated process

Preparation of poly (ethylene oxide)‐graft‐poly (acrylic acid) copolymer stabilized iron oxide nanoparticles via an in situ templated process

Inulin-based polymer coated SPIONs as potential drug delivery systems for targeted cancer therapy

Multifunctional Magnetic Hybrid Nanoparticles as a Nanomedical Platform for Cancer-Targeted Imaging and Therapy

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