Fe₂V₄O₁₃ Nanoparticles Based Electrochemical Sensor for the Simultaneous Determination of Guanine and Adenine at Nanomolar Concentration

Abstract

A simple strategy has been proposed for the simultaneous quantification of guanine (GU) and adenine (AD) using Fe2V4O13 nanoparticles (Fe2V4O13 NPs) modified carbon paste electrode (Fe2V4O13NPs/CPE) in phosphate buffer solution (PBS). The Fe2V4O13 NPs were prepared by a simple solution combustion method where sucrose was used as a fuel. The electrochemical behavior of GU and AD at the electrochemical interface has been studied by using cyclic voltammetry (CV) and differential pulse stripping voltammetry (DPSV). The results illustrate that the Fe2V4O13 NPs shows enhanced electrocatalytic activity and voltammetric response towards GU and AD. The proposed sensor showed linearity between the concentration 0.5 and 60 μM with limit of detection (LOD) 32 and 37 nM for GU and AD respectively. The sensitivity towards GU and AD were respectively found to be 1.393 and 1.851 μA/μM. Further, the proposed electrochemical sensor has been successfully employed to determine GU and AD contents in milk powder and calf thymus DNA samples.

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