Abstract:In this work, we present the coating regulations of Fe3O4 nanoparticles (NPs) by the reverse microemulsion
method
to obtain the Fe3O4@SiO2 core/shell
NPs. The regulation produces the core/shell NPs with a single core
and with different shell thicknesses, and it especially can be applied
to different sizes Fe3O4 NPs and avoid the formation
of core-free silica particles. Our results reveal that the silica
coating parameters suitable for Fe3O4 NPs with
certain size are not definitely applicable to that with other… Show more
“…The saturation magnetization value, extracted from the corresponding Reverse Microemulsion method > 16 h [8] General method > 16 h [9] Reverse Microemulsion method 48 h [7] Sol-gel method 6-48 h [1] Microemulsion method 24 h [6] Microemulsion method 20 h [5] Modified Sol-gel method (Our method) 4 h - hysteresis loop, for the uncoated magnetite sample at 300 K is 80 emu/g, and it decreased for the coated samples as expected to be 50.7, 46.1, 43.8, and 42 emu/g, respectively with increasing the thickness of silica shell. The decrement in magnetization value after coating with silica in all the samples may be attributed to the incorporation of nonmagnetic silica shell around the core magnetite nanocubes.…”
Section: Resultsmentioning
confidence: 99%
“…However, these methods are complicated and require long time for the coating of silica. [5][6][7][8]. And, Shiva et al have used the so-called general method for coating of silica to the iron oxide nanoparticles within 16 h [9].…”
“…The saturation magnetization value, extracted from the corresponding Reverse Microemulsion method > 16 h [8] General method > 16 h [9] Reverse Microemulsion method 48 h [7] Sol-gel method 6-48 h [1] Microemulsion method 24 h [6] Microemulsion method 20 h [5] Modified Sol-gel method (Our method) 4 h - hysteresis loop, for the uncoated magnetite sample at 300 K is 80 emu/g, and it decreased for the coated samples as expected to be 50.7, 46.1, 43.8, and 42 emu/g, respectively with increasing the thickness of silica shell. The decrement in magnetization value after coating with silica in all the samples may be attributed to the incorporation of nonmagnetic silica shell around the core magnetite nanocubes.…”
Section: Resultsmentioning
confidence: 99%
“…However, these methods are complicated and require long time for the coating of silica. [5][6][7][8]. And, Shiva et al have used the so-called general method for coating of silica to the iron oxide nanoparticles within 16 h [9].…”
“…Single core MNPs which are uniformly coated with silica are resulted through this process. [128] Zhao et al performed a modified reverse microemulsion synthesis to prepare MNPs coated by silica, with average size of 40 nm. TEOS molecules were immediately added to the resultant MNPs and the reaction was continued for 24 h at room temperature.…”
In order to translate nanotechnology into medical practice, magnetic nanoparticles (MNPs) have been presented as a class of non‐invasive nanomaterials for numerous biomedical applications. In particular, MNPs have opened a door for simultaneous diagnosis and brisk treatment of diseases in the form of theranostic agents. This review highlights the recent advances in preparation and utilization of MNPs from the synthesis and functionalization steps to the final design consideration in evading the body immune system for therapeutic and diagnostic applications with addressing the most recent examples of the literature in each section. This study provides a conceptual framework of a wide range of synthetic routes classified mainly as wet chemistry, state‐of‐the‐art microfluidic reactors, and biogenic routes, along with the most popular coating materials to stabilize resultant MNPs. Additionally, key aspects of prolonging the half‐life of MNPs via overcoming the sequential biological barriers are covered through unraveling the biophysical interactions at the bio–nano interface and giving a set of criteria to efficiently modulate MNPs' physicochemical properties. Furthermore, concepts of passive and active targeting for successful cell internalization, by respectively exploiting the unique properties of cancers and novel targeting ligands are described in detail. Finally, this study extensively covers the recent developments in magnetic drug targeting and hyperthermia as therapeutic applications of MNPs. In addition, multi‐modal imaging via fusion of magnetic resonance imaging, and also innovative magnetic particle imaging with other imaging techniques for early diagnosis of diseases are extensively provided.
“…Другим способом решения проблемы агрегативной неустойчивости магнитных частиц и сохранения их магнитных характеристик является покрытие их оболоч-ками из немагнитного материала, в частности, наноча-стицы оксидов железа покрывают оболочкой кремнезема различной толщины [11]. Кремнезем имеет ряд преиму-ществ перед органическими оболочками, например, он менее подвержен биодеградации [12].…”
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