Fe3o4 nanoparticles: A highly efficient and easily reusable catalyst for the one-pot synthesis of xanthene derivatives under solvent-free conditions

Abstract

Magnetically separable Fe3O4 nanoparticles supply environmentally friendly procedure for the synthesis of 14-aryl-14H-dibenzo[a,j]xanthene and 1,8-dioxo-octahydro-xanthene derivatives. These compounds were obtained in high yields and short reaction times by the reaction of dimedone and 2-naphthol with various aromatic aldehydes under solvent-free conditions. The catalyst coluld be easily recovered using an external magnet and reused for six cycles with almost consistent activity

Synthesis and Characterization of Fe3O4@SiO2 NPs as an Effective Catalyst for the Synthesis of Tetrahydrobenzo[a]xanthen-11-ones

“…Three-component condensation of aldehydes, 2-naphthol and cyclic 1, 3- 45 In the context of our interest on sustainable approaches in the preparation of heterocyclic compounds and in continuation of our interest towards the advancement of effective and environmentally friendly nanocatalysts in organic synthesis, [46][47][48][49][50][51][52] we now wish to report a green and efficient method for the preparation of 12-aryl-8,9,10,12-tetrahydrobenzo[a]xanthen-11-ones by MCRs using Fe 3 O 4 @SiO 2 core-shell nanoparticles as robust, environmentally benign and resuabale catalyst with acidic properties.…”

Recent developments on nano-ZnO catalyzed synthesis of bioactive heterocycles

“…In 1893, Biginelli [78] first reported the synthesis of dihydropyrimidinones (26) with only 20-50% yields. In 2015, Hassanpour et al [79] successfully employed ZnO nanoparticles as an efficient catalyst for the synthesis of dihydropyrimidinones (26) in good yields via a one-pot three component reaction between various aldehydes (5), alkyl acetoacetate (17a/17b) and urea (25) or thiourea (25a) in water at 50 °C. ZnO nanoparicles was found to be much more efficient than the commercial ZnO (Scheme 4).…”

“…in nano form, have drawn considerable attention as efficient, environmentally sustainable, heterogeneous catalysts and have found immense applications in various organic transformations that include C-H funtionalizaion [20], synthesis of 2-aminobenzimidazoles, Fig. 1 Some of the marketed drugs containing heterocycles 2-aminobenzothiazoles, benzoxazoles [21], tetrahydrobenzofurans [22], α-aminophosphonate [23], bis-2,3-dihydroquinazolin-4(1H)-ones [24], 1,4-substituted 1,2,3-triazoles [25], xanthenes [26], pyrano [2,3-d]pyrimidines, 4H-chromenes, and dihydropyrano [3,2-c]chromenes [27], substituted pyridines [28], quinoxalin-2-amine [29] and many more [30,31].…”

Ultrasound-assisted one-pot multi-component synthesis of 2-pyrrolidinon-3-olates catalyzed by Co3O4@SiO2core–shell nanocomposite

“…In continuation to improve the synthetic approach for the production of various medicinally active compounds using reusable nanocatalysts and ultrasonic irradiation (22)(23)(24)(25)(26), herein we combined the advantages of ultrasonic irradiation and nanotechnology to design a new and efficient method for synthesis of 2-pyrrolidinon-3-olate derivatives using Co 3 O 4 @SiO 2 nanocomposites as an efficient and reusable heterogeneous catalyst under ultrasonic irradiation (Scheme 1).…”