Fe-porphyrin: A redox-related biosensor of hydrogen molecule

Jin, Zhaokui; Zhao, Penghe; Gong, Wangting; Ding, Wenjiang; He, Qianjun

doi:10.1007/s12274-022-4860-y

Cited by 54 publications

(46 citation statements)

References 16 publications

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“…Besides, 3% H 2 treatment significantly stimulated the activities of SOD, POD, CAT, and APX in chives during cold storage [ 17 ]. A recent study proposed that Fe-porphyrin might be a redox-related biosensor of hydrogen molecule for scavenging of ROS [ 31 ]. Porphyrin ring is the active center of CAT, POD and APX [ 32 , 33 , 34 ].…”

Section: Resultsmentioning

confidence: 99%

Molecular Hydrogen Improves Rice Storage Quality via Alleviating Lipid Deterioration and Maintaining Nutritional Values

Cai

Zhao

Zhang

et al. 2022

Plants

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Improvement of the storage quality of rice is a critical challenge for the scientific community. This study assesses the effects of the irrigation with hydrogen nanobubble water (HNW) on the storage quality of rice (Oryza sativa ‘Huruan1212’). Compared with ditch water control, after one year of storage at 25 °C and 70% RH, the HNW-irrigated rice had higher contents of essential amino acids, especially lysine. Importantly, the generation of off-flavors in the stored rice was significantly decreased, which was confirmed by the lower levels of volatile substances, including pentanal, hexanal, heptanal, octanal, 1-octen-3-ol, and 2-heptanone. The subsequent results showed that the HNW-irrigated rice not only retained lower levels of free fatty acid values, but also had increased antioxidant capacity and decreased lipoxygenase activity and transcripts, thus resulting in decreased lipid peroxidation. This study opens a new window for the practical application of HNW irrigation in the production and subsequent storage of crops.

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Section: Resultsmentioning

confidence: 99%

Molecular Hydrogen Improves Rice Storage Quality via Alleviating Lipid Deterioration and Maintaining Nutritional Values

Cai

Zhao

Zhang

et al. 2022

Plants

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“…As the molecular mechanism by which H 2 exerts multiple functions, a target molecule of H 2 was recently identified [ 34 ]. An oxidized form of porphyrin catalyzes the reaction of H 2 with hydroxyl radicals, the most oxidative free radicals, to reduce the oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Inhalation of Hydrogen Gas for Alzheimer’s Disease Patients and Subsequent Long-Term Follow-Up as a Disease-Modifying Treatment: An Open Label Pilot Study

Ono¹,

Nishijima²,

Ohta

2023

Pharmaceuticals

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(1) Background: Alzheimer’s disease (AD) is a progressive and fatal neurodegenerative disorder. Hydrogen gas (H2) is a therapeutic medical gas with multiple functions such as anti-oxidant, anti-inflammation, anti-cell death, and the stimulation of energy metabolism. To develop a disease-modifying treatment for AD through multifactorial mechanisms, an open label pilot study on H2 treatment was conducted. (2) Methods: Eight patients with AD inhaled 3% H2 gas for one hour twice daily for 6 months and then followed for 1 year without inhaling H2 gas. The patients were clinically assessed using the Alzheimer’s Disease Assessment Scale-cognitive subscale (ADAS-cog). To objectively assess the neuron integrity, diffusion tensor imaging (DTI) with advanced magnetic resonance imaging (MRI) was applied to neuron bundles passing through the hippocampus. (3) Results: The mean individual ADAS-cog change showed significant improvement after 6 months of H2 treatment (−4.1) vs. untreated patients (+2.6). As assessed by DTI, H2 treatment significantly improved the integrity of neurons passing through the hippocampus vs. the initial stage. The improvement by ADAS-cog and DTI assessments were maintained during the follow-up after 6 months (significantly) or 1 year (non-significantly). (4) Conclusions: This study suggests that H2 treatment not only relieves temporary symptoms, but also has disease-modifying effects, despite its limitations.

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“…More encouragingly, Jin et al 1 experimentally identified he- matin, a kind of Fe-phorphyrins, as a molecular target/biosensor of H 2 . They found that in both free and protein-confining states, Fe-porphyrin can self-catalyze hydrogenation by reacting with H 2 to obtain high reducibility of Fe-coordinated hydrogen atoms, which subsequently can not only neutralize •OH into H 2 O but also reduce CO 2 into CO in the hypoxic microenvironment.…”

mentioning

confidence: 99%

“…Fe-porphyrin acts as a primary molecular target/biosensor of hydrogen (H 2 ), which can catalyze H 2 to reduce •OH and carbon dioxide (CO 2 ) into H 2 O and carbon monoxide (CO), respectively, for downstream signaling. 1 …”

mentioning

confidence: 99%

“…As envisioned, transition metals-coordinated porphyrin and the molecules with a similar coordination structure are possibly valuable to hydrogen medicine/energy/agriculture for efficient hydrogen storage, safe/precision delivery, customized transformation, and efficient utilization. Jin et al 1 found that hydrogen can enhance the effect of CO, and heme protein has the potential to store and transport hydrogen, which is undoubtedly an important breakthrough in the field of hydrogen biomedicine and puts forward a new direction for future research on the medical mechanism of hydrogen. However, once these effects are identified, there is cause for concern that hydrogen may potentially block oxygen transport and lead to hypoxia in aerobic organisms.…”

mentioning

confidence: 99%

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