Fe₂O₃@[proline]–CuMgAl–LDH: A magnetic bifunctional copper and organocatalyst system for one‐pot synthesis of quinolines and 2H‐indazoles in green media

Abstract

A novel magnetic core–shell Fe2O3@[proline]–CuMgAl–L(ayered)D(ouble)H(ydroxide) was designed as an efficient bifunctional catalytic system. To this end, Cu (II) was combined with Mg and Al in the LDH structure and l‐proline was intercalated between LDH layers in order to perform a straightforward synthesis of quinolines and 2H‐indazoles as two important pharmaceutical N‐aryl‐substituted heterocyclic compounds. In this regard, a facile method was employed through consecutive condensation under a mild conditions in choline azide media, which played the role of a reagent and a solvent to avoid toxic solvents and hazardous azidation reagents. These techniques provided considerable improvement in terms of using green media, reducing starting materials, reaching higher yields and offering a shorter reaction time and lower temperature. In conclusion, it was found that the catalyst could be reused five times with no significant loss of activity.

Synthesis of a new 1,2,3-triazoles scaffold using a heterogeneous multifunctional copper photocatalyst for in vitro investigation via click reaction

“…1). 42 Throughout the development process, the catalysts underwent comprehensive characterization utilizing FT-IR, TGA, FE-SEM, MAP, EDS, TEM, ICP, VSM, XRD, DRS, PL, CV, EIS, BET, Mott–Schottky plot, XPS, and various measurements.…”

Palladium supported on MRGO@CoAl‐LDH catalyzed reductive carbonylation of nitroarenes and carbonylative Suzuki coupling reactions using formic acid as liquid CO and H2 source

“…In the recent decades, heterogeneous catalyses have been utilized as the main part of various organic transformations that offer the advantage of easy recovery, reusability, and air stability. [40,41] Layer double hydroxides (LDHs) as a two-dimensional porous structure have been widely employed in heterogeneous catalysts [42] for various reactions including organic transformations. They are known as environmentally friendly structures and show interesting physical and chemical properties.…”