2022
DOI: 10.1002/slct.202103880
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Fe(III)‐Based Layered Double Hydroxides Carrying Model Naproxenate Anions: Compositional and Structural Aspects

Abstract: In this work, Al cation was gradually replaced by FeIII in the composition of Layered Double Hydroxides (LDH) and systematically investigated for LDH application as drug carriers, ultimate aiming to improve their biointegration. The incorporation of FeIII into LDH layers, as well the intercalation of organic anions in the iron‐based materials, is challenging. Several studies approach the intercalation of non‐steroidal anti‐inflammatory drugs such as anionic naproxen (NAP) into Al‐LDH. Thus, NAP was applied her… Show more

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Cited by 5 publications
(3 citation statements)
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“…However, the size/area of the anion can preclude the total neutralization of positively charged layers because of steric hindrance, decreasing the LC, as observed for LDH-pravastatin material [ 146 ]. The intercalation method (coprecipitation or ion exchange, for instance) can also influence drug loading, as noticed in studies with naproxen [ 147 ]. Another kind of interaction can be established beyond the electrostatic one between positively and negatively charged species, as reported when using ultrathin LDH particles in the presence of doxorubicin; for example, LC was 344.56% [ 126 ].…”
Section: Layered Double Hydroxides: Structure Physicochemical Propert...mentioning
confidence: 99%
“…However, the size/area of the anion can preclude the total neutralization of positively charged layers because of steric hindrance, decreasing the LC, as observed for LDH-pravastatin material [ 146 ]. The intercalation method (coprecipitation or ion exchange, for instance) can also influence drug loading, as noticed in studies with naproxen [ 147 ]. Another kind of interaction can be established beyond the electrostatic one between positively and negatively charged species, as reported when using ultrathin LDH particles in the presence of doxorubicin; for example, LC was 344.56% [ 126 ].…”
Section: Layered Double Hydroxides: Structure Physicochemical Propert...mentioning
confidence: 99%
“…Results from literature reported d 00l values varying around 1.60 nm and 1.82 nm for Mg 2 Al-LDH materials synthesized by co-precipitation method at pH 10, in which Fol 3+ is the dominant specie (Figure 1), and R = 2 (Qin et al, 2008;Mallakpour and Hatami, 2019) S3 and Table S1). Therefore, the synthesis method can also influence the arrangement of folate anions inside the interlayer space because the level of ion exchanged anions can be low, generating materials with co-intercalated anions (Figueiredo et al, 2022). In these cases, the organic species (usually bigger than the anions in the precursor LDH) can take a tilted orientation in relation to the layers, decreasing the basal spacing (Figueiredo et al, 2022).…”
Section: Appendix I Supporting Information Materials Of Chapter 2 App...mentioning
confidence: 99%
“…Therefore, the synthesis method can also influence the arrangement of folate anions inside the interlayer space because the level of ion exchanged anions can be low, generating materials with co-intercalated anions (Figueiredo et al, 2022). In these cases, the organic species (usually bigger than the anions in the precursor LDH) can take a tilted orientation in relation to the layers, decreasing the basal spacing (Figueiredo et al, 2022). In fact, higher amount of folate was reported to be intercalated by co-precipitation than by ion- Table S2.…”
Section: Appendix I Supporting Information Materials Of Chapter 2 App...mentioning
confidence: 99%