Fe (III) ion modulated l-DOPA protected gold nanocluster probe for fluorescence turn on sensing of ascorbic acid

Devi, J.S. Anjali; Salini, Sasidharan; Anulekshmi, A.H.; Praveen, G; George, Sony

doi:10.1016/j.snb.2017.02.151

Cited by 46 publications

(10 citation statements)

References 45 publications

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“…These new bonds formed results in the migration of the excited electrons to the vacant d-orbitals of Fe 3+ , leading to non-radiative recombination of the excitons (e–h), and thus result in PL quenching 6 , 66 – 69 . Additionally, the ferromagnetic structure of Fe 3+ ion may also be a key factor causing splitting discrete energy levels of N-CDs, thus, forming channels for overlap of energy levels and inter system crossing (ISC) resulting in PL emission reduction 70 .…”

Section: Resultsmentioning

confidence: 99%

Fluorescent recognition of Fe3+ in acidic environment by enhanced-quantum yield N-doped carbon dots: optimization of variables using central composite design

Issa

Abidin

Sobri

et al. 2020

Sci Rep

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A versatile synthetic approach for development of highly fluorescent nitrogen-doped carbon dots (n-cDs) from carboxymethylcellulose in the presence of linear polyethyleneimine (Lpei) has been developed. According to single factor method, central composite design incorporated with response surface methodology matrix was applied to find and model optimal conditions for the temperature (220-260 °C), duration (1-3 h) and LPEI weight (0.5-1.5%). The statistical results show that duration was the most significant parameter for efficient carbonization conversion rate in comparison with temperature and Lpei weight. the reduced cubic model (R 2 = 0.9993) shows a good correlation between the experimental data and predicted values. the optimal variables were temperature of 260 °C, duration of 2 h and LPEI weight of 1%. Under these conditions, quantum yield of up to 44% was obtained. The numerically optimized N-CDs have an average size of 3.4 nm with graphitic nature owing to the abundant amino species incorporated into the carbon core framework. the blue-green n-cDs possess emission dependent upon the solvent polarity, wide pH stability with enhanced emission in an acidic environment. Impressively, the N-CDs show long-shelf-life for up to 1 year with no noticeable precipitation. the n-cDs were able to recognize a high concentration of fe 3+ ions with a detection limit of 0.14 μM in acidic solution owing to the special coordination for Fe 3+ to be captured by electron-donating oxygen/ amino groups around n-cDs. Moreover, the n-cDs can also be used as a new kind of fluorescent ink for imaging applications. Carbon dots (CDs) are the latest member of fluorescent carbon nano-sized family. Typically, CDs are nearly spherical-shaped nanoclusters with sizes of less than 10 nm and consist of amorphous or crystalline cores with sp 2 carbon atoms 1. Since the first established work 2 , CDs have attracted a considerable focusing in the fields of wastewater treatment, photocatalysis, bioimaging, cancer therapy and chemical sensing 3,4. This is owing to their feature of having outstanding optical properties, including excellent biocompatibility, tuneable photoluminescence, negligible toxicity, ease of production and resistance to photobleaching in comparison to QDs counterparts 5-7. It is well known that QDs, for instance, tend to be decayed in the biological environment leading to a serious toxicity concern 8 .

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Section: Resultsmentioning

confidence: 99%

Fluorescent recognition of Fe3+ in acidic environment by enhanced-quantum yield N-doped carbon dots: optimization of variables using central composite design

Issa

Abidin

Sobri

et al. 2020

Sci Rep

View full text Add to dashboard Cite

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“…With in signal-off strategies, the target analyte absorption spectra should overlap with the emission spectra of the luminophore, and in signal-on protocols, target analyte should induce the emission of the luminophore. 61,62 In the case of chemical compounds analysis, the target molecule (like a small molecule) acts as an energy donor, while fluorophore is an energy acceptor just opposite to signal-off methods. AuNCs with bright emission have been utilized for recognition of several molecules based on the turnon strategy such as O 2, 63 proteins, 64 neurotransmitters, 65 and enzyme substrates.…”

Section: Fundamental Aspects Of Ncsmentioning

confidence: 99%

Metal Nanoclusters in Point-of-Care Sensing and Biosensing Applications

Nasrollahpour

Jurado‐Sánchez

Moradi

2023

ACS Appl. Nano Mater.

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Nanoclusters are nanostructures consisting of few to tens of atoms which have attracted great interest from the scientific community due to their applications in a myriad of fields, from catalysis to biomedical applications. Due to the discrete energy levels resulting from their ultrasmall size, nanoclusters exhibit distinctly different chemical, optical, and electrical properties compared with their larger nanoparticle counterparts. Unlike previously reported nanostructures with larger dimensions (1–10 nm), which typically have a single advantage (for example, high conductivity or optical properties), nanoclusters can be used as signaling and/or reaction-accelerating materials in almost all sensing assays with enhanced properties. Nanoclusters are among the most promising luminescent emitters (electrochemiluminescent, fluorescent, chemiluminescent, and colorimetry) with high quantum yield and better biocompatibility than conventional emitters. Considering their excelent biocompatibility, tailored modification, and desirable electrochemical and optical tunability, nanoclusters have opened new horizons in designing high-performance sensing and biosensing devices. In addition, they represent excellent electrochemical and photoelectrochemical behaviors with improved functionality and environmentally friendly properties compared to traditional compounds. This review discusses the recent advances in nanoclusters, their applications in sensing and biosensing, current limitations, and prospects to overcome these challenges. The present study gives a much brighter vision of nanoclusters that discusses one by one their particular advantages and role in developing sensing frameworks.

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“…Reproduced with permission. [ 195 ] Copyright 2017, Elsevier. D) Concentration dependent 0–1 µm fluorescence intensity changes of probe 129 in PBS solution (ex: 357 nm, inset: the linear relationship between probe 129 and TTR concentrations).…”

Section: Alzheimer's Diseasementioning

confidence: 99%

“…A recovery percentage of 97–100% has been observed in human serum samples using this sensor, suggesting its potential use in future diagnosis. [ 195 ]…”

Section: Alzheimer's Diseasementioning

confidence: 99%

Fluorescent Diagnostic Probes in Neurodegenerative Diseases

et al. 2020

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Both chronic and acute neurodegenerative diseases have been associated with high morbidity and mortality, along with the death of neurons in different areas of the brain, and there are few or no effective curative therapy options for treatment of patients. [3,4] These disorders are a major cause of concern for the health and quality of life in the aging society, since age is the greatest risk factor for neurodegenerative disease. [5] The World Health Organization has predicted that in next 20 years neurodegenerative disease will become the second most common cause of mortality after cardiovascular disease. [6] Neurodegenerative processes begin long before their clinical symptoms are evident, and evolve for years slowly and irreversibly. Hence, there is an urgent need to diagnose neurodegenerative disease as early as possible and to distinguish between different neurodegenerative disorders with shared and unique symptoms to facilitate decision making regarding choice of treatment. Timely diagnosis is important for the adoption of therapeutic modalities in clinical trials prior to moderate dementia exhibition, to appraise and apply antidotes to maximally preserve the cognitive functions or to slow down the course of these disorders. The ability to analyze and identify risk factors for cognitive deficit would represent an extraordinary advancement in the field of dementia. [5] The main modern diagnostic technologies for the early examination of neurodegenerative disease pathology, neuroimaging techniques, include radioligandsbased positron emission tomography (PET), 3D single-photon emission-computed tomography (SPECT), and structural magnetic resonance imaging (MRI). Although PET and SPECT are the most used imaging techniques for neurodegenerative diseases, their application is limited by high cost, involvement of hazardous radiolabeled compounds, need for sophisticated instruments, and application of complex data acquisition and analysis protocols. The MRI technique has relatively low spatial resolution as well as intrinsically poor sensitivity to distinguish morphological differences between disease biomarkers and the surrounding tissue. Recently, fluorescence diagnosis technology has become an attractive and potential alternative to diagnose and probe the progression of neurodegenerative diseases, because of being rapid, noninvasive, sensitive, simple, real-time, low-cost, and high-resolution in nature. [7] There are several uses for Neurodegenerative diseases are debilitating disorders that feature progressive and selective loss of function or structure of anatomically or physiologically associated neuronal systems. Both chronic and acute neurodegenerative diseases are associated with high morbidity and mortality along with the death of neurons in different areas of the brain; moreover, there are few or no effective curative therapy options for treating these disorders. There is an urgent need to diagnose neurodegenerative disease as early as possible, and to distinguish between different disorders with overlap...

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Fe (III) ion modulated l-DOPA protected gold nanocluster probe for fluorescence turn on sensing of ascorbic acid

Cited by 46 publications

References 45 publications

Fluorescent recognition of Fe3+ in acidic environment by enhanced-quantum yield N-doped carbon dots: optimization of variables using central composite design

Fluorescent recognition of Fe3+ in acidic environment by enhanced-quantum yield N-doped carbon dots: optimization of variables using central composite design

Metal Nanoclusters in Point-of-Care Sensing and Biosensing Applications

Fluorescent Diagnostic Probes in Neurodegenerative Diseases

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